5.4.2.3: phosphoacetylglucosamine mutase
This is an abbreviated version!
For detailed information about phosphoacetylglucosamine mutase, go to the full flat file.
Word Map on EC 5.4.2.3
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5.4.2.3
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udp-n-acetylglucosamine
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phosphoglucomutase
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pyrophosphorylase
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mutases
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udp-glcnac
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glcnac-6-p
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phosphoglucosamine
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phosphoserine
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synthesis
- 5.4.2.3
- udp-n-acetylglucosamine
- phosphoglucomutase
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pyrophosphorylase
- mutases
- udp-glcnac
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glcnac-6-p
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phosphoglucosamine
- phosphoserine
- synthesis
Reaction
Synonyms
2-Acetamido-2-deoxy-D-glucose-1,6-bisphosphate:2-acetamido-2-deoxy-D-glucose 1-phosphate phosphotransferase, Acetylaminodeoxyglucose phosphomutase, Acetylglucosamine phosphomutase, AGM, AGM1, AGM1/PGM3, CaAGM1, DNA-damage-repair/toleration protein DRT101, EC 2.7.5.2, EC 2.7.5.2., HsAGM1, N-acetylglucosamine-phosphate mutase, PAGM, PGlcNAc mutase, PGM3, Phospho-N-acetylglucosamine mutase, phosphoacetylglucosamine mutase 1, Phosphomutase, acetylglucosamine
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General Information
General Information on EC 5.4.2.3 - phosphoacetylglucosamine mutase
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evolution
malfunction
loss-of-function mutations in the nst gene, which encodes PGM3, block fibroblast growth factor signaling during embryonic mesoderm and tracheal development. In nst mutants with an 80% reduction in the amount of UDP-GlcNAc, O-GlcNAcylation is compromised. Embryos maternally and zygotically mutant for nst exhibit defects in mesoderm layer formation during gastrulation that are similar to those observed in embryos with mutations in the gene encoding the fibroblast growth factor receptor Heartless (Htl). Zygotic nst mutants (nstZ) exhibit normal dorsal mesoderm differentiation, embryos homozygous for the hypomorphic htlYY262 allele show a reduction in dorsal mesoderm. Phenotypes, overview. Dof is the critical component in MAPK activation affected in nst mutants
metabolism
Nst acts downstream of fibroblast growth factor receptor signaling
physiological function
the enzyme belongs to the alpha-D-phosphohexomutase superfamily of enzymes
evolution
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the enzyme belongs to the alpha-D-phosphohexomutase superfamily of enzymes
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the enzyme is essential for parasite growth. It takes over the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
physiological function
the enzyme is required for normal cellular levels of UDP-GlcNAc and essential in UDP-GlcNAc biosynthesis, and for fibroblast growth factor signaling in early embryos. Role for Nst in fibroblast growth factor receptor Heartless (Htl) signaling
physiological function
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the enzyme is essential for parasite growth. It takes over the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphomannomutase, EC 5.4.2.8, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview
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