5.4.2.8: phosphomannomutase

This is an abbreviated version!
For detailed information about phosphomannomutase, go to the full flat file.

Reaction

Synonyms

alpha-D-phosphohexomutase, alpha-phosphomannomutase1, EC 2.7.5.7, IMP-sensitive glucose-1,6-bisphosphatase, ManB, ORF17, PGM/PMM, PGM2, PgmG, phosphoglucomutase/phosphomannomutase, Phosphohexomutase, phosphomannomutase, phosphomannomutase 1, phosphomannomutase 2, phosphomannomutase/phosphoglucomutase, phosphomannomutase2, Phosphomannose mutase, Phosphomutase, mannose, PMM, PMM-1, PMM-2, PMM-A1, PMM-A2, PMM-B1, PMM-B2, PMM-D1, PMM-D2, PMM/PGM, PMM1, PMM2, PMMH-22, SP-2, SSO0207

ECTree

     5 Isomerases

         5.4 Intramolecular transferases

             5.4.2 Phosphotransferases (phosphomutases)

                5.4.2.8 phosphomannomutase

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Results	in table
36	Activating Compound
13631	AA Sequence
5	Application
1	CAS Registry Number
38	Cloned(Commentary)
9	Crystallization (Commentary)
704	Disease/ Diagnostics
1	Expression
12	General Information
2	General Stability
2	IC50 Value
35	Inhibitors
2	kcat/KM [mM/s]
74	KM Value [mM]
5	Localization
26	Metals/Ions
19	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
126	Organism
12	Pathway
58	PDB ID
19	pH Optimum
6	pH Range
1	pH Stability
2	pI Value
4	Posttranslational Modification
67	Protein Variants
29	Purification (Commentary)
6	Reaction
7	Reaction Type
80	Reference
21	Source Tissue
15	Specific Activity [micromol/min/mg]
3	Storage Stability
125	Substrates and Products (Substrate)
19	Subunits
104	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
4	Temperature Range [°C]
6	Temperature Stability [°C]
23	Turnover Number [1/s]

KM Value

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KM Value on EC 5.4.2.8 - phosphomannomutase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

3.5

2-deoxyribose-1-phosphate

Thermococcus kodakarensis

-

90°C

662018

0.006 - 0.4516

alpha-D-glucose 1-phosphate

19 entries

0.0056 - 1.37

alpha-D-mannose 1-phosphate

19 entries

0.0075 - 0.0654

D-glucose 1-phosphate

2 entries

0.0135 - 3

D-glucose-1-phosphate

4 entries

0.018 - 0.15

D-mannose 1-phosphate

4 entries

0.3 - 0.5

D-mannose 6-phosphate

Cassia corymbosa

-

-

3288

0.016 - 3.2

D-mannose-1-phosphate

3 entries

0.0013 - 0.022

glucose 1-phosphate

14 entries

0.003 - 0.2

mannose 1-phosphate

5 entries

0.074

mannose 6-phosphate

Oryctolagus cuniculus

-

in presence of glucose 1,6-diphosphate

3352

additional information

additional information

Pyrococcus horikoshii

-

KM mannose-1-phosphate isoenzyme PH0923S101A not detectable, 37°C

662065

-

0.006

alpha-D-glucose 1-phosphate

Homo sapiens

-

recombinant enzyme PMM1

3359

0.0073

alpha-D-glucose 1-phosphate

Homo sapiens

O15305, Q92871

isoform PMM1, at pH 7.5 and 32°C

749116

0.0082

alpha-D-glucose 1-phosphate

Homo sapiens

O15305, Q92871

isoform PMM2, at pH 7.5 and 32°C

749116

0.012

alpha-D-glucose 1-phosphate

Homo sapiens

-

-

649661

0.0127

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

-

mutant RN110A

680649

0.0132

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

-

mutant R15A

680649

0.0195

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

-

mutant R247A

680649

0.0272

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

P26276

wild type enzyme, at 25°C in 50 mM MOPS (pH 7.4) with 1 mM dithiothreitol, 1.5 mM MgSO4

690999

0.0273

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

-

wild-type

680649

0.0279

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

-

mutant R421C

680649

0.028

alpha-D-glucose 1-phosphate

Acinetobacter haemolyticus

-

at pH 7.5 and 35°C

748602

0.0354

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

P26276

mutant enzyme P368A, at 25°C in 50 mM MOPS (pH 7.4) with 1 mM dithiothreitol, 1.5 mM MgSO4

690999

0.0366

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

P26276

mutant enzyme S369A, at 25°C in 50 mM MOPS (pH 7.4) with 1 mM dithiothreitol, 1.5 mM MgSO4

690999

0.0489

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

P26276

mutant enzyme P368G, at 25°C in 50 mM MOPS (pH 7.4) with 1 mM dithiothreitol, 1.5 mM MgSO4

690999

0.0491

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

P26276

mutant enzyme R262A, at 25°C in 50 mM MOPS (pH 7.4) with 1 mM dithiothreitol, 1.5 mM MgSO4

690999

0.0493

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

P26276

mutant enzyme Y17A, at 25°C in 50 mM MOPS (pH 7.4) with 1 mM dithiothreitol, 1.5 mM MgSO4

690999

0.0518

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

P26276

mutant enzyme E325A, at 25°C in 50 mM MOPS (pH 7.4) with 1 mM dithiothreitol, 1.5 mM MgSO4

690999

0.0667

alpha-D-glucose 1-phosphate

Pseudomonas aeruginosa

P26276

mutant enzyme R262A/P368G, at 25°C in 50 mM MOPS (pH 7.4) with 1 mM dithiothreitol, 1.5 mM MgSO4

