5.1.1.4: proline racemase
This is an abbreviated version!
For detailed information about proline racemase, go to the full flat file.
Word Map on EC 5.1.1.4
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5.1.1.4
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trypanosoma
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cruzi
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d-proline
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chagas
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oversaturated
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diaminopimelate
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2-epimerase
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pyrrole-2-carboxylic
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stickland
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medicine
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abeles
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trypanosomosis
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stereoinversion
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pracs
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lumazine
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drug development
- 5.1.1.4
- trypanosoma
- cruzi
- d-proline
- chagas
-
oversaturated
- diaminopimelate
-
2-epimerase
-
pyrrole-2-carboxylic
-
stickland
- medicine
-
abeles
-
trypanosomosis
-
stereoinversion
-
pracs
- lumazine
- drug development
Reaction
Synonyms
CdPRAC, CdProR, FaProR, HjProR, PA45-A, PA45-B, PRAC, PRAC1, PrdF, proline racemase, proline racemase A, proline racemase B, proline racemase/hydroxyproline epimerase, ProR, ProR/HypE, Racemase, proline, TcPA45, TcPRAC, TcPRACA, TcPRACB, Tgr.146.1080, TryPRAC, TvHYP1, TvPRAC
ECTree
5.1.1.4 proline racemaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 5.1.1.4 - proline racemase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(E)-4-oxopent-2-enoic acid
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an irreversible strong competitive inhibitor, which hampers Trypanosoma cruzi intracellular differentiation and fate in mammalian host cells
(E)-5-bromo-4-oxopent-2-enoic acid
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an irreversible strong competitive inhibitor, which hampers Trypanosoma cruzi intracellular differentiation and fate in mammalian host cells
7-azabicyclo[2.2.1]heptan-7-ium-1-carboxylate
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a weak inhibitor of proline racemase, 29% inhibition at 142.5 mM
tetrahydro-1H-pyrrolizine-7a(5H)-carboxylate
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a bicyclic substrate-product analogue and noncompetitive inhibitor of proline racemase
pyrrole-2-carboxylic acid
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inhibitor significantly affects parasite infection of Vero cells in vitro, inhibitor also hampers Trypanosoma cruzi intracellular differentiation, inhibitor reduces host cell invasion in Vero cells by Trypanososma cruzi in a dose-dependent manner, pre-treatment of the parasites with 1 mM of inhibitor does not lead to changes in their morphology and motility, but results in an up to 54% reduction in the percentage of parasitized cells and about 30% less parasites per cell when cultures are counted at day 4 after infection
additional information
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substrate-product analogue inhibitors of racemases may only be effective when the active site is capacious and/or plastic, or when the inhibitor is sufficiently flexible
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additional information
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synthesized soluble pyrazole derivatives prove to be weak or inactive TcPRAC inhibitors
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