4.4.1.4: alliin lyase
This is an abbreviated version!
For detailed information about alliin lyase, go to the full flat file.
Word Map on EC 4.4.1.4
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4.4.1.4
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garlic
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allium
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allicin
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sativum
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onion
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thiosulfinates
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crush
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clove
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organosulfur
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s-alkenyl-l-cysteine
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alliaceae
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leek
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s-allyl-l-cysteine
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lachrymatory
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medicine
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acsos
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s-allyl
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synthesis
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nutrition
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drug development
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biotechnology
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analysis
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pharmacology
- 4.4.1.4
- garlic
- allium
- allicin
- sativum
- onion
- thiosulfinates
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crush
- clove
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organosulfur
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s-alkenyl-l-cysteine
- alliaceae
- leek
- s-allyl-l-cysteine
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lachrymatory
- medicine
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acsos
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s-allyl
- synthesis
- nutrition
- drug development
- biotechnology
- analysis
- pharmacology
Reaction
Synonyms
alkylcysteine sulfoxide lyase, alkylsulphenate lyase, ALL1, alliin lyase, alliin-lyase, alliinase, alliinase I, alliinase II, allinase, C-S lyase, C-S-lyase, cys sulfoxide lyase, cysteine sulfoxide lyase, Cysteine sulphoxide lyase, L-(+)-S-alk(en)ylcysteine sulfoxide lyase, L-cysteine sulfoxide lyase, lyase, alliin, More, P-19486 alliinase, S-alkyl(en)yl-L-cysteine lyase, S-alkylcysteine sulfoxide lyase
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Application on EC 4.4.1.4 - alliin lyase
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
analysis
biotechnology
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lachrymatory factor synthase and alliinase function in tandem, with the alliinase furnishing the sulfenic acid substrate on which the lachrymatory factor synthase acts. The lachrymatory factor synthase modulates the formation of biologically active thiosulfinates that are downstream of the alliinase in a manner dependent upon the relative concentrations of the lachrymatory factor synthase and the alliinase. These observations suggest that manipulation of lachrymatory factor synthase-to-alliinase ratios in plants displaying this system may provide a means by which to rationally modify organosulfur small molecule profiles to obtain desired flavor and/or odor signatures, or increase the presence of desirable biologically active small molecules
drug development
medicine
nutrition
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dense phase carbon dioxide has a significant effect on the greening of intact garlic (Allium sativum L.) cloves. The formation of the green colour is a comprehensive result of dense phase carbon dioxide on changing cellular structure, alliin consumption and alliinase activity. DPCD treatment at 10 MPa and 55°C is the optimum condition for the greening of Laba garlic
pharmacology
synthesis
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immobilized alliinase in reversibly soluble N-succinyl-chitosan is suitable to catalyze the conversion of alliin to allicin, as active ingredient of pharmaceutical compositions and food additive
additional information
analysis
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microwave inactivation of the enzyme alliinase, to eliminate the interference from alliinase sulfo products, is used for a rapid detection method for determination of herbicides in onions, overview
analysis
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Flow-injection enzymatic analytical system for determination of alliin based on the immobilized alliinase and an ammonia gas electrode provids linearity in the 1 × 10-5 to 1 × 10-3 mol/l alliin concentration range and exhibited good repeatability and operational stability
analysis
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development of a qRT-PCR assay that enables the quantification and normalisation of alliinase and cysteine synthase transcripts
drug development
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a monoclonal antibody (MAb) against Aspergillus fumigatus is produced and chemically ligated to the enzyme alliinase. The purified antibody-alliinase conjugate binds to conidia and hyphae of Aspergillus fumigatus at nanomolar concentrations. In the presence of alliin, the conjugate produces cytotoxic allicin molecules, which kills the fungus
drug development
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Pure allicin is prepared by reacting synthetic alliin with a stabilized process of the garlic enzyme alliinase. A novel drug vector, polybutylcyanoacrylate (PBCA) nanoparticles has been developed by emulsion polymerization method and wrapps the pure allicin into it. Minimal inhibitory fungal concentration (MIC) and minimal fungicidal concentration (MFC) of pure allicin and PBCA-allicin NPs against six fungus strains (Candida albicans, Cryputococcus neoformans, Trichophyton rubum, Microsporum gypseum, Microsporum canis and Epidermophyton floccosum) in vitro are used to evaluate their anti-fungal efficacy
medicine
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no clinical trial should be conducted with a garlic powder supplement that is not standardized upon dissolution allicin release for an effect of garlic that may be related to allicin, as most are
medicine
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a chemical conjugate between daidzein and the enzyme alliinase specifically binds to ovarian cancer cells and upon addition of the prodrug alliin, effectively produces cytotoxic allicin molecules which kill the cancer cells. Tumors show a five fold higher uptake as compared to other tissues. Treatment of tumor bearing mice with daidzein-alliinase and alliin effectively attenuates tumor progression during the first 12 days while a 5-fold increase in bioluminescence is detected in placebo-treated animals. Autopsy revealed only small individual foci of luminescence at the site of tumor cells inoculation. Histological examination of organs and tissues did not reveal any additional foci of carcinoma or signs of toxicity
medicine
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Allium sativum is used as a food, spice, and traditional medicine for many centuries. It has also antibacterial, antioxidant, anticancer and cholesterol-lowering effects, many health benefits associated with garlic can be attributed to thiosulfinates, especially allicin (2-propenyl 2-propenethiosulfinate) generated by the enzyme
pharmacology
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allicin contributes to the prevention of stroke and arteriosclerosis. An acid resistant capsule is filled with pellets of alliin and alliinase. In the intestine, alliin and alliinase are dissolved and alicin is liberated
pharmacology
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a triggered antimicrobial system based on different sulfoxide substrates and alliinase might be superior to the application of conventional fungicides or allicin itself
additional information
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general properties and evaluation of its application in on-site production of allicin-dependent fungicidal activity
additional information
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general properties and evaluation of its application in on-site production of allicin-dependent fungicidal activity
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