4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase

This is an abbreviated version!
For detailed information about 4-hydroxy-tetrahydrodipicolinate synthase, go to the full flat file.

Reaction

Synonyms

Aq_1143, AT2G45440, BA3935 gene product, cDHDPS, CjDHDPS, DapA, DapA2, DHDPA synthase, DHDPS, DHDPS2, dihydro-dipicolinic acid synthase, dihydrodipicolinate synthase, dihydrodipicolinic acid synthase, dihydrodipocolinate synthase, dihydropicolinate synthetase, EC 4.2.1.52, FaDHDPS, HTPA synthase, More, MosA, MosA protein, MRSA-DHDPS, PA1010, pyruvate-aspartic semialdehyde condensing enzyme, Rv2753c, synthase, dihydrodipicolinate, VEG81, Vegetative protein 81

ECTree

     4 Lyases

         4.3 Carbon-nitrogen lyases

             4.3.3 Amine-lyases

                4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase

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Results	in table
10	Activating Compound
50367	AA Sequence
34	Application
1	CAS Registry Number
67	Cloned(Commentary)
3	Cofactor
52	Crystallization (Commentary)
1	Expression
51	General Information
6	General Stability
13	IC50 Value
219	Inhibitors
28	kcat/KM [mM/s]
53	Ki Value [mM]
140	KM Value [mM]
6	Localization
1	Metals/Ions
46	Molecular Weight [Da]
53	Natural Substrates/ Products (Substrates)
257	Organism
12	Pathway
375	PDB ID
23	pH Optimum
1	pH Range
2	pH Stability
1	pI Value
60	Protein Variants
62	Purification (Commentary)
12	Reaction
1	Reaction Type
157	Reference
32	Source Tissue
46	Specific Activity [micromol/min/mg]
13	Storage Stability
153	Substrates and Products (Substrate)
57	Subunits
207	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
1	Temperature Range [°C]
15	Temperature Stability [°C]
73	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.3.3.7 - 4-hydroxy-tetrahydrodipicolinate synthase

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SYSTEMATIC NAME

IUBMB Comments

L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate-forming]

The reaction can be divided into three consecutive steps: Schiff base formation with pyruvate, the addition of L-aspartate-semialdehyde, and finally transimination leading to cyclization with simultaneous dissociation of the product. The product of the enzyme was initially thought to be (S)-2,3-dihydrodipicolinate [1,2], and the enzyme was classified accordingly as EC 4.2.1.52, dihydrodipicolinate synthase. Later studies of the enzyme from the bacterium Escherichia coli have suggested that the actual product of the enzyme is (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate [3], and thus the enzyme has been reclassified as 4-hydroxy-tetrahydrodipicolinate synthase. However, the identity of the product is still controversial, as more recently it has been suggested that it may be (S)-2,3-dihydrodipicolinate after all [5].