5.3.1.1: triose-phosphate isomerase
This is an abbreviated version!
For detailed information about triose-phosphate isomerase, go to the full flat file.
Word Map on EC 5.3.1.1
-
5.3.1.1
-
giardia
-
assemblage
-
aldolase
-
duodenalis
-
dihydroxyacetone
-
enolase
-
phosphoglycerate
-
zoonotic
-
barrel
-
fecal
-
trypanosoma
-
multilocus
-
fructose
-
giardiasis
-
dhap
-
cryptosporidium
-
brucei
-
protozoan
-
isomerases
-
gapdh
-
province
-
cysts
-
malate
-
stool
-
lamblia
-
methylglyoxal
-
phosphofructokinase
-
cruzi
-
schistosoma
-
enediolate
-
2-phosphoglycolate
-
parvum
-
hemolytic
-
intestinalis
-
fructose-1,6-bisphosphate
-
deamidation
-
alpha-enolase
-
1,6-bisphosphate
-
glucosephosphate
-
tim-barrel
-
hungarian
-
hominis
-
phosphite
-
dianion
-
phosphoglucose
-
glycosomes
-
enzymopathy
-
fructose-bisphosphate
-
ige-binding
-
subgenotype
-
diagnostics
-
synthesis
-
analysis
-
biofuel production
-
medicine
- 5.3.1.1
- giardia
-
assemblage
- aldolase
- duodenalis
- dihydroxyacetone
- enolase
- phosphoglycerate
-
zoonotic
-
barrel
-
fecal
- trypanosoma
-
multilocus
- fructose
- giardiasis
- dhap
- cryptosporidium
- brucei
-
protozoan
- isomerases
- gapdh
-
province
- cysts
- malate
-
stool
- lamblia
- methylglyoxal
-
phosphofructokinase
- cruzi
- schistosoma
-
enediolate
- 2-phosphoglycolate
- parvum
-
hemolytic
- intestinalis
- fructose-1,6-bisphosphate
-
deamidation
- alpha-enolase
- 1,6-bisphosphate
-
glucosephosphate
-
tim-barrel
-
hungarian
- hominis
- phosphite
-
dianion
-
phosphoglucose
- glycosomes
-
enzymopathy
-
fructose-bisphosphate
-
ige-binding
-
subgenotype
- diagnostics
- synthesis
- analysis
- biofuel production
- medicine
Reaction
Synonyms
CP 25, CTIMC, cTPI, cytoplasmic TPI, cytoplasmic triosephosphate isomerase, cytoTPI, D-glyceraldehyde-3-phosphate ketol-isomerase, GlTIM, Isomerase, triose phosphate, Lactacin B inducer protein, monoTIM, PfTIM, PfuTIM, Phosphotriose isomerase, plastidic TPI, plastidic triosephosphate isomerase, pTPI, SSO2592, TcTIM, TIM, TIM1, TIM2, TonTIM, TpI, TPI1, TpiA, Triose phosphate isomerase, Triose phosphate mutase, Triose phosphoisomerase, Triosephosphate isomerase, Triosephosphate mutase, vTIM
ECTree
Advanced search results
Substrates Products
Substrates Products on EC 5.3.1.1 - triose-phosphate isomerase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
dihydroxyacetone 3-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone 3-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone 3-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone 3-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone 3-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone 3-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
isomerization of D-glyceraldehyde 3-phosphate in D2O proceeds with 49% intramolecular transfer of the 1 H label from substrate to product dihydroxyacetone phosphate
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
the active site of free enzyme, which has an open conformation needed to allow substrate binding, adopts a closed conformation at the enediolate-complex intermediate where the catalytic side chain is sequestered from interaction with imidazole dissolved in D2O
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
cytoplasmic triosephosphate isomerase may be important in the glycolytic pathway for the supply of C to respiratory and biosynthetic pathways during active growth
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
-
r
D-glyceraldehyde 3-phosphate
dihydroxyacetone phosphate
-
-
-
r
D-Glyceraldehyde 3-phosphate
Glycerone phosphate
-
stereospecific reaction via an enzyme-bound enediol(ate) intermediate, proton transfer from D-glyceraldehyde 3-phosphate to the carboxylate side chain of TIM Glu165, irreversible labeling with deuterium , overview
-
-
r
D-Glyceraldehyde 3-phosphate
Glycerone phosphate
the reaction is essential in vivo
-
-
r
D-Glyceraldehyde 3-phosphate
Glycerone phosphate
triosephosphate isomerase is an enolizing enzyme, which catalyses the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate
-
-
r
D-Glyceraldehyde 3-phosphate
Glycerone phosphate
-
TIM is highly specific for the substrates
-
-
r
D-Glyceraldehyde 3-phosphate
Glycerone phosphate
-
-
-
r
D-Glyceraldehyde 3-phosphate
Glycerone phosphate
substrate binding perturbs residues Asn10, His95, Ser100, Glu129-Glu133, Val167-Ala186, Asn213, and Leu230-Leu126 that either are near the ligand or have direct contact with the ligand
-
-
?
