4.2.1.79: 2-methylcitrate dehydratase
This is an abbreviated version!
For detailed information about 2-methylcitrate dehydratase, go to the full flat file.
Word Map on EC 4.2.1.79
-
4.2.1.79
-
propionate
-
propionyl-coa
-
enterica
-
isocitrate
-
tuberculosis
-
methylisocitrate
-
oneidensis
-
cis-aconitate
-
prpbcde
-
odd-chain
-
shewanella
-
glyoxylate
-
prpf
-
beta-oxidation
-
serovar
-
smegmatis
-
propionyl
- 4.2.1.79
- propionate
- propionyl-coa
- enterica
- isocitrate
- tuberculosis
- methylisocitrate
- oneidensis
- cis-aconitate
-
prpbcde
-
odd-chain
-
shewanella
- glyoxylate
- prpf
-
beta-oxidation
-
serovar
- smegmatis
-
propionyl
Reaction
Synonyms
2-MC dehydratase, 2-methylcitrate dehydratase, 2-methylcitrate dehydratase 1, 2-Methylcitrate hydro-lyase, Dehydratase, 2-methylcitrate, methylcitrate dehydratase, mmgE, PrpD, SePrpD, STM0370
ECTree
4.2.1.79 2-methylcitrate dehydrataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.1.79 - 2-methylcitrate dehydratase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-Hydroxybutane-1,2,3-tricarboxylate
?
-
methylcitric acid cycle, propionyl-CoA oxidation
-
-
?
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate
(E)-but-2-ene-1,2,3-tricarboxylate + H2O
-
-
-
?
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate
(E)-but-2-ene-1,2,3-tricarboxylate + H2O
-
-
-
?
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate
(E)-but-2-ene-1,2,3-tricarboxylate + H2O
-
-
-
?
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate
(Z)-but-2-ene-1,2,3-tricarboxylate + H2O
-
-
-
?
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate
(Z)-but-2-ene-1,2,3-tricarboxylate + H2O
-
-
-
?
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate
(Z)-but-2-ene-1,2,3-tricarboxylate + H2O
-
-
-
?
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate
(Z)-but-2-ene-1,2,3-tricarboxylate + H2O
-
-
-
?
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate
(Z)-but-2-ene-1,2,3-tricarboxylate + H2O
Salmonella enterica subsp. enterica serovar Typhimurium LT2 / SGSC1412 / ATCC 700720
-
-
-
?
(2S,3S)-2-methylcitrate
cis-2-methylaconitate
the enzyme is involved in the methylcitric acid cycle
-
-
?
(2S,3S)-2-methylcitrate
cis-2-methylaconitate
the MmgE enzyme is not a stereospecific 2-methylcitrate dehydratase because it can dehydrate at least two of the four diastereomers of 2-methylcitrate to yield either (E)-2-methylaconitate or (Z)-2-methylaconitate
-
-
?
(2S,3S)-2-methylcitrate
cis-2-methylaconitate
the enzyme is involved in the methylcitric acid cycle
-
-
?
(2S,3S)-2-methylcitrate
cis-2-methylaconitate
the MmgE enzyme is not a stereospecific 2-methylcitrate dehydratase because it can dehydrate at least two of the four diastereomers of 2-methylcitrate to yield either (E)-2-methylaconitate or (Z)-2-methylaconitate
-
-
?
(2S,3S)-2-methylcitrate
cis-2-methylaconitate
the enzyme is involved in the methylcitric acid cycle
-
-
?
(2S,3S)-2-methylcitrate
cis-2-methylaconitate
the MmgE enzyme is not a stereospecific 2-methylcitrate dehydratase because it can dehydrate at least two of the four diastereomers of 2-methylcitrate to yield either (E)-2-methylaconitate or (Z)-2-methylaconitate
-
-
?
(2S,3S)-2-methylcitrate
cis-2-methylaconitate
the enzyme is involved in the methylcitric acid cycle
-
-
?
(2S,3S)-2-methylcitrate
cis-2-methylaconitate
the MmgE enzyme is not a stereospecific 2-methylcitrate dehydratase because it can dehydrate at least two of the four diastereomers of 2-methylcitrate to yield either (E)-2-methylaconitate or (Z)-2-methylaconitate
-
-
?
(2S,3S)-hydroxybutane-1,2,3-tricarboxylate
(Z)-but-2-ene-1,2,3-tricarboxylate + H2O
i.e. 2-methylcitrate, highly specific for, stereospecific for (2S,3S)-methylcitrate, the reverse reaction is an unusual syn-elimination
i.e. 2-methyl-cis-aconitate
?
