5.4.2.3: phosphoacetylglucosamine mutase

This is an abbreviated version!
For detailed information about phosphoacetylglucosamine mutase, go to the full flat file.

Word Map on EC 5.4.2.3

Reaction

N-acetyl-alpha-D-glucosamine 1-phosphate
=
N-acetyl-D-glucosamine 6-phosphate

Synonyms

Acetylglucosamine phosphomutase, Phosphomutase, acetylglucosamine, Acetylaminodeoxyglucose phosphomutase, Phospho-N-acetylglucosamine mutase, PGlcNAc mutase, 2-Acetamido-2-deoxy-D-glucose-1,6-bisphosphate:2-acetamido-2-deoxy-D-glucose 1-phosphate phosphotransferase, EC 2.7.5.2., DNA-damage-repair/toleration protein DRT101, N-acetylglucosamine-phosphate mutase, PAGM, HsAGM1, CaAGM1, AGM1, PGM3, AGM, AGM1/PGM3, phosphoacetylglucosamine mutase 1

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.2 Phosphotransferases (phosphomutases)
                5.4.2.3 phosphoacetylglucosamine mutase

Crystallization

Crystallization on EC 5.4.2.3 - phosphoacetylglucosamine mutase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
both in apo form and in the complex forms with substrate and product. Protein consists of four domains. of which three domains have essentially the same fold. The catalytic cleft is formed by four loops from each domains. The N-acetyl group of the substrate is recognized by V370 and N389 in domain 3, from which the substrate specificity arises. Substrate rotates about 180° on the axis linking C4 and the midpoint of the C5-O5 bond in the reaction
space group P21, crystal diffract to beyond 1.8 A
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