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5.1.3.19: chondroitin-glucuronate 5-epimerase

This is an abbreviated version!
For detailed information about chondroitin-glucuronate 5-epimerase, go to the full flat file.

Word Map on EC 5.1.3.19

Reaction

chondroitin D-glucuronate
=
dermatan L-iduronate

Synonyms

Chondroitin D-glucuronosyl 5-epimerase, chondroitin-glucuronate C5-epimerase, dermatan sulfate epimerase, dermatan sulfate epimerase 1, dermatan sulfate epimerase 2, dermatan sulfate epimerase like, dermatan sulfate epimerase-2, dermatan sulfate epimerase-like a, dermatan sulfate epimerase-like b, Dermatan-sulfate 5-epimerase, DS epimerase 1, DS epimerase 2, DS-epi1, DS-epi2, DS-epimerase 1, DSE, DSEL, dsela, dselb, Epimerase, chondroitin glucuronate 5-, Polyglucuronate 5-epimerase, SART2

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.3 Acting on carbohydrates and derivatives
                5.1.3.19 chondroitin-glucuronate 5-epimerase

Reference

Reference on EC 5.1.3.19 - chondroitin-glucuronate 5-epimerase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Campbell, P.; Feingold, D.S.; Jensen, J.W.; Malmström, A.; Roden, L.
New assay for uronosyl 5-epimerase
Anal. Biochem.
131
146-152
1983
Homo sapiens
Manually annotated by BRENDA team
Malmström, A.
Biosynthesis of dermatan sulfate. II. Substrate specificity of the C-5 uronosyl epimerase
J. Biol. Chem.
259
161-165
1984
Homo sapiens
Manually annotated by BRENDA team
Malmström, A.; Aberg, L.
Biosynthesis of dermatan sulphate. Assay and properties of the uronosyl C-5 epimerase
Biochem. J.
201
489-493
1982
Homo sapiens
Manually annotated by BRENDA team
Malmström, A.; Frasson, L.A.; Höök, M.; Lindahl, U.
Biosynthesis of dermatan sulfate. I. Formation of L-iduronic acid residues
J. Biol. Chem.
250
3419-3425
1975
Homo sapiens
Manually annotated by BRENDA team
Cöster, L.; Hernnäs, J.; Malmström, A.
Biosynthesis of dermatan sulphate proteoglycans. The effect of beta-D-xyloside addition on the polymer-modification process in fibroblast cultures
Biochem. J.
276
533-539
1991
Homo sapiens
Manually annotated by BRENDA team
Hannesson, H.H.; Hagner-McWhirter, A.; Tiedemann, K.; Lindahl, U.; Malmström, A.
Biosynthesis of dermatan sulphate. Defructosylated Escherichia coli K4 capsular polysaccharide as a substrate for the D-glucuronyl C-5 epimerase, and an indication of a two-base reaction mechanism
Biochem. J.
313
589-596
1996
Homo sapiens
Manually annotated by BRENDA team
Tiedemann, K.; Olander, B.; Eklund, E.; Todorova, L.; Bengtsson, M.; Maccarana, M.; Westergren-Thorsson, G.; Malmstroem, A.
Regulation of the chondroitin/dermatan fine structure by transforming growth factor-b1 through effects on polymer-modifying enzymes
Glycobiology
15
1277-1285
2005
Homo sapiens
Manually annotated by BRENDA team
Maccarana, M.; Olander, B.; Malmstroem, J.; Tiedemann, K.; Aebersold, R.; Lindahl, U.; Li, J.P.; Malmstroem, A.
Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2
J. Biol. Chem.
281
11560-11568
2006
Bos taurus
Manually annotated by BRENDA team
Pacheco, B.; Maccarana, M.; Goodlett, D.R.; Malmstroem, A.; Malmstroem, L.
Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function
J. Biol. Chem.
284
1741-1747
2009
Homo sapiens (Q9UL01)
Manually annotated by BRENDA team
Pacheco, B.; Malmstroem, A.; Maccarana, M.
Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate
J. Biol. Chem.
284
9788-9795
2009
Homo sapiens
Manually annotated by BRENDA team
Maccarana, M.; Kalamajski, S.; Kongsgaard, M.; Magnusson, S.P.; Oldberg, A.; Malmstroem, A.
Dermatan sulfate epimerase 1-deficient mice have reduced content and changed distribution of iduronic acids in dermatan sulfate and an altered collagen structure in skin
Mol. Cell. Biol.
29
5517-5528
2009
Mus musculus
Manually annotated by BRENDA team
Akatsu, C.; Mizumoto, S.; Kaneiwa, T.; Maccarana, M.; Malmstroem, A.; Yamada, S.; Sugahara, K.
Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain
Glycobiology
21
565-574
2011
Mus musculus (Q0VBN2), Mus musculus (Q8BLI4), Mus musculus
Manually annotated by BRENDA team
Mueller, T.; Mizumoto, S.; Suresh, I.; Komatsu, Y.; Vodopiutz, J.; Dundar, M.; Straub, V.; Lingenhel, A.; Melmer, A.; Lechner, S.; Zschocke, J.; Sugahara, K.; Janecke, A.R.
Loss of dermatan sulfate epimerase (DSE) function results in musculocontractural Ehlers-Danlos syndrome
Hum. Mol. Genet.
22
3761-3772
2013
Homo sapiens (Q8IZU8), Homo sapiens (Q9UL01), Homo sapiens
Manually annotated by BRENDA team
Tykesson, E.; Mao, Y.; Maccarana, M.; Pu, Y.; Gao, J.; Lin, C.; Zaia, J.; Westergren-Thorsson, G.; Ellervik, U.; Malmstroem, L.; Malmstroem, A.
Deciphering the mode of action of the processive polysaccharide modifying enzyme dermatan sulfate epimerase 1 by hydrogen-deuterium exchange mass spectrometry
Chem. Sci.
7
1447-1456
2016
Homo sapiens
Manually annotated by BRENDA team
Habicher, J.; Haitina, T.; Eriksson, I.; Holmborn, K.; Dierker, T.; Ahlberg, P.E.; Ledin, J.
Chondroitin / dermatan sulfate modification enzymes in zebrafish development
PLoS ONE
10
e0121957
2015
Danio rerio, Danio rerio (B8A5U5), Danio rerio (Q5RGL8)
Manually annotated by BRENDA team
Gouignard, N.; Schoen, T.; Holmgren, C.; Strate, I.; Tasoez, E.; Wetzel, F.; Maccarana, M.; Pera, E.
Gene expression of the two developmentally regulated dermatan sulfate epimerases in the Xenopus embryo
PLoS ONE
13
e0191751
2018
Xenopus laevis (A0A166W7U1), Xenopus laevis (B1H189)
Manually annotated by BRENDA team