5.3.99.2: Prostaglandin-D synthase

This is an abbreviated version!
For detailed information about Prostaglandin-D synthase, go to the full flat file.

Reaction

Synonyms

beta-Trace, Beta-trace protein, betaTP, glutathione dependent prostaglandine D2 synthase, Glutathione-dependent PGD synthetase, glutathione-dependent prostaglandin D2 synthase, Glutathione-independent PGD synthetase, H-PGDS, haematopoietic PGD synthase, haematopoietic prostaglandin D synthase, Hematopoietic prostaglandin D synthase, hematopoietic prostaglandin D2 synthase, HPGDS, Isomerase, prostaglanin R2 D-, L-PGDS, L-prostaglandin D synthase, L-type prostaglandin synthase, lipocalin prostaglandin D synthase, lipocalin type prostaglandin D synthase, lipocalin-prostaglandin D synthase, lipocalin-type PG D synthase, lipocalin-type PGD synthase, lipocalin-type Pgds, lipocalin-type prostaglandin d synthase, lipocalin-type prostaglandin D2 synthase, lipocaline-type prostaglandin D synthase, PGD synthase, PGD-S, PGD2 synthase, PGD2 synthetase, PGDS, PGDS2, PGH-PGD isomerase, PGH2 D-isomerase, Prostaglandin D synthase, Prostaglandin D2 synthase, prostaglandin D2 synthetase, prostaglandin synthase, Prostaglandin-D synthase, Prostaglandin-H2 D-isomerase, Prostaglandin-R-prostaglandin D isomerase, PTGDS

ECTree

     5 Isomerases

         5.3 Intramolecular oxidoreductases

             5.3.99 Other intramolecular oxidoreductases

                5.3.99.2 Prostaglandin-D synthase

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Results	in table
32	Activating Compound
276	AA Sequence
32	Application
1	CAS Registry Number
54	Cloned(Commentary)
14	Cofactor
14	Crystallization (Commentary)
1617	Disease/ Diagnostics
12	Expression
24	General Information
2	General Stability
89	IC50 Value
211	Inhibitors
13	kcat/KM [mM/s]
16	Ki Value [mM]
47	KM Value [mM]
22	Localization
5	Metals/Ions
23	Molecular Weight [Da]
75	Natural Substrates/ Products (Substrates)
278	Organism
8	Pathway
137	PDB ID
8	pH Optimum
4	pH Stability
2	pI Value
5	Posttranslational Modification
80	Protein Variants
37	Purification (Commentary)
1	Reaction
14	Reaction Type
139	Reference
2	Renatured (Commentary)
155	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
113	Substrates and Products (Substrate)
22	Subunits
153	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
7	Temperature Stability [°C]
19	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 5.3.99.2 - Prostaglandin-D synthase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.1

1-benzoyl piperazine

Homo sapiens

O60760

larger than 0.100 mM

703559

0.1

1-benzoyl piperidine

Homo sapiens

O60760

larger than 0.100 mM

703559

0.1

1-benzoyl-4-(methylsulfonyl)piperazine

Homo sapiens

O60760

larger than 0.100 mM

703559

0.1

1-phenyl-1-(2-thienyl)methanamine

Homo sapiens

O60760

larger than 0.100 mM

703559

7

2'-oxo-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]-1',2'-dihydro[2,4'-bipyridine]-5-carboxamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.0362

2-(2'-benzothiazolyl)-5-styryl-3-(4'-phthalhydrazyl) tetrazolium chloride

Homo sapiens

-

IC50: 0.0362 mM in presence of EDTA, 0.0981 in presence of Mg2+

662057

0.000021

2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole

Homo sapiens

O60760

37°C

693542

0.0007

2-phenyl-5-(1H-pyrazol-3-yl)thiazole

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.00004

3-(3-cyclopropyl-1H-pyrazol-4-yl)-N-ethyl-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxamide

Homo sapiens

-

pH and temperature not specified in the publication

748543

0.017

3-(3-cyclopropyl-1H-pyrazol-4-yl)pyridine

Homo sapiens

-

pH and temperature not specified in the publication

748543

0.0003

3-acetamido-N-[5-(1H-indol-4-yl)pyridin-3-yl]propanamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.0875

3-benzoylpyrrole

Homo sapiens

O60760

-

703559

0.00092

3-phenyl-5-(1H-pyrazol-3-yl)-1,2-oxazole

Homo sapiens

O60760

37°C

693542

0.00018

4-(dimethylamino)-N-[5-(1H-indol-4-yl)pyridin-3-yl]butanamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.003

4-dibenzo [a,d]cyclohepten-5-ylidene-1-[4-(2H-tetrazol-5-yl)-butyl]-piperidine

Homo sapiens

-

inhibition of enzyme in lipocalin-type prostaglandin-D synthase-expressing TE-671 cells after stimulation with Ca2+-ionophore A23187

693254

0.000138 - 0.0014

4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid

2 entries

0.0019

5-(3-aminophenyl)-N-benzhydrylthiophene-2-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.023

5-amino-4-[[(3'-hydroxybiphenyl-4-yl)carbonyl]amino]-5-oxopentanoic acid

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.000071

6'-oxo-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]-1',6'-dihydro[2,2'-bipyridine]-5-carboxamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.00006

