4.2.1.96: 4a-hydroxytetrahydrobiopterin dehydratase

This is an abbreviated version!
For detailed information about 4a-hydroxytetrahydrobiopterin dehydratase, go to the full flat file.

Reaction

Synonyms

4 alpha-Hydroxy-tetrahydropterin dehydratase, 4-alpha-hydroxy-tetrahydropterin dehydratase, 4-alpha-hydroxytetrahydrobiopterin dehydratase, 4a-Carbinolamine dehydratase, 4a-Hydroxytetrahydrobiopterin dehydratase, 4a-Hydroxytetrahydropterin dehydratase, carbinolamine-4a-dehydratase, cDcoH, DCoH, DCoH/PCD, DcoH2, DCoHalpha, Dehydratase, 4a-carbinolamine, Dimerization cofactor of hepatocyte nuclear factor 1-alpha, Dimerization cofactor of HNF1, Dimerization factor of HNF1/pterin-4alpha-carbinolamine dehydratase, GenBank AE000671-derived protein GI 2982796, More, P4aCD, PCD, PCD/DCoH, PCD/PhhB, PCDH, Phenylalanine hydroxylase-stimulating protein, Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase, PhhB, PHS, PHS/PCD, pterin 4a-carbinolamine dehydratase, Pterin carbinolamine dehydratase, Pterin-4 alpha-carbinolamine dehydratase, Pterin-4-alpha-carbinolamine dehydratase, Pterin-4a-carbinolamine dehydratase, Pterin-4a-carbinolamine dehydratase (Aquifex aeolicus gene phhB), Pterin-4a-carbinolamine dehydratase/dimerization cofactor of HNF1, Pterin-4alpha-carbinolamine dehydratase, Pterin-4alpha-carbinolamine dehydratase (PCD)/dimerization cofactor for the transcription factor HBF-1alpha, XDCoH

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.96 4a-hydroxytetrahydrobiopterin dehydratase

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Results	in table
1	Activating Compound
29794	AA Sequence
2	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
56	Disease/ Diagnostics
12	General Information
1	General Stability
5	Inhibitors
38	KM Value [mM]
11	Localization
1	Metals/Ions
15	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
34	Organism
6	Pathway
38	PDB ID
24	Protein Variants
11	Purification (Commentary)
4	Reaction
2	Reaction Type
34	Reference
1	Renatured (Commentary)
21	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
38	Substrates and Products (Substrate)
16	Subunits
61	Synonyms
1	Systematic Name
10	Turnover Number [1/s]

Synonyms

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Synonyms on EC 4.2.1.96 - 4a-hydroxytetrahydrobiopterin dehydratase

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4 alpha-Hydroxy-tetrahydropterin dehydratase

-

-

-

-

4-alpha-hydroxy-tetrahydropterin dehydratase

-

-

-

-

4-alpha-hydroxytetrahydrobiopterin dehydratase

Zea mays

B6TSX9

UniProt

748945

4a-Carbinolamine dehydratase

-

-

-

-

4a-Hydroxytetrahydrobiopterin dehydratase

2 entries

4a-Hydroxytetrahydropterin dehydratase

-

-

-

-

carbinolamine-4a-dehydratase

Homo sapiens

-

-

668883

cDcoH

-

-

-

-

DCoH

-

-

-

-

DCoH/PCD

-

-

-

-

DcoH2

Mus musculus

Q9CZL5

dimerization cofactor of HNF1alpha

661146

DCoHalpha

2 entries

Dehydratase, 4a-carbinolamine

-

-

-

-

Dimerization cofactor of hepatocyte nuclear factor 1-alpha

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-

-

-

Dimerization cofactor of HNF1

-

-

-

-

Dimerization factor of HNF1/pterin-4alpha-carbinolamine dehydratase

-

-

-

-

GenBank AE000671-derived protein GI 2982796

-

-

-

-

P4aCD

-

-

-

-

PCD

9 entries

PCD/DCoH

2 entries

PCD/PhhB

-

-

-

-

PCDH

-

-

-

-

Phenylalanine hydroxylase-stimulating protein

-

-

-

-

Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase

-

-

-

-

PhhB

Pseudomonas aeruginosa

-

-

661990, 704330

PHS

-

-

-

-

PHS/PCD

-

-

-

-

pterin 4a-carbinolamine dehydratase

Pseudomonas aeruginosa

-

-

704330

Pterin carbinolamine dehydratase

-

-

-

-

Pterin-4 alpha-carbinolamine dehydratase

-

-

-

-

Pterin-4-alpha-carbinolamine dehydratase

-

-

-

-

Pterin-4a-carbinolamine dehydratase

7 entries

Pterin-4a-carbinolamine dehydratase (Aquifex aeolicus gene phhB)

-

-

-

-

Pterin-4a-carbinolamine dehydratase/dimerization cofactor of HNF1

-

-

-

-

Pterin-4alpha-carbinolamine dehydratase

3 entries

Pterin-4alpha-carbinolamine dehydratase (PCD)/dimerization cofactor for the transcription factor HBF-1alpha

-

-

-

-

XDCoH

-

-

-

-

additional information

2 entries

4a-Hydroxytetrahydrobiopterin dehydratase

-

-

-

-

4a-Hydroxytetrahydrobiopterin dehydratase

Homo sapiens

Q9H0N5

-

690623

DCoHalpha

Homo sapiens

-

-

681944

DCoHalpha

Homo sapiens

Q9H0N5

-

690623

PCD

-

-

-

-

PCD

Bombyx mori

-

-

742313

PCD

Homo sapiens

-

-

704967

PCD

Physcomitrium patens

-

-

716517

PCD

Pinus taeda

-

-

716517

PCD

Pseudomonas syringae

Q48G05

-

726660

PCD

Rattus norvegicus

-

-

649761, 714176

PCD

Toxoplasma gondii

Q2Q449

-

694063

PCD

Zea mays

B6TSX9

-

748945

PCD/DCoH

-

-

-

-

PCD/DCoH

Rattus norvegicus

-

-

649761

Pterin-4a-carbinolamine dehydratase

-

-

-

-

Pterin-4a-carbinolamine dehydratase

Bombyx mori

-

-

742313

Pterin-4a-carbinolamine dehydratase

Physcomitrium patens

-

-

716517

Pterin-4a-carbinolamine dehydratase

Pinus taeda

-

-

716517

Pterin-4a-carbinolamine dehydratase

Rattus norvegicus

-

-

649761, 714176

Pterin-4a-carbinolamine dehydratase

Toxoplasma gondii

Q2Q449

-

694063

Pterin-4a-carbinolamine dehydratase

Zea mays

B6TSX9

-

748945

Pterin-4alpha-carbinolamine dehydratase

-

-

-

-

Pterin-4alpha-carbinolamine dehydratase

Homo sapiens

-

-

704967

Pterin-4alpha-carbinolamine dehydratase

Pseudomonas syringae

Q48G05

-

726660

additional information

Rattus norvegicus

-

the enzyme has identical amino acid sequence to DCoH, the dimerization cofactor of the transcription regulator, HNF-1alpha

5938

additional information

Rattus norvegicus

-

the enzyme is identical with the dimerization cofactor DCoH, a cofactor for the hepatocyte nuclear factor 1alpha, HNF1alpha, which is essential for expression of phenylalanine hydroxylase PAH EC 1.14.16.1

649761