690999

0.4516

alpha-D-glucose 1-phosphate

Sphingobium chungbukense

-

in 50 mM Tris-HCl (pH 7.5), at 37°C

692918

0.0056

alpha-D-mannose 1-phosphate

Giardia intestinalis

-

in 50 mM HEPES, pH 7.1, 5 mM MgCl2, at 30°C

715129

0.0065

alpha-D-mannose 1-phosphate

Homo sapiens

O15305, Q92871

isoform PMM1, at pH 7.5 and 32°C

749116

0.017

alpha-D-mannose 1-phosphate

Acinetobacter haemolyticus

-

at pH 7.5 and 35°C

748602

0.0237

alpha-D-mannose 1-phosphate

Homo sapiens

O15305, Q92871

isoform PMM2, at pH 7.5 and 32°C

749116

0.068

alpha-D-mannose 1-phosphate

Arabidopsis thaliana

-

mutant enzyme G7R/R37Q, at 28°C

693211

0.111

alpha-D-mannose 1-phosphate

Arabidopsis thaliana

-

mutant enzyme R37Q, at 28°C

693211

0.1569

alpha-D-mannose 1-phosphate

Sphingobium chungbukense

-

in 50 mM Tris-HCl (pH 7.5), at 37°C

692918

0.2

alpha-D-mannose 1-phosphate

Arabidopsis thaliana

-

wild type enzyme, at 28°C

693211

0.204

alpha-D-mannose 1-phosphate

Arabidopsis thaliana

-

mutant enzyme G7R/R37Q, at 18°C

693211

0.229

alpha-D-mannose 1-phosphate

Arabidopsis thaliana

-

mutant enzyme G7R, at 28°C

693211

0.294

alpha-D-mannose 1-phosphate

Arabidopsis thaliana

-

mutant enzyme R37Q, at 18°C

693211

0.327

alpha-D-mannose 1-phosphate

Trypanosoma brucei

F4NCC2

pH 7.3, 37°C

728329

0.387

alpha-D-mannose 1-phosphate

Arabidopsis thaliana

-

wild type enzyme, at 18°C

693211

0.4

alpha-D-mannose 1-phosphate

Triticum aestivum

C8CK06, C8CK09, C8CK10

isoform PMM-D1, 30°C, pH not specified in the publication

714628

0.46

alpha-D-mannose 1-phosphate

Triticum aestivum

C8CK06, C8CK09, C8CK10

isoform PMM-A1, 37°C, pH not specified in the publication

714628

0.475

alpha-D-mannose 1-phosphate

Arabidopsis thaliana

-

mutant enzyme G7R, at 18°C

693211

0.48

alpha-D-mannose 1-phosphate

Triticum aestivum

C8CK06, C8CK09, C8CK10

isoform PMM-D2, 30°C, pH not specified in the publication

714628

0.68

alpha-D-mannose 1-phosphate

Sphingomonas sanxanigenens

M1T754

recombinant His-tagged enzyme, pH 7.6, temperature not specified in the publication

727228

1.37

alpha-D-mannose 1-phosphate

Zea mays

-

-

649781

0.0075

D-glucose 1-phosphate

Homo sapiens

O15305, Q92871

isoform alpha-PMM1, pH 6.5, 25°C

680647

0.0654

D-glucose 1-phosphate

Arabidopsis thaliana

O80840

30°C, pH 7.5

682378

0.0135

D-glucose-1-phosphate

Homo sapiens

O15305, Q92871

isoform alpha-PMM2, pH 6.5, 25°C

680647

0.0952

D-glucose-1-phosphate

Pyrococcus horikoshii

-

isoenzyme PH0923, 65°C

662065

0.127

D-glucose-1-phosphate

Pyrococcus horikoshii

-

isoenzyme PH0923S101A, 65°C

662065

3

D-glucose-1-phosphate

Thermococcus kodakarensis

-

90°C

662018

0.018

D-mannose 1-phosphate

Homo sapiens

-

-

649661

0.0297

D-mannose 1-phosphate

Arabidopsis thaliana

O80840

30°C, pH 7.5

682378

0.054

D-mannose 1-phosphate

Homo sapiens

O15305, Q92871

isoform alpha-PMM1, pH 6.5, 25°C

680647

0.15

D-mannose 1-phosphate

Cassia corymbosa

-

-

3288

0.016

D-mannose-1-phosphate

Homo sapiens

O15305, Q92871

isoform alpha-PMM2, pH 6.5, 25°C

680647

0.0915

D-mannose-1-phosphate

Pyrococcus horikoshii

-

isoenzyme PH0923, 37°C

662065

3.2

D-mannose-1-phosphate

Thermococcus kodakarensis

-

90°C

662018

0.0013

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

H308N/H329N double mutant

650233

0.0013

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

S108A mutant

650233

0.0024

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

S108A/H308N double mutant

650233

0.0027

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

K118L/H109Q double mutant

650233

0.0028

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

R20A mutant

650233

0.0034

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

S108D mutant

650233

0.008

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

H109Q mutant

650233

0.008

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

K118L mutant

650233

0.009

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

R247A mutant

650233

0.01

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

H308N mutant

650233

0.01

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

S108V mutant

650233

0.012

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

-

650233

0.016

glucose 1-phosphate

Pseudomonas aeruginosa

P26276

H329N mutant

650233

0.022

glucose 1-phosphate

Oryctolagus cuniculus

-

-

3352

0.003

mannose 1-phosphate

Rattus norvegicus

-

-

3359

0.0032

mannose 1-phosphate

Homo sapiens

-

recombinant enzyme PMM1

3359

0.016

mannose 1-phosphate

Oryctolagus cuniculus

-

in presence of glucose 1,6-diphosphate

3352

0.06

mannose 1-phosphate

Pseudomonas aeruginosa

-

-

3353

0.2

mannose 1-phosphate

Amorphophallus konjac

-

-

3350