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D-allose 6-phosphate
D-allulose 6-phosphate
D-Glucose 6-phosphate
?
-
-
-
-
?
D-ribose 5-diphosphate
D-ribulose 5-diphosphate
D-ribose 5-phosphate
D-ribulose 5-phosphate
D-ribose 5-triphosphate
D-ribulose 5-triphosphate
-
-
?
D-ribose-5-phosphate
D-ribulose-5-phosphate
D-ribulose 5-diphosphate
D-ribose 5-diphosphate
D-ribulose 5-phosphate
D-ribose 5-phosphate
additional information
?
-
D-allose
D-psicose
-
-
-
-
r
D-allose
D-psicose
-
-
-
?
D-allose
D-psicose
-
substrates D-allose and D-psicose are preferred over ribose 5-phosphate
-
-
r
D-allose
D-psicose
-
-
-
?
D-allose
D-psicose
-
-
-
-
r
D-allose
D-psicose
AM180355
the specific activity follows the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
D-allose
D-psicose
-
-
-
-
r
D-allose
D-psicose
AM180355
the specific activity follows the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
D-allose
D-psicose
-
-
-
?
D-allose
D-psicose
-
-
-
-
r
D-allose
D-psicose
the specific activity follows the order L-talose, D-ribose, D-allose, L-allose, L-lyxose, L-ribose, D-tallose
-
-
?
D-allose
D-psicose
the specific activity follows the order L-talose, D-ribose, D-allose, L-allose, L-lyxose, L-ribose, D-tallose
-
-
?
D-allose 6-phosphate
D-allulose 6-phosphate
-
-
-
-
r
D-allose 6-phosphate
D-allulose 6-phosphate
-
-
-
r
D-allose 6-phosphate
D-allulose 6-phosphate
-
-
-
r
D-gulose
D-sorbose
-
-
-
-
r
D-gulose
D-sorbose
AM180355
the specific activity follows the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
D-gulose
D-sorbose
-
-
-
-
r
D-psicose
D-allose
-
substrates D-allose and D-psicose are preferred over ribose 5-phosphate
-
-
r
D-psicose
D-allose
the conversion yield of D-psicose to D-allose is 32% for the R132E mutant enzyme and 25% for the wild type enzyme after 80 min
-
-
r
D-psicose
D-allose
the conversion yield of D-psicose to D-allose is 32% for the R132E mutant enzyme and 25% for the wild type enzyme after 80 min
-
-
r
D-psicose
D-allose
-
-
-
-
r
D-psicose
D-allose
-
the enzyme convertes D-psicose to D-allose maximally at 75°C and pH 8.0 with a 32% conversion yield
-
-
?
D-psicose
D-allose
-
the enzyme convertes D-psicose to D-allose maximally at 75°C and pH 8.0 with a 32% conversion yield
-
-
?
D-psicose
D-allose
-
-
-
-
r
D-ribose
D-ribulose
-
-
-
-
r
D-ribose
D-ribulose
-
-
-
?
D-ribose
D-ribulose
-
-
38% conversion to D-ribose 5-phosphate yield after approximately 90 min
-
r
D-ribose
D-ribulose
-
39% conversion yield after approximately 90 min
-
-
r
D-ribose
D-ribulose
-
-
-
?
D-ribose
D-ribulose
-
-
-
-
r
D-ribose
D-ribulose
AM180355
the specific activity follows the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
D-ribose
D-ribulose
-
-
-
-
r
D-ribose
D-ribulose
AM180355
the specific activity follows the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
D-ribose
D-ribulose
-
-
-
?
D-ribose
D-ribulose
-
-
-
-
r
D-ribose
D-ribulose
the specific activity follows the order L-talose, D-ribose, D-allose, L-allose, L-lyxose, L-ribose, D-tallose
-
-
?
D-ribose
D-ribulose
the specific activity follows the order L-talose, D-ribose, D-allose, L-allose, L-lyxose, L-ribose, D-tallose
-
-
?
D-ribose 5-diphosphate
D-ribulose 5-diphosphate
-
substrates D-allose and D-psicose are preferred over ribose 5-phosphate
-
-
r
D-ribose 5-diphosphate
D-ribulose 5-diphosphate
-
-
?
D-ribose 5-diphosphate
D-ribulose 5-diphosphate
-
-
-
r
D-ribose 5-diphosphate
D-ribulose 5-diphosphate
-
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
preferred substrate
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
preferred substrate
38% conversion to D-ribose 5-phosphate yield after approximately 90 min at 50°C
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
Chromatium sp.
