4.2.3.1: threonine synthase
This is an abbreviated version!
For detailed information about threonine synthase, go to the full flat file.
Word Map on EC 4.2.3.1
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4.2.3.1
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cystathionine
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gamma-synthase
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o-phosphohomoserine
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plp-dependent
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aspartate-derived
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rhizocticins
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lactofermentum
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aldimine
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agriculture
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medicine
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nutrition
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analysis
- 4.2.3.1
- cystathionine
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gamma-synthase
- o-phosphohomoserine
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plp-dependent
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aspartate-derived
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rhizocticins
- lactofermentum
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aldimine
- agriculture
- medicine
- nutrition
- analysis
Reaction
Synonyms
EC 4.2.99.2, MtTS, synthase, threonine, THR4, threonine synthase, threonine synthase (gene MA1610), threonine synthetase, ThrS, TS
ECTree
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Reaction
Reaction on EC 4.2.3.1 - threonine synthase
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O-phospho-L-homoserine + H2O = L-threonine + phosphate
reaction proceeds via phospate removal and isomerization from primary to secondary alcohol
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O-phospho-L-homoserine + H2O = L-threonine + phosphate
mechanism of phosphohomoserine dephosphorylation/deamination activity
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O-phospho-L-homoserine + H2O = L-threonine + phosphate
inhibitor studies concerning mechanism, model of stepwise catalytic mechanism
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O-phospho-L-homoserine + H2O = L-threonine + phosphate
reaction proceeds via phosphate removal and isomerization from primary to secondary alcohol
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O-phospho-L-homoserine + H2O = L-threonine + phosphate
reaction proceeds via phosphate removal and isomerization from primary to secondary alcohol
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O-phospho-L-homoserine + H2O = L-threonine + phosphate
reaction proceeds via phosphate removal and isomerization from primary to secondary alcohol
O-phospho-L-homoserine + H2O = L-threonine + phosphate
analyzed crystal structure gives new insights into the catalytic mechanism of threonine synthase in general, specifically by suggesting the direct involvement of the phosphate moiety of the cofactor, rather than the inorganic phosphate product, in transferring a proton from C4 to Cgamma in the formation of the alphabeta-unsaturated aldimine
O-phospho-L-homoserine + H2O = L-threonine + phosphate
the phosphate ion released from O-phospho-L-homoserine by gamma-elimination acts as the base catalyst for the addition of water at Cbeta of the alpha-aminocrotonate aldimine, thereby providing the basis of the reaction specificity. The phosphate ion also accelerates the protonation/deprotonation at Cgamma
O-phospho-L-homoserine + H2O = L-threonine + phosphate
analyzed crystal structure gives new insights into the catalytic mechanism of threonine synthase in general, specifically by suggesting the direct involvement of the phosphate moiety of the cofactor, rather than the inorganic phosphate product, in transferring a proton from C4 to Cgamma in the formation of the alphabeta-unsaturated aldimine
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O-phospho-L-homoserine + H2O = L-threonine + phosphate
the phosphate ion released from O-phospho-L-homoserine by gamma-elimination acts as the base catalyst for the addition of water at Cbeta of the alpha-aminocrotonate aldimine, thereby providing the basis of the reaction specificity. The phosphate ion also accelerates the protonation/deprotonation at Cgamma
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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