4.3.2.2: adenylosuccinate lyase
This is an abbreviated version!
For detailed information about adenylosuccinate lyase, go to the full flat file.
Word Map on EC 4.3.2.2
-
4.3.2.2
-
purine
-
saicar
-
succinyladenosine
-
autistic
-
carboxamide
-
psychomotor
-
imp
-
succinylaminoimidazole
-
amylosucrase
-
ribotide
-
geothermalis
-
aminoimidazole
-
drug development
-
medicine
- 4.3.2.2
- purine
-
saicar
-
succinyladenosine
-
autistic
- carboxamide
-
psychomotor
- imp
-
succinylaminoimidazole
- amylosucrase
- ribotide
- geothermalis
-
aminoimidazole
- drug development
- medicine
Reaction
Synonyms
adenylosuccinase, adenylosuccinate lyase, ADL, ADSL, AMPS lyase, ASASE, ASL, Glutamyl-tRNA synthetase regulatory factor, lyase, adenylosuccinate, PurB, succino AMP-lyase, succino-AMP lyase
ECTree
4.3.2.2 adenylosuccinate lyaseAdvanced search results
results (
results (Reference
top
Reference on EC 4.3.2.2 - adenylosuccinate lyase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ebbole, D.J.; Zalkin, H.
Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis
J. Biol. Chem.
262
8274-8287
1987
Bacillus subtilis
Porter, D.J.T.; Rudie, N.G.; Bright, H.J.
Nitro analogs of substrates for adenylosuccinate synthetase and adenylosuccinate lyase
Arch. Biochem. Biophys.
225
157-163
1983
Saccharomyces cerevisiae
Spector, T.; Jones, T.E.; Elion, G.B.
Specificity of adenylosuccinate synthetase and adenylosuccinate lyase from Leishmania donovani. Selective amination of an antiprotozoal agent
J. Biol. Chem.
254
8422-8426
1979
Leishmania donovani
Casey, P.J.; Lowenstein, J.M.
Purification of adenylosuccinate lyase from rat skeletal muscle by a novel affinity column. Stabilization of the enzyme, and effects of anions and fluoro analogues of the substrate
Biochem. J.
246
263-269
1987
Rattus norvegicus
Casey, P.J.; Abeles, R.H.; Lowenstein, J.M.
Metabolism of threo-beta-fluoroaspartate by H4 cells. Inhibition of adenylosuccinate lyase by fluoro analogs of its substrates
J. Biol. Chem.
261
13637-13642
1986
Rattus norvegicus
Pinto, R.M.; Faraldo, A.; Fernandez, A.; Canales, J.; Sillero, A.; Sillero, M.A.G.
Adenylosuccinate lyase from Artemia embryos. Purification and properties
J. Biol. Chem.
258
12513-12519
1983
Artemia sp.
Woodward, D.O.
Adenylosuccinate AMP-lyase (Neurospora crassa)
Methods Enzymol.
11
202-207
1978
Neurospora crassa
Brand, L.M.; Lowenstein, J.M.
Effect of diet on adenylosuccinase activity in various organs of rat and chicken
J. Biol. Chem.
253
6872-6878
1978
Gallus gallus, Rattus norvegicus
Brand, L.M.; Lowenstein, J.M.
Inhibition of adenylosuccinase by adenylophosphonopropionate and related compounds
Biochemistry
17
1365-1370
1978
Rattus norvegicus
Spector, T.
Mammalian adenylosuccinate lyase. Participation in the conversion of 2 -dIMP and beta-D-arabinosyl-IMP to adenine nucleotides
Biochim. Biophys. Acta
481
741-745
1977
Mus musculus, Rattus norvegicus
Carter, C.E.; Cohen, L.H.
The preparation and properties of adenylosuccinase and adenylosuccinic acid
J. Biol. Chem.
222
17-30
1956
Saccharomyces cerevisiae
Mashall, V.M.; Coppel, R.L.
Characterisation of the gene encoding adenylosuccinate lyase of Plasmodium falciparum
Mol. Biochem. Parasitol.
88
237-241
1997
Plasmodium falciparum
Redinbo, M.R.; Eide, S.M.; Stone, R.L.; Dixon, J.E.; Yeates, T.O.
