4.2.3.1: threonine synthase
This is an abbreviated version!
For detailed information about threonine synthase, go to the full flat file.
Word Map on EC 4.2.3.1
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4.2.3.1
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cystathionine
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gamma-synthase
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o-phosphohomoserine
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plp-dependent
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aspartate-derived
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rhizocticins
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lactofermentum
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aldimine
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agriculture
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medicine
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nutrition
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analysis
- 4.2.3.1
- cystathionine
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gamma-synthase
- o-phosphohomoserine
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plp-dependent
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aspartate-derived
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rhizocticins
- lactofermentum
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aldimine
- agriculture
- medicine
- nutrition
- analysis
Reaction
Synonyms
EC 4.2.99.2, MtTS, synthase, threonine, THR4, threonine synthase, threonine synthase (gene MA1610), threonine synthetase, ThrS, TS
ECTree
4.2.3.1 threonine synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.3.1 - threonine synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
phosphohomoserine
2-oxobutyrate + phosphate + ?
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bypass of threonine in isoleucine biosynthesis
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ir
L-vinylglycine + phosphate + H2O
L-threonine + phosphate
in the presence of phosphate, L-threonine is formed with kcat and reaction specificity comparable with those when O-phospho-L-homoserine is used as the substrate. In the absence of phosphate or when sulfate is used in place of phosphate, only the side reaction product, alpha-ketobutyrate, is formed. Compared with the more acidic sulfate ion, the phosphate ion decreases the energy levels of the transition states of the addition of water at the Cbeta of the PLP-alpha-aminocrotonate aldimine and the transaldimination to form L-threonine. Threonine synthase is in the closed form, when the substrate and the intermediates are bound to the enzyme
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-
?
L-vinylglycine + phosphate + H2O
L-threonine + phosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
in the presence of phosphate, L-threonine is formed with kcat and reaction specificity comparable with those when O-phospho-L-homoserine is used as the substrate. In the absence of phosphate or when sulfate is used in place of phosphate, only the side reaction product, alpha-ketobutyrate, is formed. Compared with the more acidic sulfate ion, the phosphate ion decreases the energy levels of the transition states of the addition of water at the Cbeta of the PLP-alpha-aminocrotonate aldimine and the transaldimination to form L-threonine. Threonine synthase is in the closed form, when the substrate and the intermediates are bound to the enzyme
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-
?
O-phospho-L-homoserine
?
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involved in allocation of phosphohomoserine between cystathione and threonine pathways
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-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
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threonine synthesis in eukaryotes
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-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
-
-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
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enzyme at the metabolic branch point between methionine and threonine biosynthesis
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?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
last reaction in the synthesis of threonine from aspartate
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?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
threonine synthesis in eukaryotes
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-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
-
-
-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
-
-
-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
-
-
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ir
O-phospho-L-homoserine + H2O
L-threonine + phosphate
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threonine synthesis in eukaryotes
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-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
-
-
-
-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
-
-
-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
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-
-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
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final step of threonine biosynthesis
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?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
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-
-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
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reaction is 99% specific for L-threonine formation. Minor product is 2-ketobutanoate
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?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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-
-
?
O-phospho-L-homoserine + H2O
L-threonine + phosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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reaction is 99% specific for L-threonine formation. Minor product is 2-ketobutanoate
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?
threonine
2-oxobutyrate + NH3
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genetic evidence for identity of protein with both activities
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ir