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
AM180355
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
enzyme is involved in the first step of the non-oxidative branch of the pentose phosphate pathway. Two ribose 5-phosphate isomerase, RpiA and RpiB. RpiA is constitutively expressed, accounts for about 99% of the total ribose 5-phosphate isomerase activity for strains grown in nutrient broth. Escherichia coli strains defective in rpiA gene are still able to use ribose as a carbon source due to the presence of the second RPI, a ribose-inducible RpiB
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
the enzyme plays essential roles in carbohydrate anabolism and catabolism
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
the open configuration of ribose 5-phosphate is required for isomerization and is reversibly converted to ribulose 5-phosphate
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
direct or indirect catalytic role for the residues E107, D85 and K98
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
diastereotopic specificity
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
ribose 5-phosphate ketol-isomerase, the translation product of the RKI1 gene plays a crucial role in pyridoxine synthesis in yeast
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
highest specific activity
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
key enzyme in the oxidative and reductive pentose-phosphate pathway for the conversion of ribose-5-phosphate to ribulose-5-phosphatre and vice versa
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
key enzyme in the oxidative and reductive pentose-phosphate pathway for the conversion of ribose-5-phosphate to ribulose-5-phosphatre and vice versa
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
binding mode of substrate, overview
-
-
r
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose 5-phosphate
D-ribulose 5-phosphate
-
-
-
?
D-ribose-5-phosphate
D-ribulose-5-phosphate
-
-
-
?
D-ribose-5-phosphate
D-ribulose-5-phosphate
the cytosolic ribose-5-phosphate isomerase catalyzes the reversible interconversion of ribulose-5-phosphate and ribose-5-phosphate in the non-oxidative phase of the oxidative pentose phosphate pathway
-
-
?
D-ribulose
D-ribose
-
-
-
-
r
D-ribulose
D-ribose
-
-
-
-
r
D-ribulose 5-diphosphate
D-ribose 5-diphosphate
-
-
-
r
D-ribulose 5-diphosphate
D-ribose 5-diphosphate
-
-
-
r
D-ribulose 5-phosphate
D-ribose 5-phosphate
-
-
-
r
D-ribulose 5-phosphate
D-ribose 5-phosphate
-
-
-
r
D-ribulose 5-phosphate
D-ribose 5-phosphate
-
-
-
?
D-ribulose 5-phosphate
D-ribose 5-phosphate
-
-
-
?
D-sorbose
D-gulose
-
-
-
-
r
D-sorbose
D-gulose
-
lowest activity with L-sorbose
-
-
r
D-talose
D-tagatose
-
-
-
-
r
D-talose
D-tagatose
-
-
-
?
D-talose
D-tagatose
-
-
-
?
D-talose
D-tagatose
-
-
-
?
D-talose
D-tagatose
the specific activity follows the order L-talose, D-ribose, D-allose, L-allose, L-lyxose, L-ribose, D-tallose
-
-
?
L-allose
L-psicose
-
-
-
-
r
L-allose
L-psicose
the specific activity follows the order L-talose, D-ribose, D-allose, L-allose, L-lyxose, L-ribose, D-tallose
-
-
?
L-fructose
L-mannose
-
-
-
-
r
L-fructose
L-mannose
-
-
-
-
r
L-lyxose
L-xylulose
-
-
-
-
r
L-lyxose
L-xylulose
AM180355
the specific activity follows the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
L-lyxose
L-xylulose
-
-
-
-
r
L-lyxose
L-xylulose
AM180355
the specific activity follows the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
L-lyxose
L-xylulose
-
particularly high activity with L-lyxose
-
-
r
L-lyxose
L-xylulose
the specific activity follows the order L-talose, D-ribose, D-allose, L-allose, L-lyxose, L-ribose, D-tallose
-
-
?
L-lyxose
L-xylulose
the specific activity follows the order L-talose, D-ribose, D-allose, L-allose, L-lyxose, L-ribose, D-tallose
-
-
?
L-Mannose
L-Fructose
AM180355
the specific activity follows the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
L-Mannose
L-Fructose
AM180355
the specific activity follows the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
L-Mannose
L-Fructose
-
-
-
-
r
L-ribose
L-ribulose
-
-
-
-
r
L-ribose
L-ribulose
the specific activity follows the order L-talose, D-ribose, D-allose, L-allose, L-lyxose, L-ribose, D-tallose
-
-
?
L-tagatose
L-talose
-
-
-
-
r
L-tagatose
L-talose
-
particularly high activity with L-tagatose
-
-
r
L-talose
L-tagatose
-
preferred substrate
-
-
r
L-talose
L-tagatose
-
89% conversion yield after approximately 90 min
-
-
r
L-talose
L-tagatose
-
the enzyme prefers the forward reaction, high activity, 89% conversion to L-tagatose yield after approximately 90 min at 50°C
-
-
r
L-talose
L-tagatose
-
-
-
-
r
L-talose
L-tagatose
AM180355
the specific activity follows the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
L-talose
L-tagatose
-
particularly high activity with L-talose
-
-
r
L-talose
L-tagatose
the specific activity follows the order L-talose, D-ribose, D-allose, L-allose, L-lyxose, L-ribose, D-tallose
-
-
?
L-xylulose
L-lyxose
-
-
-
-
r
L-xylulose
L-lyxose
-
particularly high activity with L-lyxose
-
-
r
additional information
?
