4.4.1.5: lactoylglutathione lyase
This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.
Word Map on EC 4.4.1.5
-
4.4.1.5
-
glycation
-
detoxify
-
gsh
-
dicarbonyls
-
erythrocyte
-
d-lactate
-
adduct
-
dismutase
-
endproducts
-
rage
-
s-transferase
-
mellitus
-
methylglyoxal-induced
-
glyoxalases
-
byproduct
-
hyperglycemia
-
glutathione-dependent
-
phosphoglucomutase
-
metalloenzyme
-
hemithioacetal
-
mg-induced
-
hla-a
-
aldose
-
3-deoxyglucosone
-
enediolate
-
d-lactic
-
pentosidine
-
cyclopentyl
-
mdhar
-
haptoglobin
-
aminoguanidine
-
diesters
-
monodehydroascorbate
-
6-phosphogluconate
-
anti-glycation
-
dehydroascorbate
-
anxiety-like
-
gsh-dependent
-
pyridoxamine
-
analysis
-
trypanothione
-
medicine
-
drug development
- 4.4.1.5
-
glycation
-
detoxify
- gsh
-
dicarbonyls
- erythrocyte
- d-lactate
- adduct
- dismutase
-
endproducts
- rage
- s-transferase
- mellitus
-
methylglyoxal-induced
-
glyoxalases
-
byproduct
- hyperglycemia
-
glutathione-dependent
- phosphoglucomutase
-
metalloenzyme
- hemithioacetal
-
mg-induced
- hla-a
- aldose
- 3-deoxyglucosone
-
enediolate
-
d-lactic
-
pentosidine
-
cyclopentyl
- mdhar
- haptoglobin
- aminoguanidine
- diesters
- monodehydroascorbate
- 6-phosphogluconate
-
anti-glycation
- dehydroascorbate
-
anxiety-like
-
gsh-dependent
- pyridoxamine
- analysis
- trypanothione
- medicine
- drug development
Reaction
Synonyms
aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA
ECTree
4.4.1.5 lactoylglutathione lyaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.4.1.5 - lactoylglutathione lyase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
methylglyoxal + glutathione
(R)S-lactoylglutathione
Amaranthus sp.
-
first step in the glyoxalase system
-
-
r
methylglyoxal + glutathione
S-((R)-lactoyl)glutathione
-
glyoxalase I is a member of the metallogltathione transferase superfamily and plays a critical role in detoxification of the cytotoxic methylglyoxal to S-D-lactoylglutathione via 1,2-hydrogen transfer
-
-
?
trypanothione + 2 methylglyoxal
5,5'-bi((R)-lactoyl)trypanothione
-
-
-
-
?
glutathione + methylglyoxal
(R)-S-lactoylglutathione
-
-
-
-
?
glutathione + methylglyoxal
(R)-S-lactoylglutathione
-
-
-
r
glutathione + methylglyoxal
?
-
detoxification of methylglyoxal
-
-
?
glutathione + methylglyoxal
?
-
detoxification of methylglyoxal
-
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione, Gly-I may play a critical detoxifying role in glycolysis to maintain cellular activity and viability of prostatic cancer cells
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione, operates in conjunction with glyoxalase II to convert cytotoxic methylglyoxal to nontoxic D-lactate
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
-
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
glutathione-methylglyoxal hemithioacetal
(R)-S-lactoylglutathione
glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione
-
?
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
first step in the glyoxalase system, detoxification of methylglyoxal
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
-
-
-
?
methylglyoxal + glutathione
(R)-S-lactoylglutathione
first step in the glyoxalase system, detoxification of methylglyoxal
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system, detoxification of methylglyoxal
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
first step in the glyoxalase system, detoxification of methylglyoxal
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system, detoxification of methylglyoxal
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
first step in the glyoxalase system, detoxification of methylglyoxal
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
first step in the glyoxalase system, detoxification of methylglyoxal
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
-
-
-
?
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system
-
-
r
methylglyoxal + glutathione
(R)-S-lactoylglutathione
-
first step in the glyoxalase system, detoxification of methylglyoxal
-
-
r
trypanothione + methylglyoxal
5,5'-bi((R)-lactoyl)trypanothione
-
-
-
-
?
trypanothione + methylglyoxal
5,5'-bi((R)-lactoyl)trypanothione
-
-
-
-
?
trypanothione + methylglyoxal
5,5'-bi((R)-lactoyl)trypanothione
-
-
-
-
?
trypanothione + methylglyoxal
5,5'-bi((R)-lactoyl)trypanothione
-
-
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
Amaranthus sp.
