5.4.2.10: phosphoglucosamine mutase

This is an abbreviated version!
For detailed information about phosphoglucosamine mutase, go to the full flat file.

Word Map on EC 5.4.2.10

5.4.2.10

glmm

peptidoglycan

glucosamine-1-phosphate

udp-n-acetylglucosamine

phosphoglucomutase

udp-glcnac

5'-diphospho-n-acetylglucosamine

diadenylate

uridyltransferase

penicillin-binding

mutases

gordonii

c-di-amp

mengin-lecreulx

methicillin

medicine

Reaction

Synonyms

alpha-D-glucosamine 1,6-phosphomutase, alpha-phosphoglucoseamine mutase, alpha-PNGM, aminodeoxyglucose phosphate phosphomutase, Aq1627, GlmM, glucosamine phosphomutase, MMP1077, phosphoglucosamine mutase, PNGM

ECTree

5 Isomerases

5.4 Intramolecular transferases

5.4.2 Phosphotransferases (phosphomutases)

5.4.2.10 phosphoglucosamine mutase

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Results	in table
8	Activating Compound
35272	AA Sequence
4	Application
1	CAS Registry Number
13	Cloned(Commentary)
2	Crystallization (Commentary)
2	Expression
15	General Information
4	Inhibitors
6	KM Value [mM]
1	Localization
3	Metals/Ions
8	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
44	Organism
7	Pathway
20	PDB ID
1	pH Optimum
1	pI Value
3	Posttranslational Modification
12	Protein Variants
11	Purification (Commentary)
1	Reaction
7	Reaction Type
24	Reference
4	Source Tissue
9	Specific Activity [micromol/min/mg]
35	Substrates and Products (Substrate)
6	Subunits
35	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Reaction

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Reaction on EC 5.4.2.10 - phosphoglucosamine mutase

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alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate

The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosynthesis, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis. The enzyme from E. coli is activated by phosphorylation and can be autophosphorylated in vitro by glucosamine 1,6-bisphosphate, which is an intermediate in the reaction, glucose 1,6-bisphosphate or ATP. It can also catalyse the interconversion of glucose 1-phosphate and glucose 6-phosphate, although at a much lower rate