D-Glyceraldehyde 3-phosphate
Glycerone phosphate
-
key reaction in glycolysis
-
?
dihydroxyacetone 3-phosphate
D-glyceraldehyde 3-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate
-
-
-
r
dihydroxyacetone phosphate
D-glyceraldehyde 3-phosphate
-
-
-
?
dihydroxyacetone phosphate
D-glyceraldehyde 3-phosphate
-
-
-
?
dihydroxyacetone phosphate
D-glyceraldehyde 3-phosphate
-
-
-
r
dihydroxyacetone phosphate
D-glyceraldehyde 3-phosphate
-
-
-
-
r
glycolaldehyde
?
-
TIM-catalyzed reactions of glycolaldehyde are activated by phosphite dianion, kinetics, overview
-
-
?
?
-
enzyme is confirmed by total proteome analysis of glycerol-grown cells
-
-
?
additional information
?
-
-
enzyme may be involved in integrin alphaIIb/beta3-mediated platelet function
-
-
?
additional information
?
-
the proton transfer reaction from PGH to the Glu167 side chain, when PGH becomes sequestered in the active site, active site modeling, overview
-
-
?
additional information
?
-
-
Tau, main component of the aberrant paired helical filaments found in Alzheimer's disease, interacts with the enzyme and protects TPI against oxidative damage, overview. Interaction between Tau and triose phosphate isomerase occurs in a normal, nondisease state as well as in a neurodegeneration state
-
-
?
additional information
?
-
-
formation of a two-part substrate by carving up D-glyceraldehyde 3-phosphate into the minimal neutral two-carbon sugar glycolaldehyde and phosphite dianion pieces. Enzyme catalyzes proton transfer from glycolaldehyde in D2O with a ratio of kcat to Km of 0.26 per M and s. Addition of exogenous phosphite dianion results in a large increase in the observed second-order rate constant for turnover of glycolaldehyde. Binding of phosphite dianion to the free enzyme is 700fold weaker than its binding to the fleeting complex of the enzyme with the altered substrate in the transition state
-
-
?
additional information
?
-
importance of conserved residues in the vicinity of the active site that serve to position the functional K12 residue. A network of key interactions spans the interacting subunits
-
-
?
additional information
?
-
-
importance of conserved residues in the vicinity of the active site that serve to position the functional K12 residue. A network of key interactions spans the interacting subunits
-
-
?
additional information
?
-
Plasmodium falciparum TIM is unique in possessing a Phe residue at position 96 in place of the conserved Ser that is found in TIMs from the majority of other organisms
-
-
?
additional information
?
-
-
Plasmodium falciparum TIM is unique in possessing a Phe residue at position 96 in place of the conserved Ser that is found in TIMs from the majority of other organisms
-
-
?
additional information
?
-
enzyme is involved in arsenate reduction
-
-
?
additional information
?
-
the effect of bound phosphite dianion on the activation barrier is small, in comparison to the much larger intrinsic phosphodianion and phosphite dianion binding energy utilized to stabilize the transition states for TIM-catalyzed deprotonation of glyceraldehyde-3-phosphate and glyceraldehyde-phosphite dianion complex, respectively
-
-
?
additional information
?
-
the substrate is locked in a protein cage with the phosphodianion occluded from interaction with solvent water, and ion-paired to the surface alkyl ammonium side chain of residue K12. The neutral imidazole side chain of H95 interacts with the carbonyl oxygen of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate
-
-
?
additional information
?
-
the substrate is locked in a protein cage with the phosphodianion occluded from interaction with solvent water, and ion-paired to the surface alkyl ammonium side chain of residue K12. The neutral imidazole side chain of H95 interacts with the carbonyl oxygen of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate
-
-
?
additional information
?
-
the effect of bound phosphite dianion on the activation barrier is small, in comparison to the much larger intrinsic phosphodianion and phosphite dianion binding energy utilized to stabilize the transition states for TIM-catalyzed deprotonation of glyceraldehyde-3-phosphate and glyceraldehyde-phosphite dianion complex, respectively
-
-
?