Crystallization and preliminary structural analysis of Bacillus subtilis adenylosuccinate lyase, an enzyme implicated in infantile autism
Protein Sci.
5
786-788
1996
Bacillus subtilis
Stone, R.L.; Zalkin, H.; Dixon, J.E.
Expression, purification, and kinetic characterization of recombinant human adenylosuccinate lyase
J. Biol. Chem.
268
19710-19716
1993
Homo sapiens
Barshop, B.A.; Alberts, A.S.; Gruber, H.E.
Kinetic studies of mutant human adenylosuccinase
Biochim. Biophys. Acta
999
19-23
1989
Homo sapiens
Hartgers, W.A.; de Boer, R.F.; Wanner, M.J.; Koomen, G.J.
A potential suicide inhibitor of adenylosuccinate lyase
Nucleosides Nucleotides
11
1325-1332
1992
Saccharomyces cerevisiae
-
Nair, V.; Sells, T.B.
Interpretation of the roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2 ,3 -dideoxyadenosine and 2 ,3 -dideoxyinosine
Biochim. Biophys. Acta
1119
201-204
1992
Saccharomyces cerevisiae
Crifo, C.; Lomonte, A.; Salerno, C.
Inhibition of adenylosuccinate lyase by 2,3 -acyclic substrate analogs
Adv. Exp. Med. Biol.
431
245-248
1998
Homo sapiens
Van den Bergh, F.; Vincent, M.F.; Jaeken, J.; van den Berghe, G.
Radiochemical assay of adenylosuccinase: demonstration of parallel loss of activity toward both adenylosuccinate and succinylaminoimidazole carboxamide ribotide in liver of patients with the enzyme defect
Anal. Biochem.
193
287-291
1991
Homo sapiens
Shaw, G.; Thomas, P.S.; Patey, C.A.H.; Thomas, S.E.
Purines, pyrimidines, and imidazoles. Part 50. Inhibition and adenylosuccinate AMP-lyase No. 4.3.2.2. by derivatives of N-(5-amino-1-beta-D-ribofuranosylimidazole-4-carbonyl)-L-aspartic acid 5'-phosphate (SAICAR) and virazole 5'-phosphate
J. Chem. Soc. Perkin Trans.
1
1415-1424
1979
Saccharomyces cerevisiae
-
Stone, R.L.; Aimi, J.; Barshop, B.A.; Jaeken, J.; van den Berghe, G.; Zalkin, H.; Dixon, J.E.
A mutation in adenylosuccinate lyase associated with mental retardation and autistic features
Nature Genet.
1
59-63
1992
Homo sapiens
Segall, M.L.; Colman, R.F.
Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis
Biochemistry
43
7391-7402
2004
Bacillus subtilis
Crifo, C.; Siems, W.; Soro, S.; Salerno, C.
Inhibition of defective adenylosuccinate lyase by HNE: a neurological disease that may be affected by oxidative stress
Biofactors
24
131-136
2005
Bacillus subtilis, Homo sapiens, Pyrobaculum aerophilum, Thermotoga maritima
Sivendran, S.; Patterson, D.; Spiegel, E.; McGown, I.; Cowley, D.; Colman, R.F.
Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL
J. Biol. Chem.
279
53789-53797
2004
Bacillus subtilis, Homo sapiens
Tsai, M.; Koo, J.; Yip, P.; Colman, R.F.; Segall, M.L.; Howell, P.L.
Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism
J. Mol. Biol.
370
541-554
2007
Escherichia coli (P0AB89), Escherichia coli
Spiegel, E.K.; Colman, R.F.; Patterson, D.
Adenylosuccinate lyase deficiency
Mol. Genet. Metab.
89
19-31
2006
Bacillus subtilis, Homo sapiens, Mus musculus, Pyrobaculum aerophilum, Thermotoga maritima (Q9X0I0)
Lee, P.; Colman, R.F.
Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase
Protein Expr. Purif.
51
227-234
2007
Homo sapiens
Sivendran, S.; Segall, M.L.; Rancy, P.C.; Colman, R.F.
Effect of Asp69 and Arg310 on the pK of His68, a key catalytic residue of adenylosuccinate lyase
Protein Sci.
16
1700-1707
2007
Bacillus subtilis
Segall, M.L.; Cashman, M.A.; Colman, R.F.
