4.4.1.5: lactoylglutathione lyase

This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.

Word Map on EC 4.4.1.5

4.4.1.5

glycation

detoxify

gsh

dicarbonyls

erythrocyte

d-lactate

adduct

dismutase

endproducts

rage

s-transferase

mellitus

methylglyoxal-induced

glyoxalases

byproduct

hyperglycemia

glutathione-dependent

phosphoglucomutase

metalloenzyme

hemithioacetal

mg-induced

hla-a

aldose

3-deoxyglucosone

enediolate

d-lactic

pentosidine

cyclopentyl

mdhar

haptoglobin

aminoguanidine

diesters

monodehydroascorbate

6-phosphogluconate

anti-glycation

dehydroascorbate

anxiety-like

gsh-dependent

pyridoxamine

analysis

trypanothione

medicine

drug development

Reaction

Synonyms

aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA

ECTree

4 Lyases

4.4 Carbon-sulfur lyases

4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

4.4.1.5 lactoylglutathione lyase

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Results	in table
43	Activating Compound
16665	AA Sequence
23	Application
1	CAS Registry Number
55	Cloned(Commentary)
35	Cofactor
15	Crystallization (Commentary)
1045	Disease/ Diagnostics
25	Expression
41	General Information
1	General Stability
42	IC50 Value
326	Inhibitors
2	kcat/KM [mM/s]
63	Ki Value [mM]
143	KM Value [mM]
60	Localization
250	Metals/Ions
105	Molecular Weight [Da]
121	Natural Substrates/ Products (Substrates)
295	Organism
6	Pathway
75	PDB ID
27	pH Optimum
4	pH Range
2	pH Stability
17	pI Value
6	Posttranslational Modification
34	Protein Variants
62	Purification (Commentary)
17	Reaction
20	Reaction Type
269	Reference
186	Source Tissue
92	Specific Activity [micromol/min/mg]
5	Storage Stability
354	Substrates and Products (Substrate)
76	Subunits
337	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Stability [°C]
56	Turnover Number [1/s]

pI Value

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pI Value on EC 4.4.1.5 - lactoylglutathione lyase

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4.8

Lactococcus lactis

Q9CJC0

calculated from sequence, 30fold upregulated protein spot in the 2D-electrophoresis, identified as glyoxalase I, the expression is regulated by the operon yahCD-yaiAB

4.9

chromatofocusing

5.2

calculated from amino acid sequence

5.3

isoelectric focusing

5.4

calculated from amino acid sequence

709889

Starmerella magnoliae

D6QLX5

calculated

715887

6.5

Clostridium acetobutylicum

Q97H22

His6-tagged enzyme, sequence calculation

7.8

8.1

mitochondrial form of Oryza sativa gly I

692050

8.59

Plasmodium falciparum

calculated

664268

additional information

7 entries