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
disinfected water from two drinking water production plants at the river Po in North Italy markedly perturb the crap liver detoxfifying system, in terms of both induction and inhibition of enzyme activities and glutathione content
-
-
?
additional information
?
-
the enzyme is a part of the glyoxalase system that is composed of EC 4.4.1.5 and EC 3.1.2.6. The glyoxalase system converts toxic alpha-keto aldehydes into their corresponding nontoxic 2-hydroxycarboxylic acids
-
-
?
additional information
?
-
-
the enzyme is a part of the glyoxalase system that is composed of EC 4.4.1.5 and EC 3.1.2.6. The glyoxalase system converts toxic alpha-keto aldehydes into their corresponding nontoxic 2-hydroxycarboxylic acids
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
the enzyme is a part of the glyoxalase system that is composed of EC 4.4.1.5 and EC 3.1.2.6. The glyoxalase system converts toxic alpha-keto aldehydes into their corresponding nontoxic 2-hydroxycarboxylic acids
-
-
?
additional information
?
-
-
the enzyme is associated with cell proliferation, the activity is modulated during the proliferation cycle with a maximal activity between day 2 and day 4 of culture growth
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
overexpression of the enzyme completely prevents both hyperglycemia-induced advanced glycation products from methylglyoxal and increased macromolecular endocytosis
-
-
?
additional information
?
-
-
Glo1 is the major cellular enzyme that catalyzes the metabolism of methylglyoxal and thereby protects against dicarbonyl glycation
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the Leishmania sp. glxI preferentially utilizes the hemithioacetal formed between methylglyoxal and trypanothione as the substrate
-
-
?
additional information
?
-
-
glyoxalase system containing glyoxalase I and II catalyzes the conversion of 2-oxoaldehydes into their corresponding 2-hydroxyacids
-
-
?
additional information
?
-
-
major cellular function of glycolase I is the inactivation of methylglyoxal, a toxic by-product of the triose phosphate isomerase reaction of glycolysis
-
-
?
additional information
?
-
-
reaction involves abstraction of a proton from carbon 1 and reinsertion of the proton at carbon 2. Proton transfer takes place with limited proton exchange with the surrounding medium, and a hydride transfer is involved. In the absence of substrate or product, the metal is coordinated with 2 water molecules in addition to the side chains of Gln33 and Glu99 in the same subunit and His126 and Glu172 from the neighbouring subunit. During the catalytic process the water molecule are displaced by the incoming substrate. Glu172 serves as the acid-base in the catalytic mechanism.
-
-
?
additional information
?
-
-
alpha-ketoaldehydes may be formed in cells during oxidative processes, glyoxalase I is the main enzyme involved in the detoxification pathway for these highly toxic compounds
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
glyoxalase I activity is involved in the detoxification of toxic metabolites produced during lipid peroxidation
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
together with the second enzyme of the glyoxalase system, EC3.1.2.6, EC4.4.1.5 may detoxify the electrophilic 2-oxoaldehydes which can be formed in the cell from endogenous precursors
-
-
?
additional information
?
-
-
glyoxalase I catalyzes the isomerization reaction of thiohemiacetal, which is formed nonenzymatically from methylglyoxal and glutathione
-
-
?
additional information
?
-
-
study of the pathophysiological role of glyaylase I as an methylglyxal detoxifier in rat ischemia-reperfusion (I/R) injury
-
-
?
additional information
?
-
-
the glyoxalase system detoxifies methylglyoxal and is composed of two enzymes: glyoxylase I (GLO I), which metabolizes methylglyoxal to S-D-lactoylglutathione, and glyoxalase II (GLO II, EC 3.1.2.6) which converts S-D-lactoylglutathione to D-lactate
-
-
?
additional information
?
-
-
may serve to detoxify methylglyoxal produced from triosephosphates. Increased expression of glyoxalase I may be linked to a higher demand for ATP generation and to enhanced glycolysis in salt-stressed plants
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
additional information
?
-
-
the glyoxalase system is an ubiquitous pathway for the detoxification of highly reactive ketoaldehydes
-
-
?
