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5.1.3.19: chondroitin-glucuronate 5-epimerase

This is an abbreviated version!
For detailed information about chondroitin-glucuronate 5-epimerase, go to the full flat file.

Word Map on EC 5.1.3.19

Reaction

chondroitin D-glucuronate
=
dermatan L-iduronate

Synonyms

Chondroitin D-glucuronosyl 5-epimerase, chondroitin-glucuronate C5-epimerase, dermatan sulfate epimerase, dermatan sulfate epimerase 1, dermatan sulfate epimerase 2, dermatan sulfate epimerase like, dermatan sulfate epimerase-2, dermatan sulfate epimerase-like a, dermatan sulfate epimerase-like b, Dermatan-sulfate 5-epimerase, DS epimerase 1, DS epimerase 2, DS-epi1, DS-epi2, DS-epimerase 1, DSE, DSEL, dsela, dselb, Epimerase, chondroitin glucuronate 5-, Polyglucuronate 5-epimerase, SART2

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.3 Acting on carbohydrates and derivatives
                5.1.3.19 chondroitin-glucuronate 5-epimerase

Expression

Expression on EC 5.1.3.19 - chondroitin-glucuronate 5-epimerase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
generation of DS-epi1-null mice, the mutant mice show alterations in the chondroitin/dermatan polysaccharide chains. The numbers of long blocks of adjacent iduronic acids are greatly decreased in skin decorin and biglycan chondroitin/dermatan sulfate, along with a parallel decrease in iduronic-2-O-sulfated-galactosamine-4-O-sulfated structures. Both iduronic acid blocks and iduronic acids surrounded by glucuronic acids are also decreased in versican-derived chains. DS-epi1-deficient mice are smaller than their wild-type littermates but otherwise have no gross macroscopic alterations, DS-epi1-null fibrils have a larger diameter than the wild-type fibrils, phenotypes, overview
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