5.3.1.6: ribose-5-phosphate isomerase

This is an abbreviated version!
For detailed information about ribose-5-phosphate isomerase, go to the full flat file.

Word Map on EC 5.3.1.6

Reaction

D-ribose 5-phosphate
=
D-ribulose 5-phosphate

Synonyms

Isomerase, ribose phosphate, Phosphopentoisomerase, Phosphopentose isomerase, Phosphoriboisomerase, Ribose phosphate isomerase, 5-Phosphoribose isomerase, D-Ribose 5-phosphate isomerase, Ribose-5-P isomerase, RPI, Ribosephosphate isomerase A, Ribosephosphate isomerase B, D-ribose-5-phosphate ketol-isomerase, D-xylose ketol-isomerase, RpiA, ribose-5-phosphate isomerase B, RpiB, 5-phosphate ketol-isomerase, type B ribose-5-phosphate isomerase, D-ribose-5-phosphate isomerase, D-ribose-5-phosphate isomerase B, D-ribose-5-phosphate isomerase A, CTRPI, MJ1603, type B ribose 5-phosphate isomerase, EcRpiB, type B Rpi, MtRpiB, ribose 5-phosphate isomerase A, RPI2 protein, ribose-5-phosphate isomerase, CTRpiB, SMU2142, ribose-5-phosphate isomerase type B, SMU1234, TM1080, LMJF_28_1970, Tc00.1047053509199.24, LINJ_28_2100

ECTree

     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.1 Interconverting aldoses and ketoses, and related compounds
                5.3.1.6 ribose-5-phosphate isomerase

Application

Application on EC 5.3.1.6 - ribose-5-phosphate isomerase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
RPIA is significantly elevated in colorectal. RPIA modulates cell proliferation and oncogenicity via activation of beta-catenin in colon cancer cell lines. RPIA enters the nucleus to form a complex with the adenomatous polyposis coli and beta-catenin, the association protects beta-catenin by preventing its phosphorylation, ubiquitination, and subsequent degradation. The C-terminus of RPIA (amino acids 290 to 311) is necessary for RPIA-mediated tumorigenesis
synthesis