4.2.3.5: chorismate synthase
This is an abbreviated version!
For detailed information about chorismate synthase, go to the full flat file.
Word Map on EC 4.2.3.5
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4.2.3.5
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flavin
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dahps
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7-phosphate
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3-deoxy-d-arabino-heptulosonate
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sempervirens
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dehydroquinate
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corydalis
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drug development
- 4.2.3.5
- flavin
- dahps
- 7-phosphate
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3-deoxy-d-arabino-heptulosonate
- sempervirens
- dehydroquinate
- corydalis
- drug development
Reaction
Synonyms
5-enolpyruvylshikimate-3-phosphate phospholyase, 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate lyase, ARO2, aroC, aroF, chorismate synthase, chorismate synthetase, CS, CS1, CS2, EC 4.6.1.4, MtCS, VEG216, Vegetative protein 216, Vlaro2
ECTree
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Specific Activity
Specific Activity on EC 4.2.3.5 - chorismate synthase
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additional information
additional information
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bifunctionality is determined by measurements of both chorismate synthase and NADH:FMN oxidoreductase activities
additional information
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in the presence of oxygen the CS activity is limited by the reoxidation of FMNred cofactor
additional information
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activity of mutant S127A is 6fold lower than that of the wild-type protein
additional information
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activity of mutant S16A is 70fold lower than that of the wild-type protein
additional information
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chorismate synthase has an intrinsic NADPH: FMN oxidoreductase activity that enables the enzyme to generate the reduced FMN cofactor (bifunctionality)
additional information
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no activity of double-mutant protein S16A/S127A, replacement of both serine residues produces a synergistic effect