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4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase

This is an abbreviated version!
For detailed information about 4-hydroxy-tetrahydrodipicolinate synthase, go to the full flat file.

Word Map on EC 4.3.3.7

Reaction

pyruvate
+
L-aspartate-4-semialdehyde
=
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate
 +
H2O

Synonyms

Aq_1143, AT2G45440, BA3935 gene product, cDHDPS, CjDHDPS, DapA, DapA2, DHDPA synthase, DHDPS, DHDPS2, dihydro-dipicolinic acid synthase, dihydrodipicolinate synthase, dihydrodipicolinic acid synthase, dihydrodipocolinate synthase, dihydropicolinate synthetase, EC 4.2.1.52, FaDHDPS, HTPA synthase, More, MosA, MosA protein, MRSA-DHDPS, PA1010, pyruvate-aspartic semialdehyde condensing enzyme, Rv2753c, synthase, dihydrodipicolinate, VEG81, Vegetative protein 81

ECTree

     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.3 Amine-lyases
                4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase

KI Value

KI Value on EC 4.3.3.7 - 4-hydroxy-tetrahydrodipicolinate synthase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
32.4
(2E)-4-oxohept-2-enedioic acid
mono-ene inhibitor
1.63
(2E,5E)-4-oxohepta-2,5-dienedioic acid
more potent than the corresponding mono-ene inhibitors
0.07
(S)-aspartate 4-semialdehyde
substrate inhibition
0.15
(S)-aspartate-4-semialdehyde
pH and temperature not specified in the publication
0.32 - 3.9
(S)-Lys
0.32 - 4.7
(S)-lysine
0.29
2,2'-(2-hydroxy-1,3-phenylene)bis(2-oxoacetic acid)
-
pH 8.0, 30°C
2.96
2,2'-benzene-1,3-diylbis(oxoacetic acid)
0.021
2-oxopimelate
pH 7.4, 37°C
0.17
2-oxopimelic acid
in 50 mM Tris-HCl (pH 8.2), at 22°C
0.21
3-hydroxy-2-oxopropanoate
time-dependent inhibition, value similar to that of (S)-lysine
22 - 24.8
4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid
0.0002
bislysine
-
pH 8.0, 25°C
10.9
diethyl (2E)-4-oxohept-2-enedioate
mono-ene inhibitor
4.95
diethyl (2E,5E)-4-oxohepta-2,5-dienedioate
best inhibitor
0.33
dimethyl 2,2'-benzene-1,3-diylbis[(hydroxyimino)ethanoate]
15% inhibition at 1 mM, binding with the active site lysine residue, kinetic analysis corresponds to slow-binding model of inhibition
6.9 - 14
dimethyl chelidamate
0.33
dimethyl-(2E,2'E)-2,2'-benzene-1,3-diylbis[(hydroxyimino)ethanoate]
-
pH 8.0, 30°C
0.04
dimethyl-2,2'-(2-hydroxy-1,3-phenylene)bis(2-oxoacetate)
-
pH 8.0, 30°C
1 - 1.2
dipicolinic acid
0.8
dipicolinic acid N-oxide
-
-
5.4
L-aspartate 4-semialdehyde
Q81WN7
-
0.049 - 4.1
L-lysine
0.12 - 0.23
lysine
0.19 - 0.57
pyruvate
pH and temperature not specified in the publication
4.6
S-(2-aminoethyl)-L-cysteine
-
-
0.3
Succinate-semialdehyde
in 50 mM Tris-HCl (pH 8.2), at 22°C
additional information
additional information
-