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4.4.1.5: lactoylglutathione lyase

This is an abbreviated version!
For detailed information about lactoylglutathione lyase, go to the full flat file.

Word Map on EC 4.4.1.5

Reaction

(R)-S-lactoylglutathione
=
glutathione
 +
2-oxopropanal

Synonyms

aldoketomutase, CLO GlxI, Glb33, GLI, GLO I, GLO-1, GLO-I, Glo1, GloA, GloA1, GloA2, GloA3, GloI, Glx I, Glx-I, Glx1, GLXI, Gly I, gly-I, GLY1, glyoxalase 1, glyoxalase I, glyoxalase-1, glyoxalase-I, glyoxylase I, GmGlyox I, ketone-aldehyde mutase, lactoylglutathione lyase, lactoylglutathione methylglyoxal lyase, LGL, lyase, lactoylglutathione, methylglyoxalase, methylglyoxylase, OsGLYI-11.2, PfGlx I, rhGLO I, S-D-lactoylglutathione methylglyoxal lyase, S-D-lactoylglutathione methylglyoxal lyase (isomerizing), S-D-lactoylglutathione:methylglyoxal lyase, SpGlo1, STM3117, YaiA

ECTree

     4 Lyases
         4.4 Carbon-sulfur lyases
             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)
                4.4.1.5 lactoylglutathione lyase

Expression

Expression on EC 4.4.1.5 - lactoylglutathione lyase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
activation of receptor for advanced glycation endproducts by S100A12 protein decreases the expression of glyoxalase 1
-
activity of glyoxalase I decreased under NaCl stress, at 48 h of NaCl stress the decrease is maximum
-
aged ovaries show a 2.9fold decreased protein level and a 1.4fold decreased RNA level of GLO1
-
compared with the respective parental cells, hypoxia adapted-Bcr-Abl+ cells have higher levels of protein and higher enzyme activity of glyoxalase-I. High Glo-I expression is sustained in hypoxia adapted-chronic myeloid leukemia cells after 6 months in normoxia
-
expression of GLO1 is induced by stress inducers such as methylglyoxal, H2O2, KCl, and NaCl
GLI expression is not affected by ursolic acid
-
Gly I expression is induced by the inoculation of Fusarium graminearum in wheat spikes, the magnitude of Gly I mRNAs enhances significantly about twofold in 100 mM NaCl, however, with the increase of NaCl concentration to 150 and 500 mM, the Gly I mRNAs decrease to the similar level as control. When treated with ZnCl2, the mRNA level of Gly I in leaves increases gradually with the increase of ZnCl2 concentration
-
Gly-I activity in N-acetylcysteine-exposed cells is 40% higher than that in control cells
-
glyoxlase I activity decreases in heavy metal stress (exposure to 0.5 mM CdCl2)
-
glyoxylase I expression is upregulated up to 10fold at the mRNA and protein level in metastatic melanoma tissue
-
high Glo1 expression is strongly associated with high anxiety-like behavior in mice
-
in the human lens, GLOI activity and immunoreactivity both decrease with age
-
low temperature (4°C) stress shows the highest induction (2.6fold) of glyoxalase I activity, followed by salinity (exposure to 400 mM NaCl) and drought (exposure to 10% (v/v) PEG) stress for 7 days
-
maximum expression at the exponential growth phase
methylglyoxal-mediated anxiolysis involves elevated expression of glyoxalase 1 in the brain, methylglyoxal treatment increases expression of GLO1 only in CD1 mice that do not have extra copies of GLO1. GLO1 expression is ubiquitously elevated in low-anxiety-related behavior-phenotype brain. Methylglyoxal injections into the lateral ventricle of hyper-anxious-related behavior-phenotype mice enhance GLO1 expression
-
oleanolic acid treatments at 0.1 or 0.2% (v/v) dose-dependently enhances renal glyoxalase I activity and up-regulates renal glyoxalase I mRNA expression
-
quantification of protein abundance in cerebellar tissue reveals, after normalization, a significant 3.9fold increase of GLO1 in 14N labeled LABs compared to 15N labeled high anxious behavior-mice
-
the activity of glyoxalase I increases with increasing NaCl concentration, activity of glyoxalase I is significantly increased 1.2, 1.3, and 1.6fold more than control plants for 450, 600, and 750 mM NaCl treatment, respectively
-
the enzyme is highly substrate-inducible
the expression of GLO1 is induced following treatment with Ca2+ and is dependent on the mitogen-activated protein kinase Hog1 protein and the Msn2/Msn4 transcription factors, the Ca2+-induced expression of GLO1 is enhanced in the presence of FK506
the promoter of Glo1 harbours an nuclear factor kappaB-responsive element, indicating a link between inflammation and reduced Glo1 expression
-
troglitazone downregulates GLO-1 expression
-
troglitazone treatment (0.025-0.1 mM) reduces glyoxalase I protein expression in glioma
-