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5.3.1.8: mannose-6-phosphate isomerase

This is an abbreviated version!
For detailed information about mannose-6-phosphate isomerase, go to the full flat file.

Word Map on EC 5.3.1.8

Reaction

D-mannose 6-phosphate
=
D-fructose 6-phosphate

Synonyms

BceA, BceAJ, becA, CHLNCDRAFT_139231, D-mannose-6-phosphate ketol-isomerase, GTMpi, Isomerase, mannose phosphate, KB1_0553, M6PI, ManA, Mannose phosphate isomerase, mannose-6-phosphate isomerase, MPI, Os01g0127900, Os09g0389000, PH0925, Phosphohexoisomerase, Phosphohexomutase, Phosphomannoisomerase, Phosphomannose isomerase, phosphomannose-isomerase, Phosphphexomutase, PMI, PMI/GMP, Pmi1, PMI2, PslB, type I phosphomannose isomerase, type I PMI

ECTree

     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.1 Interconverting aldoses and ketoses, and related compounds
                5.3.1.8 mannose-6-phosphate isomerase

Temperature Stability

Temperature Stability on EC 5.3.1.8 - mannose-6-phosphate isomerase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100
-
melting temperature for thermal unfolding, 60 min, 50% residual activity
25
purified recombinant enzyme, half-life is 461 h
28
-
half-life in absence of Zn2+: 110 min, half-life in presence of 0.0002 mM ZnCl2: 270 min
30
purified recombinant enzyme, half-life is 325 h
35
purified recombinant enzyme, half-life is 236 h
37
-
6 min, wild-type enzyme stable, mutant enzyme loses about 90% of activity
55
-
pH 6.5, 10 min, about 75% loss of native enzyme
64 - 85
the half-lives of the enzyme at 65, 70, 75, 80, and 85°C are 13, 6.5, 3.7, 1.8, and 0.2 h, respectively
65
-
enzyme half-life is 73 h
65 - 85
-
the enzyme shows half-lives of 22, 10, 5.5, 2.1, and 0.3 h at 65, 70, 75, 80, and 85°C, respectively
70
-
enzyme half-life is 27 h
additional information