Important roles of hydroxylic amino acid residues in the function of Bacillus subtilis adenylosuccinate lyase
Protein Sci.
16
441-448
2007
Bacillus subtilis
De Zoysa Ariyananda, L.; Colman, R.F.
Evaluation of types of interactions in subunit association in Bacillus subtilis adenylosuccinate lyase
Biochemistry
47
2923-2934
2008
Bacillus subtilis (P12047), Bacillus subtilis
Bulusu, V.; Srinivasan, B.; Bopanna, M.P.; Balaram, H.
Elucidation of the substrate specificity, kinetic and catalytic mechanism of adenylosuccinate lyase from Plasmodium falciparum
Biochim. Biophys. Acta
1794
642-654
2008
Plasmodium falciparum (O15918), Plasmodium falciparum
Gitiaux, C.; Ceballos-Picot, I.; Marie, S.; Valayannopoulos, V.; Rio, M.; Verrieres, S.; Benoist, J.F.; Vincent, M.F.; Desguerre, I.; Bahi-Buisson, N.
Misleading behavioural phenotype with adenylosuccinate lyase deficiency
Eur. J. Hum. Genet.
17
133-136
2009
Homo sapiens (P30566), Homo sapiens
Lopez, J.M.
Is ZMP the toxic metabolite in Lesch-Nyhan disease?
Med. Hypotheses
71
657-663
2008
Homo sapiens
Jurecka, A.; Zikanova, M.; Tylki-Szymanska, A.; Krijt, J.; Bogdanska, A; Gradowska, W.; Mullerova, K.; Sykut-Cegielska, J.; Kmoch, S.; Pronicka, E.
Clinical, biochemical and molecular findings in seven Polish patients with adenylosuccinate lyase deficiency
Mol. Genet. Metab.
94
435-442
2008
Homo sapiens
Sivendran, S.; Colman, R.F.
Effect of a new non-cleavable substrate analog on wild-type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens
Protein Sci.
17
1162-1174
2008
Bacillus subtilis, Homo sapiens (P30566), Homo sapiens
Jurecka, A.; Tylki-Szymanska, A.; Zikanova, M.; Krijt, J.; Kmoch, S.
D-Ribose therapy in four Polish patients with adenylosuccinate lyase deficiency: absence of positive effect
J. Inherit. Metab. Dis.
31
S329-332
2008
Homo sapiens
Kozlov, G.; Nguyen, L.; Pearsall, J.; Gehring, K.
The structure of phosphate-bound Escherichia coli adenylosuccinate lyase identifies His171 as a catalytic acid
Acta Crystallogr. Sect. F
65
857-861
2009
Escherichia coli (Q8X737), Escherichia coli
Ariyananda, L.d.e..Z.; Lee, P.; Antonopoulos, C.; Colman, R.F.
Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants
Biochemistry
48
5291-5302
2009
Homo sapiens (P30566), Homo sapiens
Mierzewska, H.; Schmidt-Sidor, B.; Jurkiewicz, E.; Bogdanska, A.; Kusmierska, K.; Stepien, T.
Severe encephalopathy with brain atrophy and hypomyelination due to adenylosuccinate lyase deficiency--MRI, clinical, biochemical and neuropathological findings of Polish patients
Folia Neuropathol.
47
314-320
2009
Homo sapiens
Zikanova, M.; Skopova, V.; Hnizda, A.; Krijt, J.; Kmoch, S.
Biochemical and structural analysis of 14 mutant ADSL enzyme complexes and correlation to phenotypic heterogeneity of adenylosuccinate lyase deficiency
Hum. Mutat.
31
445-455
2010
Homo sapiens (P30566), Homo sapiens
Chen, B.C.; McGown, I.N.; Thong, M.K.; Pitt, J.; Yunus, Z.M.; Khoo, T.B.; Ngu, L.H.; Duley, J.A.
Adenylosuccinate lyase deficiency in a Malaysian patient, with novel adenylosuccinate lyase gene mutations
J. Inherit. Metab. Dis.
33
S159-162
2010
Homo sapiens
Chauhan, P.S.; Nautiyal, C.S.
The purB gene controls rhizosphere colonization by Pantoea agglomerans
Lett. Appl. Microbiol.
50
205-210
2010
Pantoea agglomerans
Camici, M.; Micheli, V.; Ipata, P.L.; Tozzi, M.G.
