5.1.3.18: GDP-mannose 3,5-epimerase

This is an abbreviated version!
For detailed information about GDP-mannose 3,5-epimerase, go to the full flat file.

Reaction

Synonyms

Epimerase, guanosine diphosphomannose, GDP-D-mannose 3'',5''-epimerase, GDP-D-mannose 3',5'-epimerase, GDP-D-mannose 3,5-epimerase, GDP-D-mannose-3',5'-epimerase, GDP-D-mannose:GDP-L-galactose epimerase, GDP-mannose 3",5"-epimerase, GDP-mannose 3',5'-epimerase, GDP-mannose-3',5'-epimerase, GME, GME1, GME2, OsGME

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.3 Acting on carbohydrates and derivatives

                5.1.3.18 GDP-mannose 3,5-epimerase

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Results	in table
1	Activating Compound
64	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
4	Expression
10	General Information
1	IC50 Value
10	Inhibitors
9	KM Value [mM]
2	Localization
6	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
19	Organism
11	Pathway
8	PDB ID
4	pH Optimum
2	pH Range
2	pI Value
1	Protein Variants
3	Purification (Commentary)
5	Reaction
1	Reaction Type
19	Reference
19	Source Tissue
2	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
2	Subunits
24	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
5	Turnover Number [1/s]

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Engineering on EC 5.1.3.18 - GDP-mannose 3,5-epimerase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Solanum lycopersicum

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construction of transgenic tomato lines RNAi-silenced for GME, RNAi silencing of GME in tomato effectively reduces ascorbate content in the plant, leading to ROS accumulation, leaf bleaching and developmental defects. Transgenic plants display strong alterations in cell-wall composition, with a considerable impact on plant and fruit mechanical properties, GME-silenced lines have increased fragility, phenotype, overview

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