5.1.3.20: ADP-glyceromanno-heptose 6-epimerase
This is an abbreviated version!
For detailed information about ADP-glyceromanno-heptose 6-epimerase, go to the full flat file.
Word Map on EC 5.1.3.20
-
5.1.3.20
-
lipopolysaccharide
-
nadp+
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lps
-
nonstereospecific
-
hydride
-
udp-galactose
-
haemophilus
-
4-epimerase
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coleman
-
heptosyltransferase
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dismutation
-
epimerization
-
novobiocin
-
non-pathogenic
-
epimeric
-
biofilm-forming
- 5.1.3.20
- lipopolysaccharide
- nadp+
- lps
-
nonstereospecific
-
hydride
- udp-galactose
-
haemophilus
-
4-epimerase
-
coleman
-
heptosyltransferase
-
dismutation
-
epimerization
- novobiocin
-
non-pathogenic
-
epimeric
-
biofilm-forming
Reaction
Synonyms
Adenosine diphosphoglyceromannoheptose 6-epimerase, ADP-glycero-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-L,D-hep 6-epimerase, ADP-L-glycero-D-manno-heptose 6-epimerase, ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-D-manno-heptose-epimerase, Aquifex aelicis gene rfaD, ADP-L-glycero-D-mannoheptose 6-epimerase, ADP-L-glycero-D-mannoheptose 6-epimerase (Neisseria gonorrhoeae gene gme), ADP-L-glycero-D-mannoheptose-6-epimerase, ADP-L-glycero-D-mannoheptose-6-epimerase (Escherichia coli strain K-12 substrain MG1655 clone EC19-98 gene rfaD), AGME, Epimerase, adenosine diphosphoglyceromannoheptose 6-, Epimerase, adenosine diphosphoglyceromannoheptose 6- (Escherichia coli clone pCG50 reduced), Epimerase, adenosine diphosphoglyceromannoheptose 6- (Neisseria gonorrhoeae gene lis-6), Genbank AE000440-derived protein GI 1790049, GenBank AE000684-derived protein GI 2983012, GmhD, hldD, HP0859, RfaD
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Reference on EC 5.1.3.20 - ADP-glyceromanno-heptose 6-epimerase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pegues, J.C.; Chen, L.; Gordon, A.W.; Ding, L.; Coleman, W.G.
Cloning, expression, and characterization of the Escherichia coli K-12 rfaD gene
J. Bacteriol.
172
4652-4660
1990
Escherichia coli
Coleman, W.G.
The rfaD gene codes for ADP-L-glycero-D-mannoheptose-6-epimerase
J. Biol. Chem.
258
1985-1990
1983
Escherichia coli
Ding, L.; Seto, B.L.; Ahmed, S.A.; Coleman, W.G.
Purification and properties of the Escherichia coli K-12 NAD-dependent nucleotide diphosphosulfate epimerase, ADP-L-glycero-D-mannoheptose 6-epimerase
J. Biol. Chem.
269
24384-24390
1994
Escherichia coli
Drazek, E.S.; Stein, D.C.; Deal, C.D.
A mutation in the Neisseria gonorrhoeae rfaD homolog results in altered lipooligosaccharide expression
J. Bacteriol.
177
2321-2327
1995
Neisseria gonorrhoeae
Nichols, W.A.; Gibson, B.W.; Melaugh, W.; Lee, N.G.; Sunshine, M.; Apicella, M.A.
Identification of the ADP-L-glycero-D-manno-heptose-6-epimerase (rfaD) and heptosyltransferase II (rfaF) biosynthesis genes from nontypeable Haemophilus influenzae 2019
Infect. Immun.
65
1377-1386
1997
Haemophilus influenzae, Haemophilus influenzae 2019
Sirisena, D.M.; MacLachlan, P.R.; Liu, S.L.; Hessel, A.; Sanderson, K.E.
