5.1.1.11: phenylalanine racemase (ATP-hydrolysing)
This is an abbreviated version!
For detailed information about phenylalanine racemase (ATP-hydrolysing), go to the full flat file.
Word Map on EC 5.1.1.11
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5.1.1.11
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brevis
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racemization
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nonribosomal
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adenylate
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thioester
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three-domain
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synthetases
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decapeptide
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aminoacyl
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epimerization
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nagano
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triphosphate-dependent
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single-turnover
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non-producing
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diester
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d-phe
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equilibrate
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thiolation
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4'-phosphopantetheine
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phenylalanyl
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synthesis
- 5.1.1.11
- brevis
-
racemization
-
nonribosomal
- adenylate
- thioester
-
three-domain
- synthetases
-
decapeptide
-
aminoacyl
-
epimerization
-
nagano
-
triphosphate-dependent
-
single-turnover
-
non-producing
-
diester
- d-phe
-
equilibrate
-
thiolation
- 4'-phosphopantetheine
-
phenylalanyl
- synthesis
Reaction
Synonyms
Gramicidin S synthetase I, GrsA, GS I, PheATE, Phenylalanine racemase, Phenylalanine racemase (adenosine triphosphate-hydrolyzing), Phenylalanine racemase (ATP-hydrolyzing), Racemase, phenylalanine (adenosine triphosphate-hydrolyzing)
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5.1.1.11 phenylalanine racemase (ATP-hydrolysing)Advanced search results
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results (Substrates Products
Substrates Products on EC 5.1.1.11 - phenylalanine racemase (ATP-hydrolysing)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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the enzyme catalyzes Phe racemization and activation. Catalyzes ATP-AMP exchange reaction, L-Phe dependent ATP-AMP exchange reaction
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?
ATP + L-Phe + H2O
AMP + diphosphate + D-Phe
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equilibrium ratio of L-Phe to D-Phe is 3:7
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?
ATP + L-phenylalanine + H2O
?
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phenylalanine racemase, i.e. gramicidin-S synthetase 1, activates and transfers D-Phe to the heavy enzyme, gramicidin S-synthetase 2, which activates the other constituent amino acids on the thioester template
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-
?
ATP + L-phenylalanine + H2O
?
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phenylalanine racemase, the light component of gramicidin S synthetase, racemizes Phe and activates it to the aminoacyl adenylate and in a second step to the thioester
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-
?
ATP + L-phenylalanine + H2O
AMP + diphosphate + D-phenylalanine
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there are three activated intermediates: L-phenylalanyl-adenosine-5'-monophosphate diester, L-Phe-S-4'-phosphopantetheine and D-Phe-S-4'-phosphopantetheine-acyl enzyme
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?
ATP + L-phenylalanine + H2O
AMP + diphosphate + D-phenylalanine
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the three-domain initiation module PheATE of gramicidin S synthetase catalyzes the activation, thiolation and epimerization of L-phenylalanine, the first amino acid incorporated into the decapeptide antibiotic gramicidin S
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?