-
-
no substrate: D-xylose, L-rhamnose, D-altrose, D-galactose
-
-
?
additional information
?
-
-
CTRPI has a narrow substrate specificity for rare sugars and reversibly converts aldose substrates containing hydroxyl groups oriented in the same direction to one of the corresponding ketoses. CTRPI prefers aldose substrates such as L-talose, D-ribose and D-allose
-
-
?
additional information
?
-
-
RpiB also displays activity with L-talose, D-ribose, D-allose, L-allose, L-ribose, and D-talose in decreasing order. The enzyme shows specificity for aldose substrates possessing hydroxyl groups oriented in the same direction at the C2, C3, and C4 positions. The substrate specificity through substrate interactions with residues Tyr42, His98, and His9, which interact with the hydroxyl groups of C2, C3, and C4, respectively, oriented in the same direction, homology molecular modeling, overview
-
-
?
additional information
?
-
-
enzyme displays activity only with aldose substrates possessing hydroxyl groups oriented in the right-handed configuration (Fischer projections) at the C2 and C3 positions, such as D-ribose, D-allose, L-talose, L-lyxose, D-gulose, and L-mannose. The specific activity decreases in the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
additional information
?
-
AM180355
the enzyme displays activity only with aldose substrates possessing hydroxyl groups oriented in the right-handed configuration (Fischer projections) at the C2 and C3 positions, such as D-ribose, D-allose, L-talose, L-lyxose, D-gulose, and L-mannose
-
-
?
additional information
?
-
-
enzyme displays activity only with aldose substrates possessing hydroxyl groups oriented in the right-handed configuration (Fischer projections) at the C2 and C3 positions, such as D-ribose, D-allose, L-talose, L-lyxose, D-gulose, and L-mannose. The specific activity decreases in the order D-ribose, D-allose, L-talose, L-lyxose, D-gulose, L-mannose
-
-
?
additional information
?
-
AM180355
the enzyme displays activity only with aldose substrates possessing hydroxyl groups oriented in the right-handed configuration (Fischer projections) at the C2 and C3 positions, such as D-ribose, D-allose, L-talose, L-lyxose, D-gulose, and L-mannose
-
-
?
additional information
?
-
-
ribose 5-phosphate isomerase and ribulose-5-phosphate kinase produce and utilize, respectively, a form of ribulose 5-phosphate which is not the predominant form in the aqueous solution. The effect of this specificity will be channelling of ribulose 5-phosphate from the isomerase to the kinase during photosynthesis
-
-
?
additional information
?
-
-
physical interaction between phosphoribulokinase and ribose-5-phosphate isomerase in the presence of substrate can facilitate direct transfer of ribulose 5-phosphate between the two enzymes
-
-
?
additional information
?
-
-
the constitutive ribosephosphate isomerase A catalyzes the formation of ribose 5-phosphate from ribulose 5-phosphate and also participates in the reverse reaction during ribose and adenosine catabolism. The normal physiological role of the inducible ribosephosphate isomerase B is still uncertain
-
-
?
additional information
?
-
-
enzyme substrate synthesis, overview
-
-
?
additional information
?
-
enzyme exhibits activity with D-form of various aldose substrates in the order of D-ribose > D-talose > D-allose > D-arabinose
-
-
?
additional information
?
-
-
enzyme exhibits activity with D-form of various aldose substrates in the order of D-ribose > D-talose > D-allose > D-arabinose
-
-
?
additional information
?
-
no activity with D-allose 6-phosphate
-
-
?
additional information
?
-
-
no activity with D-allose 6-phosphate
-
-
?
additional information
?
-
enzyme substrate synthesis, overview
-
-
?
additional information
?
-
-
enzyme substrate synthesis, overview
-
-
?
additional information
?
-
no activity with D-allose 6-phosphate
-
-
?
additional information
?
-
enzyme substrate synthesis, overview
-
-
?
additional information
?
-
-
the enzyme catalyzes the interconversion of D-ribose-5-phosphate and D-ribulose-5-phosphate in the reductive and oxidative pentose phosphate pathways and thus plays an important role in the primary metabolism of both photosynthetic and non-photosynthetic organisms
-
-
?
additional information
?
-
-
no activity is observed with D-mannose-6-phosphate
-
-
?
additional information
?
-
the enzyme displays activity only with aldose substrates having hydroxyl groups configured in the same direction at the C2, C3, and C4 positions
-
-
?
additional information
?
-
the enzyme displays activity only with aldose substrates having hydroxyl groups configured in the same direction at the C2, C3, and C4 positions
-
-
?
additional information
?
-
the enzyme cannot isomerizes D-allose 6-phosphate
-
-
?
additional information
?
-
-
the enzyme cannot isomerizes D-allose 6-phosphate
-
-
?
additional information
?
-
the enzyme cannot isomerizes D-allose 6-phosphate
-
-
?