Molecular analysis of the rfaD gene, for heptose synthesis, and the rfaF gene, for heptose transfer, in lipopolysaccharide synthesis in Salmonella typhimurium
J. Bacteriol.
176
2379-2385
1994
Salmonella enterica subsp. enterica serovar Typhimurium
Ding, L.; Zhang, Y.; Deacon, A.M.; Ealick, S.E.; Ni, Y.; Sun, P.; Coleman, W.G., Jr.
Crystallization and preliminary X-ray diffraction studies of the lipopolysaccharide core biosynthetic enzyme ADP-L-glycero-D-mannoheptose 6-epimerase from Escherichia coli K-12
Acta Crystallogr. Sect. D
55
685-688
1999
Escherichia coli
Ni, Y.; McPhie, P.; Deacon, A.; Ealick, S.; Coleman, W.G., Jr.
Evidence that NADP+ is the physiological cofactor of ADP-L-glycero-D-mannoheptose 6-epimerase
J. Biol. Chem.
276
27329-27334
2001
Escherichia coli (P67910)
Deacon, A.M.; Ni, Y.S.; Coleman, W.G., Jr.; Ealick, S.E.
The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist
Structure
8
453-462
2000
Escherichia coli
Morrison, J.P.; Read, J.A.; Coleman, W.G., Jr.; Tanner, M.E.
Dismutase activity of ADP-L-glycero-D-manno-heptose 6-epimerase: evidence for a direct oxidation/reduction mechanism
Biochemistry
44
5907-5915
2005
Escherichia coli
Read, J.A.; Ahmed, R.A.; Morrison, J.P.; Coleman, W.G., Jr.; Tanner, M.E.
The mechanism of the reaction catalyzed by ADP-beta-L-glycero-D-manno-heptose 6-epimerase
J. Am. Chem. Soc.
126
8878-8879
2004
Escherichia coli
Read, J.A.; Ahmed, R.A.; Tanner, M.E.
Efficient chemoenzymatic synthesis of ADP-D-glycero-beta-D-manno-heptose and a mechanistic study of ADP-L-glycero-D-manno-heptose 6-epimerase
Org. Lett.
7
2457-2460
2005
Escherichia coli
Morrison, J.P.; Tanner, M.E.
A Two-Base Mechanism for Escherichia coli ADP-L-glycero-D-manno-Heptose 6-Epimerase
Biochemistry
46
3916-3924
2007
Escherichia coli
Mayer, A.; Tanner, M.E.
Intermediate release by ADP-L-glycero-D-manno-heptose 6-epimerase
Biochemistry
46
6149-6155
2007
Escherichia coli
Kim, H.; Lee, M.; Chun, S.; Park, S.; Lee, K.
Role of NtrC in biofilm formation via controlling expression of the gene encoding an ADP-glycero-manno-heptose-6-epimerase in the pathogenic bacterium, Vibrio vulnificus
Mol. Microbiol.
63
559-574
2007
Vibrio vulnificus
Kowatz, T.; Morrison, J.P.; Tanner, M.E.; Naismith, J.H.
The crystal structure of the Y140F mutant of ADP-L-glycero-D-manno-heptose 6-epimerase bound to ADP-beta-D-mannose suggests a one base mechanism
Protein Sci.
19
1337-1343
2010
Escherichia coli (P67910)
Kim, M.; Lim, A.; Yang, S.; Park, J.; Lee, D.; Shin, D.
Structure and in silico substrate-binding mode of ADP-L-glycero-D-manno-heptose 6-epimerase from Burkholderia thailandensis
Acta Crystallogr. Sect. D
69
658-668
2013
Burkholderia thailandensis (Q2SY18), Burkholderia thailandensis, Burkholderia thailandensis E444 (Q2SY18)
Shaik, M.M.; Zanotti, G.; Cendron, L.
The crystal structure of ADP-L-glycero-D-manno-heptose-6-epimerase (HP0859) from Helicobacter pylori
Biochim. Biophys. Acta
1814
1641-1647
2011
Helicobacter pylori (B5Z7L9), Helicobacter pylori, Helicobacter pylori G27 (B5Z7L9)
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