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4.2.1.98: 16alpha-hydroxyprogesterone dehydratase

This is an abbreviated version!
For detailed information about 16alpha-hydroxyprogesterone dehydratase, go to the full flat file.

Reaction

16alpha-hydroxyprogesterone
=
16,17-didehydroprogesterone
+
H2O

Synonyms

16-dehydroprogesterone reductase, 16alpha-dehydroxylase, 16alpha-Hydroxyprogesterone dehydroxylase, Dehydroxylase, hydroxy steroid 16alpha, dehydroxylase, hydroxy steroid 16alpha-, EC 4.2.1.86, Hydroxyprogesterone dehydroxylase, reductase, 16-dehydroprogesterone

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.98 16alpha-hydroxyprogesterone dehydratase

Inhibitors

Inhibitors on EC 4.2.1.98 - 16alpha-hydroxyprogesterone dehydratase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
16-Ketoprogesterone
-
competitive with respect to 16alpha-hydroxypregnenolone and 16alpha-hydroxyprogesterone
16alpha-hydroxypregnenolone
-
substrate inhibition at high concentrations
butanol
-
-
cetyltrimethylammonium bromide
-
no inhibition by NaBr
HgCl2
-
0.1 mM, 87% inhibition
iodoacetic acid
-
slight
Isopropanol
-
-
n-butanol
-
-
n-Propanol
-
-
NEM
-
slight
PCMB
-
0.5 mM, 50% inhibition
Propanol
-
-
rifampicin
-
-
Rifampin
-
i.e. rifampicin
sulfhydryl reagent
-
-
-
sulfhydryl reagents
-
-
Tris-HCl
additional information
-
not inhibited by inhibitors of electron transport reactions or metal chelators
-