4.4.1.4: alliin lyase
This is an abbreviated version!
For detailed information about alliin lyase, go to the full flat file.
Word Map on EC 4.4.1.4
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4.4.1.4
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garlic
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allium
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allicin
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sativum
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onion
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thiosulfinates
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crush
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clove
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organosulfur
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s-alkenyl-l-cysteine
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alliaceae
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leek
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s-allyl-l-cysteine
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lachrymatory
-
medicine
-
acsos
-
s-allyl
-
synthesis
-
nutrition
-
drug development
-
biotechnology
-
analysis
-
pharmacology
- 4.4.1.4
- garlic
- allium
- allicin
- sativum
- onion
- thiosulfinates
-
crush
- clove
-
organosulfur
-
s-alkenyl-l-cysteine
- alliaceae
- leek
- s-allyl-l-cysteine
-
lachrymatory
- medicine
-
acsos
-
s-allyl
- synthesis
- nutrition
- drug development
- biotechnology
- analysis
- pharmacology
Reaction
Synonyms
alkylcysteine sulfoxide lyase, alkylsulphenate lyase, ALL1, alliin lyase, alliin-lyase, alliinase, alliinase I, alliinase II, allinase, C-S lyase, C-S-lyase, cys sulfoxide lyase, cysteine sulfoxide lyase, Cysteine sulphoxide lyase, L-(+)-S-alk(en)ylcysteine sulfoxide lyase, L-cysteine sulfoxide lyase, lyase, alliin, More, P-19486 alliinase, S-alkyl(en)yl-L-cysteine lyase, S-alkylcysteine sulfoxide lyase
ECTree
4.4.1.4 alliin lyaseAdvanced search results
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Reference on EC 4.4.1.4 - alliin lyase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kitamura, N.; Shimomura, N.; Iseki, J.; Honma, M.; Chiba, S.; Tahara, S.; Mizutani, J.
Cysteine-S-conjugate beta-lyase activity and pyridoxal phosphate binding site of onion alliin lyase
Biosci. Biotechnol. Biochem.
61
1327-1330
1997
Allium cepa
Lancaster, J.E.; Collin, H.A.
Presence of alliinase in isolated vacuoles and of alkyl cysteine suphoxides in the cytoplasm of bulbs of onion (Allium cepa)
Plant Sci. Lett.
22
169-176
1981
Allium cepa
-
Iwami, K.; Yasumoto, K.
Aliinase-like enzymes in fruiting bodies of Lentinus edodes: their purification and substrate specificity
Agric. Biol. Chem.
44
3003-3004
1980
Lentinula edodes
-
Won, T.; Mazelis, M.
The C-S lyases of higher plants. Purification and characterization of homogeneous alliin lyase of leek (Allium porrum)
Physiol. Plant.
77
87-92
1989
Allium ampeloprasum
-
Tobkin, H.E.; Mazelis, M.
Alliin lyase: preparation and characterization of the homogeneous enzyme from onion bulbs
Arch. Biochem. Biophys.
193
150-157
1979
Allium cepa
Durbin, R.D.; Uchytil, T.F.
Purification and properties of alliin lyase from the fungus Penicillium corymbiferum
Biochim. Biophys. Acta
235
518-520
1971
Penicillium hirsutum
-
Jacobsen, J.V.; Yamaguchi, M.; Howard, F.D.; Bernhard, R.A.
Product inhibition of the cysteine sulfoxide lyase of Tulbaghia violacea
Arch. Biochem. Biophys.
127
252-258
1968
Tulbaghia violacea
-
Nock, L.P.; Mazelis, M.
The C-S lyases of higher plants. Direct comparison of the physical properties of homogeneous alliin lyase of garlic (Allium sativum) and onion (Allium cepa)
Plant Physiol.
85
1079-1083
1987
Allium cepa, Allium sativum
Nock, L.P.; Mazelis, M.
The C-S lyases of higher plants: preparation and properties of homogeneous alliin lyase from garlic (Allium sativum)
Arch. Biochem. Biophys.
249
27-33
1986
Allium sativum
Peumans, W.J.; Smeets, K.; van Nerum, K.; van Leuven, F.; van Damme, E.J.H.
Lectin and alliinase are the predominant proteins in nectar from leek (Allium porrum L.) flowers
Planta
201
298-302
1997
Allium ampeloprasum
Iwami, K.; Yasumoto, K.; Mitsuda, H.
Enzymatic cleavage of cysteine sulfoxide in Lentinus edodes
Agric. Biol. Chem.
39
1947-1955
1975
Lentinula edodes
-
Jansen, H.; Muller, B.; Knobloch, K.
Alliin lyase from garlic, Allium sativum: investigations on enzyme/substrate, enzyme/inhibitor interactions and on a new coenzyme
Planta Med.
