5.4.2.10: phosphoglucosamine mutase

This is an abbreviated version!
For detailed information about phosphoglucosamine mutase, go to the full flat file.

Word Map on EC 5.4.2.10

Reaction

alpha-D-glucosamine 1-phosphate
=
D-glucosamine 6-phosphate

Synonyms

glucosamine phosphomutase, aminodeoxyglucose phosphate phosphomutase, GlmM, MMP1077, phosphoglucosamine mutase, PNGM, alpha-D-glucosamine 1,6-phosphomutase, Aq1627, alpha-phosphoglucoseamine mutase, alpha-PNGM

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.2 Phosphotransferases (phosphomutases)
                5.4.2.10 phosphoglucosamine mutase

Systematic Name

Systematic Name on EC 5.4.2.10 - phosphoglucosamine mutase

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SYSTEMATIC NAME
IUBMB Comments
alpha-D-glucosamine 1,6-phosphomutase
The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis. The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by alpha-D-glucosamine 1,6-bisphosphate, which is an intermediate in the reaction, alpha-D-glucose 1,6-bisphosphate or ATP. It can also catalyse the interconversion of alpha-D-glucose 1-phosphate and glucose 6-phosphate, although at a much lower rate.