Pediatric neurological syndromes and inborn errors of purine metabolism
Neurochem. Int.
56
367-378
2010
Homo sapiens
Henneke, M.; Dreha-Kulaczewski, S.; Brockmann, K.; van der Graaf, M.; Willemsen, M.A.; Engelke, U.; Dechent, P.; Heerschap, A.; Helms, G.; Wevers, R.A.; Gaertner, J.
In vivo proton MR spectroscopy findings specific for adenylosuccinate lyase deficiency
NMR Biomed.
23
441-445
2010
Homo sapiens
Fyfe, P.K.; Dawson, A.; Hutchison, M.T.; Cameron, S.; Hunter, W.N.
Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery
Acta Crystallogr. Sect. D
66
881-888
2010
Staphylococcus aureus (Q7A0G9), Staphylococcus aureus
De Zoysa Ariyananda, L.; Antonopoulos, C.; Currier, J.; Colman, R.F.
In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes
Biochemistry
50
1336-1346
2011
Homo sapiens
Yuan, T.; Gu, J.R.; Gu, W.B.; Wu, J.; Ge, S.R.; Xu, H.
Molecular cloning, characterization and expression analysis of adenylosuccinate lyase gene in grass carp (Ctenopharyngodon idella)
Mol. Biol. Rep.
38
2059-2065
2011
Ctenopharyngodon idella (B2LS18), Ctenopharyngodon idella
Toth, E.A.; Worby, C.; Dixon, J.E.; Goedken, E.R.; Marqusee, S.; Yeates, T.O.
The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds
J. Mol. Biol.
301
433-450
2000
Pyrobaculum aerophilum (Q8ZY28), Pyrobaculum aerophilum, Pyrobaculum aerophilum DSM 7523 (Q8ZY28)
Ray, S.P.; Deaton, M.K.; Capodagli, G.C.; Calkins, L.A.; Sawle, L.; Ghosh, K.; Patterson, D.; Pegan, S.D.
Structural and biochemical characterization of human adenylosuccinate lyase (ADSL) and the R303C ADSL deficiency-associated mutation
Biochemistry
51
6701-6713
2012
Homo sapiens (P30566), Homo sapiens
Ray, S.P.; Duval, N.; Wilkinson, T.G.; Shaheen, S.E.; Ghosh, K.; Patterson, D.
Inherent properties of adenylosuccinate lyase could explain S-Ado/SAICAr ratio due to homozygous R426H and R303C mutations
Biochim. Biophys. Acta
1834
1545-1553
2013
Homo sapiens
Banerjee, S.; Agrawal, M.J.; Mishra, D.; Sharan, S.; Balaram, H.; Savithri, H.S.; Murthy, M.R.
Structural and kinetic studies on adenylosuccinate lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme
FEBS J.
281
1642-1658
2014
Mycobacterium tuberculosis, Mycolicibacterium smegmatis (A0R4I6)
Bierau, J.; Pooters, I.N.; Visser, D.; Bakker, J.A.
An HPLC-based assay of adenylosuccinate lyase in erythrocytes
Nucleosides Nucleotides Nucleic Acids
30
908-917
2011
Homo sapiens
Stuer-Lauridsen, B.; Nygaard, P.
Purine salvage in two halophilic archaea: characterization of salvage pathways and isolation of mutants resistant to purine analogs
J. Bacteriol.
180
457-463
1998
Halobacterium salinarum, Haloferax volcanii
Gooding, J.R.; Jensen, M.V.; Dai, X.; Wenner, B.R.; Lu, D.; Arumugam, R.; Ferdaoussi, M.; MacDonald, P.E.; Newgard, C.B.
Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism
Cell Rep.
13
157-167
2015
Rattus norvegicus (D3ZW08)
Galina, L.; Dalberto, P.; Martinelli, L.; Roth, C.; Pinto, A.; Villela, A.; Bizarro, C.; MacHado, P.; Timmers, L.; De Souza, O.; De Carvalho Filho, E.; Basso, L.; Santos, D.
Biochemical, thermodynamic and structural studies of recombinant homotetrameric adenylosuccinate lyase from Leishmania braziliensis
RSC Adv.
7
54347-54360
2017
Leishmania braziliensis (A4H3W5)
-
html completed
