4.2.1.75: uroporphyrinogen-III synthase

This is an abbreviated version!
For detailed information about uroporphyrinogen-III synthase, go to the full flat file.

Reaction

Synonyms

CobA/HemD, Hydroxymethylbilane hydrolyase [cyclizing], hydroxymethylbilane hydrolyase, cyclizing, Isomerase, uroporphyrinogen, Porphobilinogenase, Synthase, uroporphyrinogen III co-, U3S, URO synthase, uro'gen III synthase, URO-synthase, UROIIIS, Uroporphyrinogen III co-synthase, Uroporphyrinogen III cosynthase, Uroporphyrinogen III synthase, Uroporphyrinogen isomerase, Uroporphyrinogen-III cosynthase, Uroporphyrinogen-III cosynthetase, uroporphyrinogen-III-synthase, UROS

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.75 uroporphyrinogen-III synthase

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Results	in table
4	Activating Compound
21465	AA Sequence
1	CAS Registry Number
20	Cloned(Commentary)
3	Crystallization (Commentary)
319	Disease/ Diagnostics
3	Expression
14	General Information
8	General Stability
38	Inhibitors
4	kcat/KM [mM/s]
14	KM Value [mM]
4	Localization
13	Metals/Ions
26	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
51	Organism
3	Oxidation Stability
8	Pathway
14	PDB ID
16	pH Optimum
4	pH Range
2	Posttranslational Modification
118	Protein Variants
20	Purification (Commentary)
8	Reaction
3	Reaction Type
50	Reference
1	Renatured (Commentary)
22	Source Tissue
11	Specific Activity [micromol/min/mg]
6	Storage Stability
56	Substrates and Products (Substrate)
17	Subunits
65	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
18	Temperature Stability [°C]
8	Turnover Number [1/s]

pH Range

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pH Range on EC 4.2.1.75 - uroporphyrinogen-III synthase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

6 - 9.5

Homo sapiens

-

-

5876

6.5 - 8.5

Mus musculus

-

at pH 6.5: 10% of optimum activity, at pH 8.5: 30% of optimum activity

5881

7 - 9

Escherichia coli

-

at pH 7.0: 60% of optimum activity, at pH 9.0: 60% of optimum activity

5888

7.5 - 9

Rattus norvegicus

-

pH 7.5: about 60% of maximal activity, pH 9.0: about 70% of maximal activity

682705