(2S,3S)-hydroxybutane-1,2,3-tricarboxylate
(Z)-but-2-ene-1,2,3-tricarboxylate + H2O
enzyme performs the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate together with aconitase, both enzymes are essential, overview
-
r
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
2-Hydroxybutane-1,2,3-tricarboxylate
-
r
r, i.e. 2-methylcitrate
?
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
2-Hydroxybutane-1,2,3-tricarboxylate
-
i.e. 2-methyl-cis-aconitate
r, i.e. 2-methylcitrate
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
i.e. 2-methylcitrate, best substrate
i.e. 2-methyl-cis-aconitate
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
metabolic function
-
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
-
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
i.e. 2-methylcitrate
i.e. 2-methyl-cis-aconitate
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
i.e. 2-methylcitrate
i.e. 2-methyl-cis-aconitate
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
-
-
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
i.e. 2-methylcitrate, best substrate
i.e. 2-methyl-cis-aconitate
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
-
-
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
i.e. 2-methylcitrate, best substrate
i.e. 2-methyl-cis-aconitate
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
r
r
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
i.e. 2-methylcitrate
-
-
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
i.e. 2-methylcitrate
-
?
2-Hydroxybutane-1,2,3-tricarboxylate
(Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
i.e. 2-methylcitrate
r
?
cis-aconitate
?
5fold lower activity than with 2-methylcitrate
-
?
additional information
?
-
the MmgE enzyme is not a stereospecific 2-methylcitrate dehydratase because it can dehydrate at least two of the four diastereomers of 2-methylcitrate to yield either (E)-2-methylaconitate or (Z)-2-methylaconitate, but the physiological pathways proceed via (Z)-2-methylaconitate, which serves as the substrate for the citB enzyme in the synthesis of 2-methylisocitrate
-
-
?
additional information
?
-
the MmgE enzyme is not a stereospecific 2-methylcitrate dehydratase because it can dehydrate at least two of the four diastereomers of 2-methylcitrate to yield either (E)-2-methylaconitate or (Z)-2-methylaconitate, but the physiological pathways proceed via (Z)-2-methylaconitate, which serves as the substrate for the citB enzyme in the synthesis of 2-methylisocitrate
-
-
?
additional information
?
-
(2R,3S)-isocitrate and citrate are poor substrates, no activity with trans-aconitate, threo-2-methylisocitrate, erythro-2-methylisocitrate, (S)-malate and (R)-malate
-
?
additional information
?
-
-
(2R,3S)-isocitrate and citrate are poor substrates, no activity with trans-aconitate, threo-2-methylisocitrate, erythro-2-methylisocitrate, (S)-malate and (R)-malate
-
?
additional information
?
-
-
substrate specificity, no activity with cis-aconitate and related substances containing double bonds, overview
-
?
additional information
?
-
the PrpD enzyme from Escherichia coli is not a stereospecific 2-methylcitrate dehydratase because it can dehydrate at least two of the four diastereomers of 2-methylcitrate to yield either (E)-2-methylaconitate or (Z)-2-methylaconitate, but the physiological pathways proceed via (Z)-2-methylaconitate, which serves as the substrate for the citB enzyme in the synthesis of 2-methylisocitrate
-
-
?
additional information
?
-
-
enzyme of the methylcitrate cycle
-
-
?
additional information
?
-
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
-
enzyme of the methylcitrate cycle
-
-
?
additional information
?
-
enzyme does not catalyze the hydration of 2-methyl-cis-aconitate to 2-methylisocitrate, isocitrate is no substrate
-
?
additional information
?
-
-
enzyme does not catalyze the hydration of 2-methyl-cis-aconitate to 2-methylisocitrate, isocitrate is no substrate
-
?
additional information
?
-
the enzyme and the aconitase perform the 2-methylcitric acid cycle, overview
-
?
additional information
?
-
-
the enzyme and the aconitase perform the 2-methylcitric acid cycle, overview
-
?
additional information
?
-
-
PrpD does not catabolize 2-methylcitrate which is produced by the Krebs cycle enzyme citrate synthase GltA
-
-
?
additional information
?
-
-
PrpD does not catabolize 2-methylcitrate which is produced by the Krebs cycle enzyme citrate synthase GltA
-
-
?
additional information
?
-
-
2-methylisocitrate and isocitrate are no substrates for AcnD
-
?
additional information
?
-
-
2-methylisocitrate and isocitrate are no substrates for AcnD
-
?
additional information
?
-
-
not: citrate, threo-DL-isocitrate, threo-D-2-methylisocitrate, DL-homocitrate, DL-citramalate
-
-
?
