5.3.1.8: mannose-6-phosphate isomerase
This is an abbreviated version!
For detailed information about mannose-6-phosphate isomerase, go to the full flat file.
Word Map on EC 5.3.1.8
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5.3.1.8
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phosphomannomutase
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gdp-mannose
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pyrophosphorylase
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phosphoglucomutase
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fructose-6-phosphate
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phosphoglucose
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enteropathy
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carbohydrate-deficient
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viannia
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allozyme
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braziliensis
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chlorophenol
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mannose-containing
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man-6-p
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phosphoglucoisomerase
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biolistic
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protein-losing
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l-ribose
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peruviana
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synthesis
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thermodenitrificans
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guyanensis
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biotechnology
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agriculture
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pharmacology
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analysis
- 5.3.1.8
- phosphomannomutase
- gdp-mannose
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pyrophosphorylase
- phosphoglucomutase
- fructose-6-phosphate
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phosphoglucose
- enteropathy
-
carbohydrate-deficient
- viannia
-
allozyme
- braziliensis
- chlorophenol
-
mannose-containing
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man-6-p
- phosphoglucoisomerase
-
biolistic
-
protein-losing
- l-ribose
- peruviana
- synthesis
- thermodenitrificans
-
guyanensis
- biotechnology
- agriculture
- pharmacology
- analysis
Reaction
Synonyms
BceA, BceAJ, becA, CHLNCDRAFT_139231, D-mannose-6-phosphate ketol-isomerase, GTMpi, Isomerase, mannose phosphate, KB1_0553, M6PI, ManA, Mannose phosphate isomerase, mannose-6-phosphate isomerase, MPI, Os01g0127900, Os09g0389000, PH0925, Phosphohexoisomerase, Phosphohexomutase, Phosphomannoisomerase, Phosphomannose isomerase, phosphomannose-isomerase, Phosphphexomutase, PMI, PMI/GMP, Pmi1, PMI2, PslB, type I phosphomannose isomerase, type I PMI
ECTree
5.3.1.8 mannose-6-phosphate isomeraseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 5.3.1.8 - mannose-6-phosphate isomerase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
beta-D-mannose 6-phosphate
beta-D-fructose 6-phosphate
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?
beta-D-mannose 6-phosphate
beta-D-fructose 6-phosphate
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?
D-Fructose 6-phosphate
?
Microorganisms
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mannose 6-phosphate produced in this manner can be incorporated via mannose 1-phosphate as intermediate into guanosine diphosphomannose which participates in numerous processes related to cell wall biosynthesis
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?
D-fructose 6-phosphate
D-mannose 6-phosphate
first step in the biosynthesis of activated mannose donors required for the biosynthesis of various glycoconjugates
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r
D-Mannose 6-phosphate
?
Cassia coluteoides
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enzyme is involved in the utilization of mannose released by hydrolysis of galactomannan on germination after phosphorylation to mannose 6-phosphate
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?
D-Mannose 6-phosphate
?
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channeling D-mannose 6-phosphate into glycolysis by isomerization to fructose 6-phosphate
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?
D-Mannose 6-phosphate
D-Fructose 6-phosphate
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-
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r
D-Mannose 6-phosphate
D-Fructose 6-phosphate
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beta-D-fructose 6-phosphate serves as substrate in the reverse direction
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?
D-Mannose 6-phosphate
D-Fructose 6-phosphate
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highly specific for the beta anomer of mannose 6-phosphate, the alpha anomer has no activity as a substrate, and is, at best, a poor inhibitor
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?
D-Mannose 6-phosphate
D-Fructose 6-phosphate
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r
D-Mannose 6-phosphate
D-Fructose 6-phosphate
best substrate
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r
D-Mannose 6-phosphate
D-Fructose 6-phosphate
best substrate
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r
D-ribose 5-phosphate
D-ribulose 5-phosphate
very low activity
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r
D-ribose 5-phosphate
D-ribulose 5-phosphate
very low activity
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r
additional information
?
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the enzyme is specific for aldose substrates possessing hydroxyl groups oriented in the same direction at the C-2 and C-3 positions, such as the D- and L-enantiomers of ribose, lyxose, talose, mannose, and allose, substrate specificity, overview
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?
additional information
?
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the enzyme is specific for aldose substrates possessing hydroxyl groups oriented in the same direction at the C-2 and C-3 positions, such as the D- and L-enantiomers of ribose, lyxose, talose, mannose, and allose, substrate specificity, overview
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?
additional information
?
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enzyme is involved in biosynthesis of mannan components of the cell walls
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?
additional information
?
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enzyme is involved in biosynthesis of mannan components of the cell walls
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?
additional information
?
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reversible isomerization of mannose 6-phosphate and fructose 6-phosphate is the initial commited step in the synthesis of the mannosylated glycoproteins, which are essential in biosynthesis of functional fungal cell wall. Absence of mannose-6-phosphate isomerase causes cell lysis
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?
additional information
?
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no substrates: D-glucose 6-phosphate, D-fructose 6-phosphate
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?
additional information
?
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Molecular mechanics study of enzyme substrate and inhibitors, overview
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?
additional information
?
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enzyme substrate specificity with diverse monosaccharide aldoses and ketoses, overview
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?
additional information
?
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critical role in the supply of the D-mannose derivatives required for many glycosylation reactions
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?
additional information
?
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Molecular mechanics study of enzyme substrate and inhibitors, overview
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?
additional information
?
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PMI is bifunctional possessing both mannose 6-phosphate isomerase and GDP-mannose diphosphorylase activities
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?
additional information
?
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PMI is bifunctional possessing both mannose 6-phosphate isomerase and GDP-mannose diphosphorylase activities
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?
additional information
?
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no activity with D-glucose 6-phosphate and arabinose 5-phosphate
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?
additional information
?
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no activity with D-glucose 6-phosphate and arabinose 5-phosphate
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?
additional information
?
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no activity with D-glucose 6-phosphate and arabinose 5-phosphate
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?
