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4.4.1.5: lactoylglutathione lyase

This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.

Word Map on EC 4.4.1.5

Reaction

(R)-S-lactoylglutathione
=
glutathione
 +
2-oxopropanal

Synonyms

aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.5 lactoylglutathione lyase

Source Tissue

Source Tissue on EC 4.4.1.5 - lactoylglutathione lyase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
the enzyme is absent from the necrotic core of atherosclerotic plaques
Manually annotated by BRENDA team
-
MDA-MD-231 cell, JIMT-1 cell
Manually annotated by BRENDA team
-
the highest glyoxalase I concentration is found in mature bulbs
Manually annotated by BRENDA team
-
high expression level
Manually annotated by BRENDA team
in situ hybridization experiments, Purkinje cells in the cerebellum express GLO1 mRNA strongly and specifically
Manually annotated by BRENDA team
in situ hybridization experiments, highest expression at postnatal day 14
Manually annotated by BRENDA team
in situ hybridization experiments, highest expression at postnatal day 14
Manually annotated by BRENDA team
in situ hybridization experiments, lining the third ventricle and choroid plexus
Manually annotated by BRENDA team
in situ hybridization experiments, highest expression at postnatal day 14
Manually annotated by BRENDA team
-
human dermal microvascular endothelial cell
Manually annotated by BRENDA team
-
breast cancer cell
Manually annotated by BRENDA team
transcription level and glyoxalase I activity are higher in pathological tissues than in normal ones
Manually annotated by BRENDA team
-
Bcr-Abl+ leukemic stem cell
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
breast cancer cell
Manually annotated by BRENDA team
-
prostate cancer cell
Manually annotated by BRENDA team
-
green
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
medial, high expression level
Manually annotated by BRENDA team
in situ hybridization experiments, highest expression at postnatal day 14
Manually annotated by BRENDA team
-
found to be conserved in tubers among different potato variants
Manually annotated by BRENDA team
in situ hybridization experiments, GLO1 is dominantly expressed in the embryonic ventricular zone at day 16, reducing the celluar level of methylglyoxal and suppressing the formation of argpyrimidine in the neural stem and progenitor cells
Manually annotated by BRENDA team
additional information