6-(3-methoxyphenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.00059

6-(3-oxopiperazin-1-yl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.00032

6-(morpholin-4-yl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.000048

6-(piperidin-1-yl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.00023

6-(pyrrolidin-1-yl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.000031

6-phenoxy-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.1

AB179670

Homo sapiens

O60760

larger than 0.100 mM

703559

0.0237

anthralin

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0622

benzophenone

Homo sapiens

O60760

-

703559

0.012

bithionate sodium

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0132

bromocriptine mesylate

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0055

candesartan cilextil

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0017

chlorophyllide copper complex sodium salt

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0002

Cibacron blue 3GA

Homo sapiens

O60760

-

703559

0.117

CMB5190724

Homo sapiens

O60760

-

703559

0.1

CMB5256165

Homo sapiens

O60760

larger than 0.100 mM

703559

0.1

cyclohexyl-phenylketone

Homo sapiens

O60760

larger than 0.100 mM

703559

0.016

cyclopentyl-phenylketone

Homo sapiens

O60760

-

703559

0.0086

deoxycorticosterone acetate

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0084

epirubicin hydrochloride

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0002

erythrosine sodium

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.044 - 0.1223

Ethacrynic acid

2 entries

0.0134

fluorescein

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0089

Hexachlorophene

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0018 - 0.0059

HQL-79

3 entries

0.0018

iopanic acid

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0203

Ketoprofen

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0033

merbromin

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.002

montelukast sodium

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0046

N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.0248

N-(1-amino-1-oxo-3-phenylpropan-2-yl)-3,3'-dihydroxybiphenyl-4-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.0037

N-(1-amino-1-oxo-3-phenylpropan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.0012

N-(1-amino-1-oxo-3-phenylpropan-2-yl)-6-(thiophen-2-yl)nicotinamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.001

N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-3'-hydroxybiphenyl-4-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.0021

N-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.0013

N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.0071

N-(1-amino-4-methyl-1-oxopentan-2-yl)-5-(3-hydroxyphenyl)-thiophene-2-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.008

N-(2-amino-2-oxoethyl)-5-(3-hydroxyphenyl)thiophene-2-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.0108

N-(diphenylmethyl)-2-(3-hydroxyphenyl)-1,3-thiazole-4-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.0007

N-benzhydryl-5-(3-hydroxyphenyl)thiophene-2-carboxamide

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.0085

N-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Homo sapiens

-

pH and temperature not specified in the publication

748543

0.0005

N-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Homo sapiens

-

pH and temperature not specified in the publication

748543

0.1

N-phenyl-2-thiophene-carboxamide

Homo sapiens

O60760

larger than 0.100 mM

703559

0.000075

N-[4-methyl-3-[([3-[(4-methylpiperazin-1-yl)methyl]phenyl]carbonyl)amino]phenyl]-3-phenylisothiazole-5-carboxamide

Homo sapiens

O60760

37°C

693542

0.0012

N-[5-(1H-indol-4-yl)pyridin-3-yl]-2-(1-methyl-1H-imidazol-5-yl)acetamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.000043

N-[5-(1H-indol-4-yl)pyridin-3-yl]-2-(1H-tetrazol-1-yl)acetamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.00013

N-[5-(1H-indol-4-yl)pyridin-3-yl]-3-(piperidin-1-yl)propanamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.000026

N-[5-(1H-indol-4-yl)pyridin-3-yl]-3-(pyridin-3-yl)propanamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.000035

N-[5-(1H-indol-4-yl)pyridin-3-yl]-5-oxopyrrolidine-2-carboxamide (incorrect configuration definition!)

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.000032

N-[5-(1H-indol-4-yl)pyridin-3-yl]propanamide

Homo sapiens

O60760

at 37°C, pH not specified in the publication

747270

0.029

nisoldipine

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.065

nocodazole

Homo sapiens

O60760

-

703559

0.105

NSC151248

Homo sapiens

O60760

-

703559

0.0092

NSC4502

Homo sapiens

O60760

-

703559

0.3

oxfendazole

Homo sapiens

O60760

larger than 0.300 mM

703559

0.0208

pararosaniline pamoate

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0128

phenyl(thiophen-2-yl)methanone

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.1

phenyl-(2-thienyl)-methanol

Homo sapiens

O60760

larger than 0.100 mM

703559

0.0114

phenyl-(3-thienyl)-methanone

Homo sapiens

O60760

-

703559

0.0172

pyrvinium pamoate

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0006

sanguinarine sulfate

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0393

sennoside A

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.027

Sulfobromophthalein

Homo sapiens

O60760

-

703559

0.0003

suramin

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0004

Tannic acid

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.0137

tranilast

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.000138

4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid

Homo sapiens

O60760

37°C

693542

0.0014

4-[[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino]-2-hydroxybenzoic acid

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.044

Ethacrynic acid

Homo sapiens

O60760

at pH 6.5 and 30°C

747503

0.1223

Ethacrynic acid

Homo sapiens

O60760

-

703559

0.0018

HQL-79

Homo sapiens

O60760

-

703559

0.0038

HQL-79

Homo sapiens

-

in 0.1 M Tris-HCl, pH 8.0, at 25°C

715845

0.0059

HQL-79

Homo sapiens

-

pH and temperature not specified in the publication

713649