5.4.2.3: phosphoacetylglucosamine mutase

This is an abbreviated version!
For detailed information about phosphoacetylglucosamine mutase, go to the full flat file.

Word Map on EC 5.4.2.3

Reaction

N-acetyl-alpha-D-glucosamine 1-phosphate
=
N-acetyl-D-glucosamine 6-phosphate

Synonyms

Acetylglucosamine phosphomutase, Phosphomutase, acetylglucosamine, Acetylaminodeoxyglucose phosphomutase, Phospho-N-acetylglucosamine mutase, PGlcNAc mutase, 2-Acetamido-2-deoxy-D-glucose-1,6-bisphosphate:2-acetamido-2-deoxy-D-glucose 1-phosphate phosphotransferase, EC 2.7.5.2., DNA-damage-repair/toleration protein DRT101, N-acetylglucosamine-phosphate mutase, PAGM, HsAGM1, CaAGM1, AGM1, PGM3, AGM, AGM1/PGM3, phosphoacetylglucosamine mutase 1

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.2 Phosphotransferases (phosphomutases)
                5.4.2.3 phosphoacetylglucosamine mutase

General Information

General Information on EC 5.4.2.3 - phosphoacetylglucosamine mutase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
malfunction
loss-of-function mutations in the nst gene, which encodes PGM3, block fibroblast growth factor signaling during embryonic mesoderm and tracheal development. In nst mutants with an 80% reduction in the amount of UDP-GlcNAc, O-GlcNAcylation is compromised. Embryos maternally and zygotically mutant for nst exhibit defects in mesoderm layer formation during gastrulation that are similar to those observed in embryos with mutations in the gene encoding the fibroblast growth factor receptor Heartless (Htl). Zygotic nst mutants (nstZ) exhibit normal dorsal mesoderm differentiation, embryos homozygous for the hypomorphic htlYY262 allele show a reduction in dorsal mesoderm. Phenotypes, overview. Dof is the critical component in MAPK activation affected in nst mutants
metabolism
Nst acts downstream of fibroblast growth factor receptor signaling
evolution