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5.1.3.17: heparosan-N-sulfate-glucuronate 5-epimerase

This is an abbreviated version!
For detailed information about heparosan-N-sulfate-glucuronate 5-epimerase, go to the full flat file.

Word Map on EC 5.1.3.17

Reaction

heparosan-N-sulfate D-glucuronate
=
heparosan-N-sulfate L-iduronate

Synonyms

C5 uronosyl epimerase, C5-epi, C5-epimerase, D-Glucuronyl C-5 epimerase, D-glucuronyl C5-epimerase, Epimerase, polyglucuronate, Glce, GlceA, GlceB, glucuronosyl C-5 epimerase, glucuronyl C5-epimerase, heparan sulfate C-5 epimerase, Heparan sulfate C5-epimerase, Heparosan N-sulfate D-glucuronosyl 5-epimerase, heparosan-glucuronate 5-epimerase, Heparosan-N-sulfate-D-glucuronosyl-5-epimerase, HG-5epi, HNSG-5epi, HS C5-epimerase, HS glucuronyl C5-epimerase, Hsepi, RED-C5-epimerase

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.3 Acting on carbohydrates and derivatives
                5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase

Inhibitors

Inhibitors on EC 5.1.3.17 - heparosan-N-sulfate-glucuronate 5-epimerase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
heparin hexasaccharide
mechanism of product inhibition of the enzyme: 2-O- and 6-O-sulfation of heparan sulfate keeps the C5 carbon of L-iduronic acid away from the active-site tyrosine residues, binding structure, detailed overview
-
KCl
-
stimulates, maximal effect at 0.1 M, inhibition at higher concentrations
n-octyl-beta-D-glucoside
-
NaCl
-
stimulates, maximal effect at 0.05 M, inhibition at higher concentrations
sodium deoxycholate
complete inhibition at 0.1%
additional information
-