4.2.3.4: 3-dehydroquinate synthase
This is an abbreviated version!
For detailed information about 3-dehydroquinate synthase, go to the full flat file.
Word Map on EC 4.2.3.4
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4.2.3.4
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shikimate
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dahp
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3-deoxy-d-arabino-heptulosonate
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chorismate
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pentafunctional
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3-phosphoshikimate
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3-dehydroquinase
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1-carboxyvinyltransferase
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drug development
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medicine
- 4.2.3.4
- shikimate
- dahp
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3-deoxy-d-arabino-heptulosonate
- chorismate
-
pentafunctional
- 3-phosphoshikimate
- 3-dehydroquinase
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1-carboxyvinyltransferase
- drug development
- medicine
Reaction
Synonyms
3-dehydroquinate synthase, 3-dehydroquinate synthetase, 3-dehydroquinic acid synthetase, 5-dehydroquinate synthase, 5-dehydroquinic acid synthetase, aroB, dehydroquinate synthase, dehydroquinate synthetase, DHQ synthase, DHQS, EC 4.6.1.3, hpDHQS, synthase, 5-dehydroquinate, Xoo1243
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Metals Ions
Metals Ions on EC 4.2.3.4 - 3-dehydroquinate synthase
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Cd2+
Co2+
Cu2+
Mg2+
X6Q997
In the DHQS-NAD complex structure, Mg2+ shows octahedral coordination geometry, and Mg2+ coordinates with residues His248 and His265, Glu184 and three water molecules
Mn2+
Ni2+
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reconstitution of the apoenzyme with Ni2+ restores activity to 23% of the level observed with the Co2+-holoenzyme
Zn2+
additional information
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reconstitution of the apoenzyme with Cd2+ restores activity to12% of the level observed with the Co2+-holoenzyme
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reconstitution of the apoenzyme with Zn2+ restores activity to 9% of the level observed with the Co2+-holoenzyme
Mn2+
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reconstitution of the apoenzyme with Mn2+ restores activity to 10% of the level observed with the Co2+-holoenzyme
Zn2+
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reconstitution of the apoenzyme with Zn2+ restores activity to 53% of the level observed with the Co2+-holoenzyme
additional information
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no activity in the presence of Mg2+, Ca2+, Sr2+, and Ba2+