5.1.3.19: chondroitin-glucuronate 5-epimerase
This is an abbreviated version!
For detailed information about chondroitin-glucuronate 5-epimerase, go to the full flat file.
Word Map on EC 5.1.3.19
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5.1.3.19
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iduronic
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glycosaminoglycans
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proteoglycans
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epimerization
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decorin
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d-glucuronic
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ehlers-danlos
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musculocontractural
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chst14
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4-o-sulfotransferase
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mceds
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idoa
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4-o-sulfated
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analysis
- 5.1.3.19
-
iduronic
- glycosaminoglycans
- proteoglycans
-
epimerization
- decorin
-
d-glucuronic
- ehlers-danlos
-
musculocontractural
- chst14
-
4-o-sulfotransferase
-
mceds
-
idoa
-
4-o-sulfated
- analysis
Reaction
Synonyms
Chondroitin D-glucuronosyl 5-epimerase, chondroitin-glucuronate C5-epimerase, dermatan sulfate epimerase, dermatan sulfate epimerase 1, dermatan sulfate epimerase 2, dermatan sulfate epimerase like, dermatan sulfate epimerase-2, dermatan sulfate epimerase-like a, dermatan sulfate epimerase-like b, Dermatan-sulfate 5-epimerase, DS epimerase 1, DS epimerase 2, DS-epi1, DS-epi2, DS-epimerase 1, DSE, DSEL, dsela, dselb, Epimerase, chondroitin glucuronate 5-, Polyglucuronate 5-epimerase, SART2
ECTree
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Engineering
Engineering on EC 5.1.3.19 - chondroitin-glucuronate 5-epimerase
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H205A
site-directed mutagenesis of the catalytic site residue, the mutant shows complete loss of epimerase activity
H450A
site-directed mutagenesis of the catalytic site residue, the mutant shows complete loss of epimerase activity
N183S
site-directed mutagenesis of an N-glycosylation site in DS-epi1 altering reaction kinetics
N336S
site-directed mutagenesis of an N-glycosylation site in DS-epi1 altering reaction kinetics and reducing the activity 13fold
N642S
site-directed mutagenesis of an N-glycosylation site in DS-epi1 altering reaction kinetics
N648S
site-directed mutagenesis of an N-glycosylation site in DS-epi1 altering reaction kinetics and reducing the activity 43fold
S268L
a naturally occuring homozygous DSE mutation c.803C>T in a patient with musculocontractural type of Ehlers-Danlos syndrome, MCEDS. The mutant enzymes shows a loss of activity towards partially desulfated dermatan sulfate, patient-derived fibroblasts also show a significant reduction in epimerase activity
Y261A
site-directed mutagenesis of the catalytic site residue, the mutant shows complete loss of epimerase activity
additional information
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siRNA gene silencing of DS-epi2 and DS-epi1 in lung HFL-1 fibroblasts