5.3.1.8: mannose-6-phosphate isomerase

This is an abbreviated version!
For detailed information about mannose-6-phosphate isomerase, go to the full flat file.

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Synonyms

BceA, BceAJ, becA, CHLNCDRAFT_139231, D-mannose-6-phosphate ketol-isomerase, GTMpi, Isomerase, mannose phosphate, KB1_0553, M6PI, ManA, Mannose phosphate isomerase, mannose-6-phosphate isomerase, MPI, Os01g0127900, Os09g0389000, PH0925, Phosphohexoisomerase, Phosphohexomutase, Phosphomannoisomerase, Phosphomannose isomerase, phosphomannose-isomerase, Phosphphexomutase, PMI, PMI/GMP, Pmi1, PMI2, PslB, type I phosphomannose isomerase, type I PMI

ECTree

     5 Isomerases

         5.3 Intramolecular oxidoreductases

             5.3.1 Interconverting aldoses and ketoses, and related compounds

                5.3.1.8 mannose-6-phosphate isomerase

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Results	in table
6	Activating Compound
25929	AA Sequence
23	Application
1	CAS Registry Number
38	Cloned(Commentary)
10	Crystallization (Commentary)
241	Disease/ Diagnostics
18	General Information
1	General Stability
10	IC50 Value
139	Inhibitors
30	kcat/KM [mM/s]
18	Ki Value [mM]
80	KM Value [mM]
91	Metals/Ions
46	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
130	Organism
17	Pathway
27	PDB ID
23	pH Optimum
9	pH Range
4	pH Stability
3	pI Value
103	Protein Variants
17	Purification (Commentary)
6	Reaction
4	Reaction Type
124	Reference
33	Source Tissue
85	Specific Activity [micromol/min/mg]
1	Storage Stability
165	Substrates and Products (Substrate)
34	Subunits
83	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
3	Temperature Range [°C]
24	Temperature Stability [°C]
44	Turnover Number [1/s]

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SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

