5.1.3.17: heparosan-N-sulfate-glucuronate 5-epimerase

This is an abbreviated version!
For detailed information about heparosan-N-sulfate-glucuronate 5-epimerase, go to the full flat file.

Word Map on EC 5.1.3.17

5.1.3.17

l-iduronic

d-glucuronic

epimerization

proteoglycans

idoa

glycosaminoglycans

glca

n-sulfated

2-o-sulfotransferase

hexuronic

hspgs

2-o-sulfation

mastocytoma

mannuronan

lindahl

o-desulfated

medicine

diagnostics

analysis

synthesis

Reaction

Synonyms

C5 uronosyl epimerase, C5-epi, C5-epimerase, D-Glucuronyl C-5 epimerase, D-glucuronyl C5-epimerase, Epimerase, polyglucuronate, Glce, GlceA, GlceB, glucuronosyl C-5 epimerase, glucuronyl C5-epimerase, heparan sulfate C-5 epimerase, Heparan sulfate C5-epimerase, Heparosan N-sulfate D-glucuronosyl 5-epimerase, heparosan-glucuronate 5-epimerase, Heparosan-N-sulfate-D-glucuronosyl-5-epimerase, HG-5epi, HNSG-5epi, HS C5-epimerase, HS glucuronyl C5-epimerase, Hsepi, RED-C5-epimerase

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.3 Acting on carbohydrates and derivatives

5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase

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Results	in table
1524	AA Sequence
6	Application
1	CAS Registry Number
12	Cloned(Commentary)
1	Crystallization (Commentary)
42	Disease/ Diagnostics
2	Expression
21	General Information
7	Inhibitors
4	KM Value [mM]
2	Localization
2	Metals/Ions
7	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
244	Organism
3	Pathway
9	PDB ID
5	pH Optimum
2	pH Range
1	Posttranslational Modification
28	Protein Variants
7	Purification (Commentary)
2	Reaction
1	Reaction Type
84	Reference
46	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
43	Substrates and Products (Substrate)
9	Subunits
99	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Disease

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Disease on EC 5.1.3.17 - heparosan-N-sulfate-glucuronate 5-epimerase

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Breast Neoplasms

Antiproliferative effect of D-glucuronyl C5-epimerase in human breast cancer cells.

20723247

Decreased expression of human D-glucuronyl C5-epimerase in breast cancer.

17985344

The TCF4/?-catenin pathway and chromatin structure cooperate to regulate D-glucuronyl C5-epimerase expression in breast cancer.

22805760

Carcinogenesis

D-glucuronyl C5-epimerase cell type specifically affects angiogenesis pathway in different prostate cancer cells.

24264315

GLCE rs3865014 (Val597Ile) polymorphism is associated with breast cancer susceptibility and triple-negative breast cancer in Siberian population.

28734894

Lung Neoplasms

D-glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo.

21654676

Mastocytoma

Biosynthesis of heparin. Partial purification of the uronosyl C-5 epimerase.

6768743

Biosynthesis of heparin. Substrate specificity of heparosan N-sulfate D-glucuronosyl 5-epimerase.

6420398

Biosynthesis of heparin/heparan sulfate: kinetic studies of the glucuronyl C5-epimerase with N-sulfated derivatives of the Escherichia coli K5 capsular polysaccharide as substrates.

10642607

Neoplasms

D-glucuronyl C5-epimerase cell type specifically affects angiogenesis pathway in different prostate cancer cells.

24264315

D-glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo.

21654676

miRNA-218 contributes to the regulation of D-glucuronyl C5-epimerase expression in normal and tumor breast tissues.

22968430

Prostatic Neoplasms

D-glucuronyl C5-epimerase cell type specifically affects angiogenesis pathway in different prostate cancer cells.

24264315

Heterogeneity of d-glucuronyl C5-epimerase expression and epigenetic regulation in prostate cancer.

24403231

Pulmonary Atelectasis

Glucuronyl C5-epimerase is crucial for epithelial cell maturation during embryonic lung development.

32651954