5.4.2.8: phosphomannomutase
This is an abbreviated version!
For detailed information about phosphomannomutase, go to the full flat file.
Word Map on EC 5.4.2.8
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5.4.2.8
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carbohydrate-deficient
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transferrin
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gdp-mannose
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multisystemic
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cdg-ia
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team
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mannose-1-phosphate
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pectoralis
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phosphoglucomutase
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doctors
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obstetric
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hypoglycosylation
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nipple
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lipid-linked
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psoas
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premammillary
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strabismus
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paromomycin
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meniscectomy
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medicine
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food industry
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biotechnology
- 5.4.2.8
-
carbohydrate-deficient
- transferrin
- gdp-mannose
-
multisystemic
-
cdg-ia
-
team
- mannose-1-phosphate
-
pectoralis
- phosphoglucomutase
-
doctors
-
obstetric
-
hypoglycosylation
-
nipple
-
lipid-linked
-
psoas
-
premammillary
-
strabismus
- paromomycin
-
meniscectomy
- medicine
- food industry
- biotechnology
Reaction
Synonyms
alpha-D-phosphohexomutase, alpha-phosphomannomutase1, EC 2.7.5.7, IMP-sensitive glucose-1,6-bisphosphatase, ManB, ORF17, PGM/PMM, PGM2, PgmG, phosphoglucomutase/phosphomannomutase, Phosphohexomutase, phosphomannomutase, phosphomannomutase 1, phosphomannomutase 2, phosphomannomutase/phosphoglucomutase, phosphomannomutase2, Phosphomannose mutase, Phosphomutase, mannose, PMM, PMM-1, PMM-2, PMM-A1, PMM-A2, PMM-B1, PMM-B2, PMM-D1, PMM-D2, PMM/PGM, PMM1, PMM2, PMMH-22, SP-2, SSO0207
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Inhibitors
Inhibitors on EC 5.4.2.8 - phosphomannomutase
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Disperse Blue 56
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kinetic studies indicate that it is a parabolic, noncompetitive inhibitor. Reduction of the inhibition in the presence of 0.01% Triton X-100
glucose 6-phosphate
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poor, competitive with respect to mannose 6-phosphate
IMP
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IMP stimulates by more than 100fold the intrinsic glucose-1,6-bisphosphatase activity of recombinant PMM1 while inhibiting its phosphoglucomutase activity
inosine monophosphate
inhibits competitively the mutase activity of isoform PMM1
serum- and glucocorticoid-regulated kinase
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Sgk1 decreases the enzymatic activity of PMM2 in the basal state and upon insulin stimulation in intact COS-7 cells
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at high concentrations, competitive with respect to glucose-1,6-diphosphate, Ki: 1.2 mM
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not inhibited by Mg2+, D-glucose 6-phosphate, and EDTA
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additional information
not inhibited by neridronate; not inhibited by neridronate
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additional information
not inhibited by neridronate; not inhibited by neridronate
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additional information
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not inhibited by neridronate; not inhibited by neridronate
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additional information
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not inhibitory: 1,5-diamino-4,8-dihydroxyanthraquinone
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