3 - 23

beta-D-mannose 6-phosphate

2 entries

141

D-fructose 6-phosphate

Thermus thermophilus

Q5SIM4

wild type enzyme, pH 7.0, 80°C

714372

7089

D-Lyxose

Bacillus subtilis

Q9AGZ4

pH 7.5, 40°C, recombinant enzyme

701797

3748

D-mannose

Bacillus subtilis

Q9AGZ4

pH 7.5, 40°C, recombinant enzyme

701797

0.076 - 112100

D-mannose 6-phosphate

26 entries

72

D-ribose

Bacillus subtilis

Q9AGZ4

pH 7.5, 40°C, recombinant enzyme

701797

63970

D-talose

Bacillus subtilis

Q9AGZ4

pH 7.5, 40°C, recombinant enzyme

701797

920

L-allose

Bacillus subtilis

Q9AGZ4

pH 7.5, 40°C, recombinant enzyme

701797

17600

L-ribose

Bacillus subtilis

Q9AGZ4

pH 7.5, 40°C, recombinant enzyme

701797

32670 - 81060

L-ribulose

7 entries

121 - 162

mannose 6-phosphate

2 entries

3 - 6

beta-D-mannose 6-phosphate

Homo sapiens

-

in 50 mM HEPES buffer, pH 7.1, at 25°C

716883

23

beta-D-mannose 6-phosphate

Escherichia coli

-

in 50 mM HEPES buffer, pH 7.1, at 25°C

716883

0.076

D-mannose 6-phosphate

Pseudomonas aeruginosa

-

pH 7.1, 25°C

661119

0.25

D-mannose 6-phosphate

Pseudomonas aeruginosa

-

mutant R472A, pH 7.0, 25°C

692361

0.54

D-mannose 6-phosphate

Pseudomonas aeruginosa

-

mutant R479A, pH 7.0, 25°C

692361

0.75

D-mannose 6-phosphate

Pseudomonas aeruginosa

-

mutant R373A, pH 7.0, 25°C

692361

0.84

D-mannose 6-phosphate

Dehalococcoides mccartyi

-

pH 7.5, 30°C

748577

1.38

D-mannose 6-phosphate

Pseudomonas aeruginosa

-

wild-type, pH 7.0, 25°C

692361

2.63

D-mannose 6-phosphate

Pseudomonas aeruginosa

-

mutant E410A, pH 7.0, 25°C

692361

3.25

D-mannose 6-phosphate

Pseudomonas aeruginosa

-

mutant E458A, pH 7.0, 25°C

692361

3.5

D-mannose 6-phosphate

Pseudomonas aeruginosa

-

mutant N433A, pH 7.0, 25°C

692361

4.41

D-mannose 6-phosphate

Pseudomonas aeruginosa

-

mutant H411A, pH 7.0, 25°C

692361

11

D-mannose 6-phosphate

Thermus thermophilus

Q5SIM4

mutant enzyme W13A, pH 7.0, 80°C

714372

19

D-mannose 6-phosphate

Thermus thermophilus

Q5SIM4

mutant enzyme E132A, pH 7.0, 80°C

714372

19.4

D-mannose 6-phosphate

Burkholderia cepacia

Q06XM8

pH 7.6, presence of 5 mM Mg2+

671785

19.4

D-mannose 6-phosphate

Burkholderia cepacia

Q06XM8

pH 7.6, 5 mM Mg2+, temperature not specified in the publication

746961

20

D-mannose 6-phosphate

Saccharomyces cerevisiae

-

pH 7.1, 25°C

661119

31

D-mannose 6-phosphate

Thermus thermophilus

Q5SIM4

mutant enzyme E67A, pH 7.0, 80°C

714372

37

D-mannose 6-phosphate

Thermus thermophilus

Q5SIM4

mutant enzyme Q48A, pH 7.0, 80°C

714372

54

D-mannose 6-phosphate

Thermus thermophilus

Q5SIM4

mutant enzyme H50A, pH 7.0, 80°C

714372

70

D-mannose 6-phosphate

Thermus thermophilus

Q5SIM4

mutant enzyme R142A, pH 7.0, 80°C

714372

75

D-mannose 6-phosphate

Thermus thermophilus

Q5SIM4

mutant enzyme H122A, pH 7.0, 80°C

714372

1371

D-mannose 6-phosphate

Thermus thermophilus

Q5SIM4

wild type enzyme, pH 7.0, 80°C

714372

23550

D-mannose 6-phosphate

Geobacillus thermodenitrificans

A4ITT1

wild type enzyme, at pH 7.0 and 70°C

726723

55120

D-mannose 6-phosphate

Geobacillus thermodenitrificans

A4ITT1

mutant enzyme L129F, at pH 7.0 and 70°C

726723

85720

D-mannose 6-phosphate

Geobacillus thermodenitrificans

A4ITT1

mutant enzyme N90A/L129F, at pH 7.0 and 70°C

726723

106000

D-mannose 6-phosphate

Bacillus amyloliquefaciens

-

pH 7.5, 70°C

749059

112100

D-mannose 6-phosphate

Geobacillus thermodenitrificans

A4ITT1

mutant enzyme W17Q/N90A/L129F, at pH 7.0 and 70°C

726723

32670

L-ribulose

Thermus thermophilus

-

mutant enzyme R142E, at pH 7.0 and 75°C

713854

48300

L-ribulose

Thermus thermophilus

-

mutant enzyme R142Q, at pH 7.0 and 75°C

713854

50640

L-ribulose

Thermus thermophilus

-

wild type enzyme, at pH 7.0 and 75°C

713854

56180

L-ribulose

Thermus thermophilus

-

mutant enzyme R142Y, at pH 7.0 and 75°C

713854

64870

L-ribulose

Thermus thermophilus

-

mutant enzyme R142A, at pH 7.0 and 75°C

713854

68880

L-ribulose

Thermus thermophilus

-

mutant enzyme R142K, at pH 7.0 and 75°C

713854

81060

L-ribulose

Thermus thermophilus

-

mutant enzyme R142N, at pH 7.0 and 75°C

713854

121

mannose 6-phosphate

Candida albicans

-

selenomethionine-labelled enzyme

2825

162

mannose 6-phosphate

Candida albicans

-

wild-type enzyme

2825