4.2.3.4: 3-dehydroquinate synthase

This is an abbreviated version!
For detailed information about 3-dehydroquinate synthase, go to the full flat file.

Reaction

Synonyms

3-dehydroquinate synthase, 3-dehydroquinate synthetase, 3-dehydroquinic acid synthetase, 5-dehydroquinate synthase, 5-dehydroquinic acid synthetase, aroB, dehydroquinate synthase, dehydroquinate synthetase, DHQ synthase, DHQS, EC 4.6.1.3, hpDHQS, synthase, 5-dehydroquinate, Xoo1243

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.4 3-dehydroquinate synthase

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Results	in table
1	Activating Compound
35355	AA Sequence
4	Application
1	CAS Registry Number
20	Cloned(Commentary)
26	Cofactor
10	Crystallization (Commentary)
1	General Information
1	General Stability
3	IC50 Value
65	Inhibitors
11	kcat/KM [mM/s]
3	Ki Value [mM]
27	KM Value [mM]
1	Localization
35	Metals/Ions
47	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
81	Organism
6	Pathway
69	PDB ID
6	pH Optimum
2	pH Range
17	Purification (Commentary)
3	Reaction
10	Reaction Type
69	Reference
6	Source Tissue
34	Specific Activity [micromol/min/mg]
6	Storage Stability
42	Substrates and Products (Substrate)
15	Subunits
43	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
15	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.2.3.4 - 3-dehydroquinate synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate

(6R)-6-fluoro-dehydroquinate

3 entries

(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate

(6S)-6-fluoro-dehydroquinate + 1-epi-(6S)-6-fluoro-dehydroquinate

3 entries

3-deoxy-arabino-heptulonate 7-phosphate

3-dehydroquinate + phosphate

Aspergillus nidulans

-

-

666849

-

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

13 entries

3-deoxy-D-arabino-heptulosonate 7-phosphate

3-dehydroquinate + phosphate

2 entries

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

3-dehydroquinate + phosphate

6 entries

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

?

3 entries

3-deoxy-D-arabinoheptulosonate 7-phosphate

3-dehydroquinate + phosphate

Xanthomonas oryzae

-

shikimate pathway is present in all organisms except mammals

690254

-

-

?

7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate

3-dehydroquinate + phosphate

3 entries

additional information

?

-

Xanthomonas oryzae

-

enzyme plays an essential role in the synthesis of aromatic compounds in the shikimate pathway

690254

-

-

?

(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate

(6R)-6-fluoro-dehydroquinate

Actinidia chinensis

-

-

716413

-

-

?

(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate

(6R)-6-fluoro-dehydroquinate

Escherichia coli

-

-

716413

-

-

?

(3R)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate

(6R)-6-fluoro-dehydroquinate

Pyrococcus furiosus

-

-

716413

-

-

?

(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate

(6S)-6-fluoro-dehydroquinate + 1-epi-(6S)-6-fluoro-dehydroquinate

Actinidia chinensis

-

-

716413

1-epi-(6S)-6-fluoro-dehydroquinate formation occurs by an unusual partial leakage of a reaction intermediate from the enzyme

-

?

(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate

(6S)-6-fluoro-dehydroquinate + 1-epi-(6S)-6-fluoro-dehydroquinate

Escherichia coli

-

-

716413

1-epi-(6S)-6-fluoro-dehydroquinate formation occurs by an unusual partial leakage of a reaction intermediate from the enzyme

-

?

(3S)-3-fluoro-3-deoxy-D-arabino-heptulosonate 7-phosphate

(6S)-6-fluoro-dehydroquinate + 1-epi-(6S)-6-fluoro-dehydroquinate

Pyrococcus furiosus

-

-

716413

1-epi-(6S)-6-fluoro-dehydroquinate formation occurs by an unusual partial leakage of a reaction intermediate from the enzyme

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Actinidia chinensis

-

-

716413, 729105

-

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Aspergillus nidulans

-

-

137641

-

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Bacillus subtilis

-

-

137636

-

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Escherichia coli

-

-

716413, 718818, 718819

-

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Escherichia coli

P07639

-

680370

-

-

ir

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Escherichia coli RB791

-

-

718818, 718819

-

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Mycobacterium tuberculosis

P9WPX9

-

748438

-

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Mycobacterium tuberculosis

P9WPX9

-

680499

-

-

ir

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Mycobacterium tuberculosis H37Rv

P9WPX9

-

680499

-

-

ir

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Mycobacterium tuberculosis H37Rv

P9WPX9

-

748438

-

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Pyrococcus furiosus

-

-

716413

-

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Pyrococcus furiosus

Q8U0A8

-

722147

-

-

?

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

Pyrococcus furiosus

Q8U0A8

the enzyme catalyses the second step of the shikimate pathway to aromatic compounds

722147

-

-

?

3-deoxy-D-arabino-heptulosonate 7-phosphate

3-dehydroquinate + phosphate

Aspergillus nidulans

-

-

666849

-

-

?

3-deoxy-D-arabino-heptulosonate 7-phosphate

3-dehydroquinate + phosphate

Helicobacter pylori

P56081

second key step in the shikimate pathway which is crucial for the aromatic amino acid metabolism in bacteria, fungi, and plants, but not in mammals

690739

-

-

?

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

3-dehydroquinate + phosphate

Escherichia coli

-

-

137619

-

137619

ir

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

3-dehydroquinate + phosphate

Escherichia coli

-

-

137623

-

137623

ir

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

3-dehydroquinate + phosphate

Escherichia coli

-

-

137624

-

137624

ir

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

3-dehydroquinate + phosphate

Neurospora crassa

-

-

137624

-

137624

?

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

3-dehydroquinate + phosphate

Neurospora crassa

-

-

137628

-

137628

?

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

3-dehydroquinate + phosphate

Neurospora crassa 74-OR23-1A

-

-

137628

-

137628

?

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

?

Escherichia coli

-

-

137619, 137623, 137624

-

-

?

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

?

Neurospora crassa

-

-

137624

-

-

?

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

?

Pisum sativum

-

-

137620

-

-

?

7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate

3-dehydroquinate + phosphate

Providencia alcalifaciens

X6Q997

-

763209

-

-

?

7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate

3-dehydroquinate + phosphate

Providencia alcalifaciens F90-2004

X6Q997

-

763209

-

-

?

7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate

3-dehydroquinate + phosphate

Trichormus variabilis

Q3M4V2

-

763080

-

-

?