5.1.3.17: heparosan-N-sulfate-glucuronate 5-epimerase

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For detailed information about heparosan-N-sulfate-glucuronate 5-epimerase, go to the full flat file.

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Synonyms

C5 uronosyl epimerase, C5-epi, C5-epimerase, D-Glucuronyl C-5 epimerase, D-glucuronyl C5-epimerase, Epimerase, polyglucuronate, Glce, GlceA, GlceB, glucuronosyl C-5 epimerase, glucuronyl C5-epimerase, heparan sulfate C-5 epimerase, Heparan sulfate C5-epimerase, Heparosan N-sulfate D-glucuronosyl 5-epimerase, heparosan-glucuronate 5-epimerase, Heparosan-N-sulfate-D-glucuronosyl-5-epimerase, HG-5epi, HNSG-5epi, HS C5-epimerase, HS glucuronyl C5-epimerase, Hsepi, RED-C5-epimerase

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.3 Acting on carbohydrates and derivatives

                5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase

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Results	in table
1524	AA Sequence
6	Application
1	CAS Registry Number
12	Cloned(Commentary)
1	Crystallization (Commentary)
42	Disease/ Diagnostics
2	Expression
21	General Information
7	Inhibitors
4	KM Value [mM]
2	Localization
2	Metals/Ions
7	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
244	Organism
3	Pathway
9	PDB ID
5	pH Optimum
2	pH Range
1	Posttranslational Modification
28	Protein Variants
7	Purification (Commentary)
2	Reaction
1	Reaction Type
84	Reference
46	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
43	Substrates and Products (Substrate)
9	Subunits
99	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 5.1.3.17 - heparosan-N-sulfate-glucuronate 5-epimerase

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SYSTEMATIC NAME

IUBMB Comments

poly[(1->4)-beta-D-glucuronosyl-(1->4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase

The enzyme acts on D-glucosyluronate residues in N-sulfated heparosan polymers, converting them to L-iduronate, thus modifying the polymer to heparan-N-sulfate. The enzyme requires that at least the N-acetylglucosamine residue linked to C-4 of the substrate has been deacetylated and N-sulfated, and activity is highest with fully N-sulfated substrate. It does not act on glucuronate residues that are O-sulfated or are adjacent to N-acetylglucosamine residues that are O-sulfated at the 6 position. Thus the epimerization from D-glucuronate to L-iduronate occurs after N-sulfation of glucosamine residues but before O-sulfation. Not identical with EC 5.1.3.19 chondroitin-glucuronate 5-epimerase or with EC 5.1.3.36, heparosan-glucuronate 5-epimerase.