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4.4.1.5: lactoylglutathione lyase

This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.

Word Map on EC 4.4.1.5

Reaction

(R)-S-lactoylglutathione
=
glutathione
 +
2-oxopropanal

Synonyms

aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.5 lactoylglutathione lyase

KM Value

KM Value on EC 4.4.1.5 - lactoylglutathione lyase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.016 - 0.12
(R)-S-lactoylglutathione
0.07
2,4-dimethylphenylglyoxal
-
liver or erythrocyte enzyme
0.87 - 1.2
4,5-Dioxovalerate
0.02
4-bromophenylglyoxal, 4-methylphenylglyoxal
-
liver or erythrocyte enzyme
-
0.06
alpha-deuteriophenylglyoxal
-
-
0.2
gamma-glutamylcysteine-methylglyoxal hemithioacetal
30°C, pH 7.5
0.24
gamma-glutamylcysteine-phenylglyoxal hemithioacetal
30°C, pH 7.5
0.049 - 1.9
glutathione
0.042 - 0.7
glutathione ethyl ester
0.053 - 0.3
glutathione isopropyl ester
0.58
glutathione-glyoxal hemithioacetal
-
0.025
glutathione-methylglyoxal
30°C, pH 7.5
0.0089 - 11
glutathione-methylglyoxal hemithioacetal
0.049
glutathione-phenylglyoxal
30°C, pH 7.5
0.008 - 0.014
glutathionylspermidine
0.066
homoglutathione-methylglyoxal
30°C, pH 7.5
0.027
homoglutathione-phenylglyoxal
30°C, pH 7.5
0.2
kethoxal
-
-
0.03
m-methoxyphenylglyoxal
-
liver or erythrocyte enzyme
0.016 - 3.5
methylglyoxal
0.46
methylglyoxal/glutathione hemithioacetal
-
-
-
0.064 - 0.148
N-[3-[(4-aminobutyl)amino]propyl]-L-gamma-glutamyl-L-cysteinylglycine
0.02
p-chlorophenylglyoxal
-
liver or erythrocyte enzyme
0.03
p-hydroxyphenylglyoxal
-
liver or erythrocyte enzyme
0.01
p-methoxyphenylglyoxal
-
liver or erythrocyte enzyme
0.02
p-phenylphenylglyoxal
-
liver or erythrocyte enzyme
0.19
perdeuteriomethylglyoxal
-
-
0.04 - 0.31
Phenylglyoxal
0.0284
reduced trypanothione
recombinant enzyme, pH 7.2, room temperature
0.032
S-D-lactoyltrypanothione
purified enzyme, pH 7.0, 27°C
0.051
S-mandoyltrypanothione
purified enzyme, pH 7.0, 27°C
0.071 - 0.207
trypanothione
additional information
(R)-S-lactoylglutathione