5.3.3.2: isopentenyl-diphosphate DELTA-isomerase
This is an abbreviated version!
For detailed information about isopentenyl-diphosphate DELTA-isomerase, go to the full flat file.
Word Map on EC 5.3.3.2
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5.3.3.2
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isoprenoids
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mevalonate
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farnesyl
-
geranyl
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geranylgeranyl
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isoprene
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isomerases
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phosphomevalonate
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prenyltransferase
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methylerythritol
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haematococcus
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synthesis
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carbocationic
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1-deoxy-d-xylulose-5-phosphate
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biotechnology
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industry
- 5.3.3.2
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isoprenoids
- mevalonate
-
farnesyl
-
geranyl
-
geranylgeranyl
- isoprene
- isomerases
- phosphomevalonate
- prenyltransferase
- methylerythritol
- haematococcus
- synthesis
-
carbocationic
- 1-deoxy-d-xylulose-5-phosphate
- biotechnology
- industry
Reaction
Synonyms
fcd1, FNI, IDI, IDI-1, Idi-2, IDI1, IDP isomerase, IPI, IPI1, IPP isomerase, IPP-isomerase, IPP:DMAPP, IPPI, IPPI1, IPPI2, IPPISOM, Isomerase, isopentenylpyrophosphate DELTA-, Isopententenyl diphosphate:dimethylallyl diphosphate isomerase, isopentenyl diphosphate isomerase, isopentenyl diphosphate isomerase 1, isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Isopentenyl pyrophosphate isomerase:dimethylallyl pyrophosphate isomerase, isopentenyl-diphosphate delta-isomerase 1, Isopentenyldiphosphate DELTA-isomerase, Isopentenylpyrophosphate isomerase, Methylbutenylpyrophosphate isomerase, SlIPI, type 1 IPP isomerase, type 2 isopentenyl diphosphate isomerase, type 2 isopentenyl diphosphate: dimethylallyl diphosphate isomerase, type 2 isopentenyl diphosphate:dimethylallyl diphosphate isomerase, type 2 isopentenyl-diphosphate isomerase, type I isopentenyl diphosphate isomerase, type II isopentenyl diphosphate isomerase, type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase, type-2 isopentenyl diphosphate isomerase, type-I isopentenyl pyrophosphate isomerase
ECTree
5.3.3.2 isopentenyl-diphosphate DELTA-isomeraseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 5.3.3.2 - isopentenyl-diphosphate DELTA-isomerase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(Z)-3-(difluoromethyl)-2-buten-1-yl diphosphate
?
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about 2% of the activity with isopenteyl diphosphate
-
-
?
(Z)-3-(fluoromethyl)-2-buten-1-yl diphosphate
?
-
about 2% of the activity with isopenteyl diphosphate
-
-
?
3-(fluoromethyl)-3-buten-1-yl diphosphate
?
-
competition between isomerization and alkylation of the flavin cofactor
-
-
?
3-cyclopropyl-3-buten-1-yl diphosphate
(2Z)-3-cyclopropylbut-2-en-1-yl diphosphate
-
-
-
-
r
3-methylene-4-penten-1-yl diphosphate
?
-
competition between isomerization and alkylation of the flavin cofactor
-
-
?
trans-3-Methylpent-3-enyl diphosphate
trans-3-Methylpent-2-enyl diphosphate
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r
-
?
Isopentenyl diphosphate
?
-
essential activation step in isoprenoid biosynthetic pathway
-
-
?
isopentenyl diphosphate
dimethylallyl diphosphate
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steady-state equilibrium ratio of isopentenyl diphosphate/dimethylallyl diphosphate of approximately 1:7
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-
r
isopentenyl diphosphate
dimethylallyl diphosphate
-
-
-
?
isopentenyl diphosphate
dimethylallyl diphosphate
the enzyme catalyzes a crucial activation step in the isoprenoid biosynthesis pathway
-
?
isopentenyl diphosphate
dimethylallyl diphosphate
-
-
-
-
?
isopentenyl diphosphate
dimethylallyl diphosphate
-
-
-
?
isopentenyl diphosphate
dimethylallyl diphosphate
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the enzyme catalyzes the interconversion of the fundamental five carbon homoallylic and allylic diphosphate building blocks required for biosynthesis of isoprenoid compounds
-
?
isopentenyl diphosphate
dimethylallyl diphosphate
-
-
-
?
isopentenyl diphosphate
dimethylallyl diphosphate
-
-
-
?
isopentenyl diphosphate
dimethylallyl diphosphate
a mechanism is proposed where the reduced flavin cofactor acts as a general acid/base catalyst and helps stabilize the carbocationic intermediate formed by protonation
-
-
?
isopentenyl diphosphate
dimethylallyl diphosphate
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the enzyme catalyses the interconversion of isopentenyl diphosphate and dimethylallyl diphosphate with a rather low degree of stereochemical fidelity. At least three kinetically distinguishable exchange processes are detected
-
?
isopentenyl diphosphate
dimethylallyl diphosphate
-
accumulation of a reduced neutral dihydroflavin intermediate upon incubation of the reduced enzyme with isopentenyl diphosphate or dimethylallyl diphosphate. The intermediate forms and decays at kinetically competent rates in the pre-steady-state
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-
r
isopentenyl diphosphate
dimethylallyl diphosphate
-
-
-
-
r
isopentenyl diphosphate
dimethylallyl diphosphate
-
-
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r
additional information
?
-
Cinchona robusta
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induced after addition of a homogenate of the phytopathogenic fungus Phytophthora cinnamomi. Enzyme may be involved in the biosynthesis of anthraquinone phytoalexins that accumulate rapidly after elicitation of Cinchona cells
-
-
?
additional information
?
-
-
zinc is located in an unusual six-coordinate pocket and may facilitate protonation of the unactivated carbon-carbon double bond in isopentenyl diphosphate. The sulfhydryl moiety C67, perhaps in the thiolate form, is in position to remove a proton from the resulting tertiary carbocation to complete the reaction
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?
additional information
?
-
-
key enzyme in biosynthesis of isoprenoids
-
?
additional information
?
-
key enzyme in biosynthesis of isoprenoids
-
?
additional information
?
-
-
key enzyme in biosynthesis of isoprenoids
-
?
additional information
?
-
-
3-butyn-1-yl diphosphate and 2,3-butadien-1-yl diphosphate are no substrates for IDI-1
-
-
?
additional information
?
-
-
enzyme in the pathway of conversion of isopentenyl diphosphate to phytoene
-
-
?
additional information
?
-
the enzyme also has NADH dehydrogenase activity although it catalyzes the isomerase reaction without consuming any detectable amount of NADH. O2 acts as electron acceptor in the NADH dehydrogenase reaction
-
?
additional information
?
-
-
the enzyme also has NADH dehydrogenase activity although it catalyzes the isomerase reaction without consuming any detectable amount of NADH. O2 acts as electron acceptor in the NADH dehydrogenase reaction
-
?
additional information
?
-
-
enzyme in the pathway of conversion of isopentenyl diphosphate to phytoene
-
-
?
additional information
?
-
-
substrate binds to the inactive oxidized and active reduced form of enzyme with similar affinities. Substrate-dependent accumulation of the neutral flavin semiquinone during both the flavoenzyme reduction and reoxidation processes
-
-
?
additional information
?
-
-
3-butyn-1-yl diphosphate and 2,3-butadien-1-yl diphosphate are no substrates for IDI-2
-
-
?
additional information
?
-
-
ìsoform IDI-2 catalyzes exchange of the vinyl hydrogens in 1-OPP without concomitant isomerization
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-
?
