5.3.99.2: Prostaglandin-D synthase
This is an abbreviated version!
For detailed information about Prostaglandin-D synthase, go to the full flat file.
Word Map on EC 5.3.99.2
-
5.3.99.2
-
cerebrospinal
-
arachidonic
-
cox-2
-
csf
-
cyclooxygenase
-
prostanoids
-
lipocalins
-
indomethacin
-
creatinine
-
cystatin
-
mast
-
sleep
-
glomerular
-
seminal
-
allergic
-
leptomeninges
-
aspirin
-
eicosanoids
-
thromboxane
-
leukotriene
-
nonsteroidal
-
plexus
-
nsaid
-
medicine
-
synthase-1
-
subarachnoidal
-
1.14.99.1
-
ventrolateral
-
pgf2alpha
-
transthyretin
-
preoptic
-
rhinorrhea
-
endoperoxide
-
fistula
-
sleep-promoting
-
nephelometric
-
beta2-microglobulin
-
pghs-1
-
arachnoid
-
hydroperoxidase
-
sleep-wake
-
analysis
-
synthesis
-
nutrition
- 5.3.99.2
-
cerebrospinal
-
arachidonic
- cox-2
- csf
-
cyclooxygenase
-
prostanoids
-
lipocalins
- indomethacin
- creatinine
- cystatin
-
mast
- sleep
-
glomerular
-
seminal
-
allergic
- leptomeninges
- aspirin
-
eicosanoids
-
thromboxane
-
leukotriene
-
nonsteroidal
- plexus
-
nsaid
- medicine
- synthase-1
-
subarachnoidal
-
1.14.99.1
-
ventrolateral
-
pgf2alpha
- transthyretin
-
preoptic
- rhinorrhea
-
endoperoxide
-
fistula
-
sleep-promoting
-
nephelometric
- beta2-microglobulin
- pghs-1
-
arachnoid
-
hydroperoxidase
-
sleep-wake
- analysis
- synthesis
- nutrition
Reaction
Synonyms
beta-Trace, Beta-trace protein, betaTP, glutathione dependent prostaglandine D2 synthase, Glutathione-dependent PGD synthetase, glutathione-dependent prostaglandin D2 synthase, Glutathione-independent PGD synthetase, H-PGDS, haematopoietic PGD synthase, haematopoietic prostaglandin D synthase, Hematopoietic prostaglandin D synthase, hematopoietic prostaglandin D2 synthase, HPGDS, Isomerase, prostaglanin R2 D-, L-PGDS, L-prostaglandin D synthase, L-type prostaglandin synthase, lipocalin prostaglandin D synthase, lipocalin type prostaglandin D synthase, lipocalin-prostaglandin D synthase, lipocalin-type PG D synthase, lipocalin-type PGD synthase, lipocalin-type Pgds, lipocalin-type prostaglandin d synthase, lipocalin-type prostaglandin D2 synthase, lipocaline-type prostaglandin D synthase, PGD synthase, PGD-S, PGD2 synthase, PGD2 synthetase, PGDS, PGDS2, PGH-PGD isomerase, PGH2 D-isomerase, Prostaglandin D synthase, Prostaglandin D2 synthase, prostaglandin D2 synthetase, prostaglandin synthase, Prostaglandin-D synthase, Prostaglandin-H2 D-isomerase, Prostaglandin-R-prostaglandin D isomerase, PTGDS
ECTree
5.3.99.2 Prostaglandin-D synthaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 5.3.99.2 - Prostaglandin-D synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
-
lipocalin-type prostaglandin D synthase (beta-trace) is upregulated in the alphaB-crystallin-positive astrocytes in the chronic multiple sclerosis
-
enzyme is found in luminal and glandular epithelial cells and in stroma during late pregnancy
-
enzyme is found in luminal and glandular epithelial cells and in stroma during late pregnancy
-
L-PGDS is constitutively expressed in the epithelium of the glandular base
-
precursor cells of platelets, CMK cells, Dami cells. The activity is undetectable in platelets and appears during differentiation of megakaryoblasts to megakaryocytes
-
CMK86, CMK, CMK11-5 and Dami cells. Expression level is highest in CMK86 cells and is less in CMK cells, CMK11-5 cells and Dami cells in that order
-
human ovarian cancer cells. Prostaglandin synthase and testicular factor SOX9 are expressed at both RNA and protein levels in different types of ovarian tumors, while treatment of these cells with prostaglandin D2 can inhibit their growth and induce apoptosis
-
determination of the correlation between content of enzyme in seminal plasma and on the surface of sperm
-
under serum-starved conditions, prostaglandin D2 production is induced through transcriptional activation of cyclooxygenase COX-2 and lipocalin-type PGD synthase via upstream stimulatory factor USF1
-
of cyclic, pregnant, and pseudopregnant rats. Expression of prostaglandin D synthase or prostacyclin synthase are not influenced by the estrous cycle. Prostaglandion D synthase expression is high during early and maximal at the end of pregnancy. During pseudopregnancy, enzyme is increased in time-dependent manner and maximal at day 5
synthesized mainly at the rough endoplasmic reticulum membrane of arachnoid cells, chorioid plexus cells and oligodendrocytes, and then is secreted into the cerebrospinal fluid as a second major protein
-
enzyme mRNA is up-regulated in mouse model of globoid cell leukodystrophy or Krabbes disease, of Tay-Sachs disease, Sandhoff disease, GM1 gangliosidosis and Niemann-Pick type C1 disease,. Oligodendrocytes of all these mouse models show strong immunoreactivity for enzyme, but not astrocytes or microglia
-
cellular localization of the enzyme changes postnatally. The enzyme is distributed in most neurons of the brain of 1-2 week old rats, whereas it is localized in the oligodendrocytes of adult animals
-
prostaglandin-H2 D-isomerase is produced in the membrane system surrounding the brain and is secreted into the cerebrospinal fluid to become beta-trace
qualitative and quantitative fluctuations of prostaglandin D synthase isoforms from cerebrospinal fluid reflect both major and subtle brain pathophysiology
-
L-PGDS expression in mouse epididymis gradually declines in parallel to the declining concentration of endogenous androgen after castration and increases with the treatment of exogenous testosterone
-
bone-marrow derived macrophage, lung and alveolar macrophage. Treatment with Escherichia coli lipopolysaccharide or Pseudomonas induce enzyme expression. Induction is regulated positively by AP-1 and negatively by p53
-
in normal mucosa the enzyme is only detected in few resident mast cells. In the nasal mucosa of subjects suffering from polyposis the enzyme is detected in mast cells and other large infiltrating inflammatory cells
-
in normal mucosa the enzyme is only detected in few resident mast cells. In the nasal mucosa of subjects suffering from polyposis the enzyme is detected in mast cells and other large infiltrating inflammatory cells
-
lipocalin-type prostaglandin D synthase (beta-trace) is upregulated in the alphaB-crystallin-positive oligodendrocytes in the chronic multiple sclerosis
the enzyme is predominantly expressed in retinal pigment epithelium and actively accumulates in interphotoreceptor matrix
-
the enzyme is synthesized within the epithelial cells of the iris and the ciliary body and is then secreted into the aqueous and vitreous humors, where it accumulates as an active enzyme
-
both L-PGDS mRNA and protein are highly expressed in the interstitial tissue of adult testis. L-PGDS mRNA is first detected on day 30 after birth and exhibits an abundant signal in adult caput and cauda epididymis
