4.2.3.4: 3-dehydroquinate synthase

This is an abbreviated version!
For detailed information about 3-dehydroquinate synthase, go to the full flat file.

Word Map on EC 4.2.3.4

4.2.3.4

shikimate

dahp

3-deoxy-d-arabino-heptulosonate

chorismate

pentafunctional

3-phosphoshikimate

3-dehydroquinase

1-carboxyvinyltransferase

drug development

medicine

Reaction

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

Synonyms

3-dehydroquinate synthase, 3-dehydroquinate synthetase, 3-dehydroquinic acid synthetase, 5-dehydroquinate synthase, 5-dehydroquinic acid synthetase, aroB, dehydroquinate synthase, dehydroquinate synthetase, DHQ synthase, DHQS, EC 4.6.1.3, hpDHQS, synthase, 5-dehydroquinate, Xoo1243

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.4 3-dehydroquinate synthase

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Results	in table
1	Activating Compound
35355	AA Sequence
4	Application
1	CAS Registry Number
20	Cloned(Commentary)
26	Cofactor
10	Crystallization (Commentary)
1	General Information
1	General Stability
3	IC50 Value
65	Inhibitors
11	kcat/KM [mM/s]
3	Ki Value [mM]
27	KM Value [mM]
1	Localization
35	Metals/Ions
47	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
81	Organism
6	Pathway
69	PDB ID
6	pH Optimum
2	pH Range
17	Purification (Commentary)
3	Reaction
10	Reaction Type
69	Reference
6	Source Tissue
34	Specific Activity [micromol/min/mg]
6	Storage Stability
42	Substrates and Products (Substrate)
15	Subunits
43	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
15	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 4.2.3.4 - 3-dehydroquinate synthase

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3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate

3-dehydroquinate + phosphate

6 entries

3-deoxy-D-arabino-heptulosonate 7-phosphate

3-dehydroquinate + phosphate

Helicobacter pylori

P56081

second key step in the shikimate pathway which is crucial for the aromatic amino acid metabolism in bacteria, fungi, and plants, but not in mammals

690739

3-deoxy-D-arabino-heptulosonic acid 7-phosphate

3 entries

3-deoxy-D-arabinoheptulosonate 7-phosphate

3-dehydroquinate + phosphate

Xanthomonas oryzae

shikimate pathway is present in all organisms except mammals

690254

additional information

Xanthomonas oryzae

enzyme plays an essential role in the synthesis of aromatic compounds in the shikimate pathway

690254