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5.4.2.8: phosphomannomutase

This is an abbreviated version!
For detailed information about phosphomannomutase, go to the full flat file.

Word Map on EC 5.4.2.8

Reaction

alpha-D-glucose 1-phosphate
=
D-glucose 6-phosphate

Synonyms

alpha-D-phosphohexomutase, alpha-phosphomannomutase1, EC 2.7.5.7, IMP-sensitive glucose-1,6-bisphosphatase, ManB, ORF17, PGM/PMM, PGM2, PgmG, phosphoglucomutase/phosphomannomutase, Phosphohexomutase, phosphomannomutase, phosphomannomutase 1, phosphomannomutase 2, phosphomannomutase/phosphoglucomutase, phosphomannomutase2, Phosphomannose mutase, Phosphomutase, mannose, PMM, PMM-1, PMM-2, PMM-A1, PMM-A2, PMM-B1, PMM-B2, PMM-D1, PMM-D2, PMM/PGM, PMM1, PMM2, PMMH-22, SP-2, SSO0207

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.2 Phosphotransferases (phosphomutases)
                5.4.2.8 phosphomannomutase

Inhibitors

Inhibitors on EC 5.4.2.8 - phosphomannomutase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-deoxyglucose 6-phosphate
-
-
ADP
-
50% inhibition at 5 mM
alpha-D-Glucose 1,6-bisphosphate
-
alpha-D-glucose 1-phosphate
-
ATP
-
20% inhibition at 5 mM
Be2+
-
in histidine buffer
Ca2+
-
50% inhibition at 5 mM
clodronate
specific inhibitor; specific inhibitor
Cu2+
-
in Tris buffer, no inhibition in histidine buffer
D-fructose 6-phosphate
-
38% inhibition at 5 mM
D-Glucose 1,6-bisphosphate
-
90% inhibition at 5 mM
D-xylose 1-phosphate
-
Disperse Blue 56
-
kinetic studies indicate that it is a parabolic, noncompetitive inhibitor. Reduction of the inhibition in the presence of 0.01% Triton X-100
fructose 1-phosphate
-
-
glucose 1-phosphate
-
substrate inhibition of reverse reaction
glucose 6-phosphate
-
poor, competitive with respect to mannose 6-phosphate
IMP
-
IMP stimulates by more than 100fold the intrinsic glucose-1,6-bisphosphatase activity of recombinant PMM1 while inhibiting its phosphoglucomutase activity
inosine monophosphate
inhibits competitively the mutase activity of isoform PMM1
Li+
-
complete inhibition at 5 mM
mannose 1-phosphate
Mn2+
-
complete inhibition above 2 mM
serum- and glucocorticoid-regulated kinase
-
Sgk1 decreases the enzymatic activity of PMM2 in the basal state and upon insulin stimulation in intact COS-7 cells
-
UDP-D-glucose
-
65% inhibition at 5 mM
vanadate
-
0.05 mM, 50% inhibition
additional information
-