5.3.99.2: Prostaglandin-D synthase
This is an abbreviated version!
For detailed information about Prostaglandin-D synthase, go to the full flat file.
Word Map on EC 5.3.99.2
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5.3.99.2
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cerebrospinal
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arachidonic
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cox-2
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csf
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cyclooxygenase
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prostanoids
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lipocalins
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indomethacin
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creatinine
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cystatin
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mast
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sleep
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glomerular
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seminal
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allergic
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leptomeninges
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aspirin
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eicosanoids
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thromboxane
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leukotriene
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nonsteroidal
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plexus
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nsaid
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medicine
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synthase-1
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subarachnoidal
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1.14.99.1
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ventrolateral
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pgf2alpha
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transthyretin
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preoptic
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rhinorrhea
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endoperoxide
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fistula
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sleep-promoting
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nephelometric
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beta2-microglobulin
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pghs-1
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arachnoid
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hydroperoxidase
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sleep-wake
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analysis
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synthesis
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nutrition
- 5.3.99.2
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cerebrospinal
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arachidonic
- cox-2
- csf
-
cyclooxygenase
-
prostanoids
-
lipocalins
- indomethacin
- creatinine
- cystatin
-
mast
- sleep
-
glomerular
-
seminal
-
allergic
- leptomeninges
- aspirin
-
eicosanoids
-
thromboxane
-
leukotriene
-
nonsteroidal
- plexus
-
nsaid
- medicine
- synthase-1
-
subarachnoidal
-
1.14.99.1
-
ventrolateral
-
pgf2alpha
- transthyretin
-
preoptic
- rhinorrhea
-
endoperoxide
-
fistula
-
sleep-promoting
-
nephelometric
- beta2-microglobulin
- pghs-1
-
arachnoid
-
hydroperoxidase
-
sleep-wake
- analysis
- synthesis
- nutrition
Reaction
Synonyms
beta-Trace, Beta-trace protein, betaTP, glutathione dependent prostaglandine D2 synthase, Glutathione-dependent PGD synthetase, glutathione-dependent prostaglandin D2 synthase, Glutathione-independent PGD synthetase, H-PGDS, haematopoietic PGD synthase, haematopoietic prostaglandin D synthase, Hematopoietic prostaglandin D synthase, hematopoietic prostaglandin D2 synthase, HPGDS, Isomerase, prostaglanin R2 D-, L-PGDS, L-prostaglandin D synthase, L-type prostaglandin synthase, lipocalin prostaglandin D synthase, lipocalin type prostaglandin D synthase, lipocalin-prostaglandin D synthase, lipocalin-type PG D synthase, lipocalin-type PGD synthase, lipocalin-type Pgds, lipocalin-type prostaglandin d synthase, lipocalin-type prostaglandin D2 synthase, lipocaline-type prostaglandin D synthase, PGD synthase, PGD-S, PGD2 synthase, PGD2 synthetase, PGDS, PGDS2, PGH-PGD isomerase, PGH2 D-isomerase, Prostaglandin D synthase, Prostaglandin D2 synthase, prostaglandin D2 synthetase, prostaglandin synthase, Prostaglandin-D synthase, Prostaglandin-H2 D-isomerase, Prostaglandin-R-prostaglandin D isomerase, PTGDS
ECTree
5.3.99.2 Prostaglandin-D synthaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 5.3.99.2 - Prostaglandin-D synthase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + 2 GSH
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + GSSG + 2 H+
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + glutathione
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + glutathione
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
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-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
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-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + glutathione
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + glutathione
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate + glutathione
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + glutathione
-
-
-
?
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
-
?
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
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-
-
?
cumene hydroperoxide + 2 GSH
cumene hydroxide + GSSG + H2O
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-
?
Prostaglandin H2
Prostaglandin D2
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?
additional information
?
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the enzyme may play an important role in both the development and the maturation of sperm
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?
additional information
?
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prostaglandin D synthase isoforms from cerebrospinal fluid vary with brain pathology
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?
additional information
?
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lipocalin-type prostaglandin D synthase is a dual-functional protein, acting as a prostaglandin D2-producing enzyme and a lipid transporter, the enzyme can bind a wide variety of lipophilic molecules
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-
?
additional information
?
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enzyme may play a role in scavenging harmful lipophilic substrates in lysosomal storage disorders
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-
?
additional information
?
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the lipocalin-type prostaglandin D synthase, prostaglandin D2, and prostaglandin D receptor system plays a pivotal role in the regulation of physiological sleep
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?
additional information
?
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the enzyme is bi-functional capable of synthesising D series prostaglandins and acting as a carrier of small lipophilic molecules
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?
additional information
?
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the enzyme is bi-functional capable of synthesising D series prostaglandins and acting as a carrier of small lipophilic molecules
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?
additional information
?
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the enzyme belongs to the lipocalin family, a group of secretory proteins involved in the transport of small lipophilic ligands
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?
additional information
?
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the enzyme belongs to the lipocalin family, a group of secretory proteins involved in the transport of small lipophilic ligands
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?
additional information
?
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the hematopoietic prostaglandin D synthase is the key enzyme for production of the D and J series of prostanoids in the immune system and mast cells
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?
additional information
?
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the lipocalin-type prostaglandin D synthetase is responsible for the biosynthesis of prostaglandin D2 in the central nervous system and the genital organs and is secreted into the cerebrospinal fluid and the seminal plasma as beta-trace that has retinoid binding activity. It is likely that the enzyme is a bifunctional protein that acts as both retinoid transporter and prostaglandin D2-producing enzyme
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?
additional information
?
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glutathione-dependent enzyme is predicted to function somehow in immune and allergic responses
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?
additional information
?
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may be involved in both the maintenance and maturation of the CNS
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?
additional information
?
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the enzyme activity in rat brain exhibits a circadian fluctuation in parallel with the sleep/wake cycle
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?
additional information
?
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increased secretion of prostaglandin D synthase by interleukin-1beta is completely inhibited by prostaglandin E2
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?
additional information
?
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it is proposed that in wild-type vascular smooth muscle cells the enzyme retards cell cycle progression and migration, precluding hyperplasia of the tunica media, and that diabetic cells appear resistant to inhibitory effects of L-PGDS, which may help explain the increased atherosclerosis observed in diabetes
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?
additional information
?
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lipocalin-type prostaglandin synthase-D can stimulate glucose transport approximately 2fold as well as enhance insulin-stimulated glucose transport due to stimulation of insulin-responsive glucose transporter GLUT4 translocation to the plasma membrane. In response to lipocalin-type prostaglandin synthase-D, there is an increase in GLUT1 expression and an increase in hexokinase III expression
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?
