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4.4.1.5: lactoylglutathione lyase

This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.

Word Map on EC 4.4.1.5

Reaction

(R)-S-lactoylglutathione
=
glutathione
 +
2-oxopropanal

Synonyms

aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.5 lactoylglutathione lyase

IC50 Value

IC50 Value on EC 4.4.1.5 - lactoylglutathione lyase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.002
(3Z)-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid
Homo sapiens
-
pH 7.0, 25°C
0.00828
1'-hydroxy-6'-phenyl-3,4'-bipyridin-2'(1'H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00119
1-hydroxy-4,6-diphenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00028
1-hydroxy-4-phenyl-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00051
1-hydroxy-6-(1-pentyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-phenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00025
1-hydroxy-6-(1H-indol-5-yl)-4-phenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00152
1-hydroxy-6-phenyl-4-(thiophen-3-yl)pyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00813
1-hydroxy-6-phenyl-4-[4-(trifluoromethyl)phenyl]pyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00026
1-hydroxy-6-[1-(2-methoxyethyl)-1H-indol-5-yl]-4-phenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000014
1-hydroxy-6-[1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-4-phenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
1-hydroxy-6-[1-(3-methoxypropyl)-1H-indol-5-yl]-4-phenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
1-hydroxy-6-[1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-4-phenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0546
2-([(4-methoxyphenyl)carbonyl]amino)-1-benzothiophene-3-carboxylic acid
Homo sapiens
-
pH 7.0, 25°C
0.0932
2-([(4-methoxyphenyl)carbonyl]amino)benzoic acid
Homo sapiens
-
pH 7.0, 25°C
0.00048
3-[[5-(1-hydroxy-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)-1H-indol-1-yl]methyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00004
3-[[5-(1-hydroxy-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-1-yl]methyl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0084
4-(biphenyl-4-yl)-1-hydroxy-6-phenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.01
4-(but-1-yn-1-yl)-1-hydroxy-6-phenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.01
4-butyl-1-hydroxy-6-phenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
6-(1-butyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-1-hydroxy-4-phenylpyridin-2(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.011
baicalein
Homo sapiens
indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0
0.056 - 0.069
flavone
0.0206
kaempferol
Homo sapiens
indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0
0.093 - 0.096
Lapachol
0.007
luteolin
Homo sapiens
indicate that the hydroxy groups at the B ring of flavonoids contribute to the human GLO I inhibitory activity of the flavonoid compounds at 25°C, pH 7.0
0.00056
myricetin
0.07 - 0.132
purpurogallin
0.0032 - 0.027
quercetin
0.00006
S-(N-hydroxy-N-bromophenylcarbamoyl)gluthatione
0.00009 - 0.00011
S-(N-hydroxy-N-chlorophenylcarbamoyl)gluthatione
0.0025 - 0.01
S-(N-hydroxy-N-phenylcarbamoyl)gluthatione
0.021
S-(p-bromobenzyl)glutathione
Homo sapiens
-
pH and temperature not specified in the publication
0.0332
S-4-bromobenzylglutathione
Homo sapiens
-
pH 7.0, 25°C
0.023
S-p-bromobenzylglutathione
Homo sapiens
calculated, effectively inhibits rhGLO I at 25°C, pH 7.0