5.1.1.14: nocardicin A epimerase

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For detailed information about nocardicin A epimerase, go to the full flat file.

Reaction

Synonyms

Epimerase, isonocardicin A, nocardicin C-9'epimerase, NocJ

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.1 Acting on amino acids and derivatives

                5.1.1.14 nocardicin A epimerase

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4	Pathway
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Systematic Name

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Systematic Name on EC 5.1.1.14 - nocardicin A epimerase

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SYSTEMATIC NAME

IUBMB Comments

nocardicin-C epimerase

Requires pyridoxal 5'-phosphate. The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the monolactam antibiotic nocardicin A. It catalyses the epimerization of the amino group at position 9' from (S)- configuration to (R)-. The enzyme can act on both isonocardicin A and isonocardicin C, but the in vivo substrate appears to be the latter [3].