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5.1.3.17: heparosan-N-sulfate-glucuronate 5-epimerase

This is an abbreviated version!
For detailed information about heparosan-N-sulfate-glucuronate 5-epimerase, go to the full flat file.

Word Map on EC 5.1.3.17

Reaction

heparosan-N-sulfate D-glucuronate
=
heparosan-N-sulfate L-iduronate

Synonyms

C5 uronosyl epimerase, C5-epi, C5-epimerase, D-Glucuronyl C-5 epimerase, D-glucuronyl C5-epimerase, Epimerase, polyglucuronate, Glce, GlceA, GlceB, glucuronosyl C-5 epimerase, glucuronyl C5-epimerase, heparan sulfate C-5 epimerase, Heparan sulfate C5-epimerase, Heparosan N-sulfate D-glucuronosyl 5-epimerase, heparosan-glucuronate 5-epimerase, Heparosan-N-sulfate-D-glucuronosyl-5-epimerase, HG-5epi, HNSG-5epi, HS C5-epimerase, HS glucuronyl C5-epimerase, Hsepi, RED-C5-epimerase

ECTree

     5 Isomerases
         5.1 Racemases and epimerases
             5.1.3 Acting on carbohydrates and derivatives
                5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase

Engineering

Engineering on EC 5.1.3.17 - heparosan-N-sulfate-glucuronate 5-epimerase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H584A
site-directed mutagenesis, the mutant shows 80% reduced activity compared to wild-type
N585A
site-directed mutagenesis, the mutant shows 90% reduced activity compared to wild-type
R154A
site-directed mutagenesis, the mutant shows 60% reduced activity compared to wild-type
R156A
site-directed mutagenesis, the mutant shows over 90% reduced activity compared to wild-type
R396A
site-directed mutagenesis, the mutant shows 90% reduced activity compared to wild-type
R531A
site-directed mutagenesis, the mutant shows about 90% reduced activity compared to wild-type
R543A
site-directed mutagenesis, the mutant shows over 90% reduced activity compared to wild-type
Y149F
site-directed mutagenesis, the mutant shows over 90% reduced activity compared to wild-type
Y177F
site-directed mutagenesis, the mutant shows 40% reduced activity compared to wild-type
Y179F
site-directed mutagenesis, the mutant shows slightly reduced activity compared to wild-type
Y468A
site-directed mutagenesis, the mutant shows over 90% reduced activity compared to wild-type
Y468F
site-directed mutagenesis, the mutant shows 75% reduced activity compared to wild-type
Y482F
site-directed mutagenesis, the mutant shows 20% reduced activity compared to wild-type
Y528A
site-directed mutagenesis, the mutant shows over 90% reduced activity compared to wild-type
Y528F
site-directed mutagenesis, the mutant shows over 90% reduced activity compared to wild-type
Y546A
site-directed mutagenesis, the mutant shows over 90% reduced activity compared to wild-type
Y546F
site-directed mutagenesis, the mutant shows over 90% reduced activity compared to wild-type
Y146A
-
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme
Y162A
-
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme
Y168A
-
site-directed mutagenesis, inactive mutant
Y210A
-
site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme
Y222A
-
site-directed mutagenesis, inactive mutant
additional information