55
440-445
1989
Allium sativum
Van Damme, E.J.M.; Smeets, K.; Torrekens, S.; van Leuven, F.; Peumans, W.J.
Isolation and characterization of alliinase cDNA clones from garlic (Allium sativum L.) and related species
Eur. J. Biochem.
209
751-757
1992
Allium cepa var. aggregatum, Allium sativum
Rabinkov, A.; Zhu, X.Z.; Grafi, G.; Galili, G.; Mirelman, D.
Alliin lyase (Alliinase) from garlic (Allium sativum). Biochemical characterization and cDNA cloning
Appl. Biochem. Biotechnol.
48
149-171
1994
Allium sativum
Smeets, K.; van Damme, E.J.M.; van Leuven, F.; Peumans, W.J.
Isolation and characterization of lectins and lectin-alliinase complexes from bulbs of garlic (Allium sativum) and ramsons (Allium ursinum)
Glycoconj. J.
14
331-343
1997
Allium sativum, Allium ursinum
Manabe, T.; Hasumi, A.; Sugiyama, M.; Yamazaki, M.; Saito, K.
Alliinase [S-alk(en)yl-L-cysteine sulfoxide lyase] from Allium tuberosum (Chinese chive): purification, localization, cDNA cloning and heterologous functional expression
Eur. J. Biochem.
257
21-30
1998
Allium tuberosum
Jansen, H.; Muller, B.; Knobloch, K.
Characterization of an alliin lyase preparation from garlic (Allium sativum)
Planta Med.
55
434-439
1989
Allium sativum
Krest, I.; Keusgen, M.
Stabilization and pharmaceutical use of alliinase
Pharmazie
54
289-293
1999
Allium sativum
Weik, R.; Francky, A.; Striedner, G.; Raspor, P.; Bayer, K.; Mattanovich, D.
Recombinant expression of alliin lyase from garlic (Allium sativum) in bacteria and yeasts
Planta Med.
64
387-389
1998
Allium sativum
Fujita, M.; Endo, M.; Sano, M.
Purification and characterization of alliin lyase from welsh onion, Allium fistulosum L.
Agric. Biol. Chem.
54
1077-1079
1990
Allium fistulosum
-
Rabinkov, A.; Wilchek, M.; Mirelman, D.
Alliinase (alliin lyase) from garlic (Alliium sativum) is glycosylated at Asn146 and forms a complex with a garlic mannose-specific lectin
Glycoconj. J.
12
690-698
1995
Allium sativum
Krest, I.; Keusgen, M.
Quality of herbal remedies from Allium sativum: differences between alliinase from garlic powder and fresh garlic
Planta Med.
65
139-143
1999
Allium sativum
Schwimmer, S.
S-Alkyl-L-cysteine sulfoxide lyase [Allium cepa (onion)]
Methods Enzymol.
17B
475-478
1971
Allium cepa
-
Shimon, L.J.; Rabinkov, A.; Miron, T.; Mirelman, D.; Wilchek, M.; Frolow, F.
Alliin lyase (alliinase) from garlic (Allium sativum): crystallization and preliminary X-ray characterization
Acta Crystallogr. Sect. D
58
1335-1337
2002
Allium sativum
Kuettner, E.B.; Hilgenfeld, R.; Weiss, M.S.
Purification, characterization, and crystallization of alliinase from garlic
Arch. Biochem. Biophys.
402
192-200
2002
Allium sativum
Jin, Y.N.; Choi, Y.H.; Yang, C.H.
Identification of an essential tryptophan residue in alliinase from garlic (Allium sativum) by chemical modification
Bull. Korean Chem. Soc.
22
68-76
2001
Allium sativum
-
Krest, I.; Glodek, J.; Keusgen, M.
Cysteine sulfoxides and alliinase activity of some Allium species
J. Agric. Food Chem.
48
3753-3760
2000
Allium sativum, Allium sphaerocephalon, Allium victorialis, Allium hymenorrhizum, Allium saxatile, Allium obliquum, Allium subhirsutum, Allium jesdianum, Allium stipitatum
Lawson, L.D.; Wang, Z.J.
Low allicin release from garlic supplements: a major problem due to the sensitivities of alliinase activity
J. Agric. Food Chem.
49
2592-2599
2001
Allium sativum
Keusgen, M.; Schulz, H.; Glodek, J.; Krest, I.; Kruger, H.; Herchert, N.; Keller, J.
Characterization of some Allium hybrids by aroma precursors, aroma profiles, and alliinase activity
J. Agric. Food Chem.
50
2884-2890
2002
Allium altyncolicum, Allium cepa * Allium altyncolicum, Allium cepa * Allium chevsuricum, Allium cepa * Allium globosum, Allium cepa * Allium oliquum, Allium cepa * Allium saxatile, Allium cepa * Allium senescens
Yamazaki, M.; Sugiyama, M.; Saito, K.
