4.4.1.5: lactoylglutathione lyase
This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.
Word Map on EC 4.4.1.5
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4.4.1.5
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glycation
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detoxify
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gsh
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dicarbonyls
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erythrocyte
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d-lactate
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adduct
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dismutase
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endproducts
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rage
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s-transferase
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mellitus
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methylglyoxal-induced
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glyoxalases
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byproduct
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hyperglycemia
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glutathione-dependent
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phosphoglucomutase
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metalloenzyme
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hemithioacetal
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mg-induced
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hla-a
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aldose
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3-deoxyglucosone
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enediolate
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d-lactic
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pentosidine
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cyclopentyl
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mdhar
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haptoglobin
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aminoguanidine
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diesters
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monodehydroascorbate
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6-phosphogluconate
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anti-glycation
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dehydroascorbate
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anxiety-like
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gsh-dependent
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pyridoxamine
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analysis
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trypanothione
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medicine
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drug development
- 4.4.1.5
-
glycation
-
detoxify
- gsh
-
dicarbonyls
- erythrocyte
- d-lactate
- adduct
- dismutase
-
endproducts
- rage
- s-transferase
- mellitus
-
methylglyoxal-induced
-
glyoxalases
-
byproduct
- hyperglycemia
-
glutathione-dependent
- phosphoglucomutase
-
metalloenzyme
- hemithioacetal
-
mg-induced
- hla-a
- aldose
- 3-deoxyglucosone
-
enediolate
-
d-lactic
-
pentosidine
-
cyclopentyl
- mdhar
- haptoglobin
- aminoguanidine
- diesters
- monodehydroascorbate
- 6-phosphogluconate
-
anti-glycation
- dehydroascorbate
-
anxiety-like
-
gsh-dependent
- pyridoxamine
- analysis
- trypanothione
- medicine
- drug development
Reaction
Synonyms
aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA
ECTree
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Reaction
Reaction on EC 4.4.1.5 - lactoylglutathione lyase
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
there is a single site for the binding of the hemimercaptal of methylglyoxal and glutathione, for the binding of glutathione, and for the binding of S-substituted derivatives of glutathione. One-substrate reaction mechanism with hemimercaptal being the substrate, but does not rule out the possibility of the alternate branches
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
intramolecular hydride migration is the rate-determining step
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
comparative study of methylgloxal metabolism in trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi und Leishmania major. Trypanosoma brucei lacks GLO1 activity. Overexpression of GLO1 from Trypanosoma cruzi in Trypanosoma brucei results in restoration of the glyoxalase system resulting in an increased resistance to methylglyoxal and increased conversion of methylglyoxal to D-lactate, demonstratong that glyoxalase II (GLO2, EC 3.1.2.6) is functional in vivo
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
comparative study of methylgloxal metabolism in trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi und Leishmania major. Trypanosoma brucei lacks GLO1 activity. Overexpression of GLO1 from Trypanosoma cruzi in Trypanosoma brucei results in restoration of the glyoxalase system resulting in an increased resistance to methylglyoxal and increased conversion of methylglyoxal to D-lactate, demonstratong that glyoxalase II (GLO2, EC 3.1.2.6) is functional in vivo
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
investigation of the biological role of GLO I in renal hypoxic diseases by using the rat ischemia/reperfusion (I/R) injury model. I/R induces the reduction of renal GLO I activity associated with morphological changes and renal dysfunction
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(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
methylglyoxal and glutathione form an intermediate, the hemithioacetal, which is catalyzed to S-D-lactoylglutathione by GlxI. Subsequently S-D-lactoylglutathione is hydrolyzed to D-lactate and glutathione by GlxII (EC 3.1.2.6)
(R)-S-lactoylglutathione = glutathione + 2-oxopropanal
comparative study of methylgloxal metabolism in trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi und Leishmania major. Trypanosoma brucei lacks GLO1 activity. Overexpression of GLO1 from Trypanosoma cruzi in Trypanosoma brucei results in restoration of the glyoxalase system resulting in an increased resistance to methylglyoxal and increased conversion of methylglyoxal to D-lactate, demonstratong that glyoxalase II (GLO2, EC 3.1.2.6) is functional in vivo
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