Intercellular localization of cysteine synthase and alliinase in bundle sheaths of Allium plants
Plant Biotechnol.
19
7-10
2002
Allium cepa, Allium sativum, Allium tuberosum
-
Lancaster, J.E.; Shaw, M.L.; Joyce, M.D.; McCallum, J.A.; McManus, M.T.
A novel alliinase from onion roots. Biochemical characterization and cDNA cloning
Plant Physiol.
122
1269-1279
2000
Allium cepa, Leucocoryne angustipetala, Leucocoryne purpurea, Leucocoryne coquimbensis, Leucocoryne odorata
Do, G.S.; Suzuki, G.; Mukai, Y.
Genomic organization of a novel root alliinase gene, ALL1, in onion
Gene
325
17-24
2004
Allium cepa
Fry, F.H.; Okarter, N.; Baynton-Smith, C.; Kershaw, M.J.; Talbot, N.J.; Jacob, C.
Use of a substrate/alliinase combination to generate antifungal activity in situ
J. Agric. Food Chem.
53
574-580
2005
Allium ursinum
Kao, S.H.; Hsu, C.H.; Su, S.N.; Hor, W.T.; Chang T.W.H.; Chow, L.P.
Identification and immunologic characterization of an allergen, alliin lyase, from garlic (Allium sativum)
J. Allergy Clin. Immunol.
113
161-168
2004
Allium ampeloprasum, Allium cepa, Allium cepa var. aggregatum, Allium sativum
Miron, T.; SivaRaman, H.; Rabinkov, A.; Mirelman, D.; Wilchek, M.
A method for continuous production of allicin using immobilized alliinase
Anal. Biochem.
351
152-154
2006
Allium sativum
Imai, S.; Akita, K.; Tomotake, M.; Sawada, H.
Model studies on precursor system generating blue pigment in onion and garlic
J. Agric. Food Chem.
54
848-852
2006
Allium cepa, Allium sativum
Shimon, L.J.; Rabinkov, A.; Shin, I.; Miron, T.; Mirelman, D.; Wilchek, M.; Frolow, F.
Two structures of alliinase from Alliium sativum L.: apo form and ternary complex with aminoacrylate reaction intermediate covalently bound to the PLP cofactor
J. Mol. Biol.
366
611-625
2007
Allium sativum
Keusgen, M.
Unusual cystine lyase activity of the enzyme alliinase: direct formation of polysulphides
Planta Med.
74
73-79
2008
Allium sativum
Zhang, H.; Chen, Z.; Yang, G.; Wang, W.; Li, X.; Li, R.; Wu, Y.
Microwave pretreatment and gas chromatography-mass spectrometry determination of herbicide residues in onion
Food Chem.
108
322-328
2008
Allium cepa
Mendez Lagunas, L.L.; Castaigne, F.
Effect of temperature cycling on allinase activity in garlic
Food Chem.
111
56-60
2008
Allium sativum
Weiner, L.; Shin, I.; Shimon, L.J.; Miron, T.; Wilchek, M.; Mirelman, D.; Frolow, F.; Rabinkov, A.
Thiol-disulfide organization in alliin lyase (alliinase) from garlic (Allium sativum)
Protein Sci.
18
196-205
2009
Allium sativum (Q41233), Allium sativum
Zhou, J.
Immobilization of alliinase and its application: Flow-injection enzymatic analysis for alliin
Afr. J. Biotechnol.
8
1337-1342
2009
Allium sativum
-
Appel, E.; Vallon-Eberhard, A.; Rabinkov, A.; Brenner, O.; Shin, I.; Sasson, K.; Shadkchan, Y.; Osherov, N.; Jung, S.; Mirelman, D.
Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin
Antimicrob. Agents Chemother.
54
898-906
2010
Allium sativum
Zhou, J.; Wang, J.
Immobilization of alliinase with a water soluble-insoluble reversible N-succinyl-chitosan for allicin production
Enzyme Microb. Technol.
45
299-304
2009
Allium sativum
-
Kusterer, J.; Keusgen, M.
Cysteine sulfoxides and volatile sulfur compounds from Allium tripedale
J. Agric. Food Chem.
58
1129-1137
2010
Allium tripedale, Allium tripedale Trautv.
Kusterer, J.; Vogt, A.; Keusgen, M.
Isolation and identification of a new cysteine sulfoxide and volatile sulfur compounds from Allium subgenus Melanocrommyum
J. Agric. Food Chem.
58
520-526
2010
Allium stipitatum
Luo, D.; Guo, J.; Wang, F.; Jin, Z.; Cheng, X.; Zhu, J.; Peng, C.; Zhang, C.
Anti-fungal efficacy of polybutylcyanoacrylate nanoparticles of allicin and comparison with pure allicin
J. Biomat. Sci. Polym. Ed.
20
21-31
2009
Allium sativum
Musah, R.A.; He, Q.; Kubec, R.
Discovery and characterization of a novel lachrymatory factor synthase in Petiveria alliacea and its influence on alliinase-mediated formation of biologically active organosulfur compounds
Plant Physiol.
151
1294-1303
2009
Petiveria alliacea
Musah, R.A.; He, Q.; Kubec, R.; Jadhav, A.
Studies of a novel cysteine sulfoxide lyase from Petiveria alliacea: the first heteromeric alliinase
Plant Physiol.
151
1304-1316
2009
Petiveria alliacea
Kucerova, P.; Kubec, R.; Simek, P.; Vaclavik, L.; Schraml, J.
Allium discoloration: the precursor and formation of the red pigment in giant onion (Allium giganteum Regel) and some other subgenus Melanocrommyum species
J. Agric. Food Chem.
59
1821-1828
2011
Allium giganteum, Allium giganteum Regel
Kubec, R.; Krejcova, P.; Simek, P.; Vaclavik, L.; Hajslova, J.; Schraml, J.
Precursors and formation of pyrithione and other pyridyl-containing sulfur compounds in drumstick onion, Allium stipitatum
J. Agric. Food Chem.
59
5763-5770
2011
Allium stipitatum
Appel, E.; Rabinkov, A.; Neeman, M.; Kohen, F.; Mirelman, D.
Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma
J. Drug Target.
19
326-335
2011
Allium cepa
Yutani, M.; Taniguchi, H.; Borjihan, H.; Ogita, A.; Fujita, K.; Tanaka, T.
Alliinase from Ensifer adhaerens and its use for generation of fungicidal activity
AMB Express
1
2-2
2011
Ensifer adhaerens, Ensifer adhaerens FERM P-19486
Ko, J.A.; Lee, Y.L.; Jeong, H.J.; Park, H.J.
Preparation of encapsulated alliinase in alginate microparticles
Biotechnol. Lett.
34
515-518
2012
Allium sativum
Li, J.W.; Xia, L.; Su, Y.; Liu, H.; Xia, X.; Lu, Q.; Yang, C.; Reheman, K.
Molecular imprint of enzyme active site by camel nanobodies: rapid and efficient approach to produce abzymes with alliinase activity
J. Biol. Chem.
287
13713-13721
2012
Allium sativum
Zhang, H.; Xiao, W.; Zhao, D.; Liu, Y.; Hu, S.; Chen, C.; Xu, P.; Li, X.; Chen, J.
Fiber-optic in situ analysis of the catalytic kinetics of the alliin/alliinase system
J. Mol. Catal. B
106
111-116
2014
Allium sativum
-
Wang, J.; Cao, Y.; Wang, C.; Sun, B.
Low-frequency and low-intensity ultrasound accelerates alliinase-catalysed synthesis of allicin in freshly crushed garlic
J. Sci. Food Agric.
91
1766-1772
2011
Allium sativum
He, T.; Chambers, M.; Musah, R.
Application of direct analysis in real time-high resolution mass spectrometry to investigations of induced plant chemical defense mechanisms - revelation of negative feedback inhibition of an alliinase
Anal. Chem.
90
12802-12809
2018
Petiveria alliacea
Morozova, E.; Kulikova, V.; Rodionov, A.; Revtovich, S.; Anufrieva, N.; Demidkina, T.
Engineered Citrobacter freundii methionine gamma-lyase effectively produces antimicrobial thiosulfinates
Biochimie
128-129
92-98
2016
Citrobacter freundii (Q84AR1)
Kulikova, V.; Morozova, E.; Rodionov, A.; Koval, V.; Anufrieva, N.; Revtovich, S.; Demidkina, T.
Non-stereoselective decomposition of (+-)-S-alk(en)yl-l-cysteine sulfoxides to antibacterial thiosulfinates catalyzed by C115H mutant methionine gamma-lyase from Citrobacter freundii
Biochimie
151
42-44
2018
Citrobacter freundii (Q84AR1), Citrobacter freundii
Mitrova, K.; Svoboda, P.; Milella, L.; Ovesna, J.
Alliinase and cysteine synthase transcription in developing garlic (Allium sativum L.) over time
Food Chem.
251
103-109
2018
Allium sativum
Tao, D.; Zhou, B.; Zhang, L.; Hu, X.; Liao, X.; Zhang, Y.
Laba garlic processed by dense phase carbon dioxide the relation between green colour generation and cellular structure, alliin consumption and alliinase activity
J. Sci. Food Agric.
96
2969-2975
2016
Allium sativum
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